Interleukin-2 signals converge in a lymphoid–dendritic cell pathway that promotes anticancer immunity

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

(2020) Meenu Sharma et al.   Nature Communications

CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes

(2019) Moritz Rapp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

(2019) Mikhail Binnewies et al.   CELL

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications

(2019) Warren J. Leonard et al.   IMMUNITY

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

(2019) Charles-Antoine Dutertre et al.   IMMUNITY

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification

(2019) Vivek Durai et al.   NATURE IMMUNOLOGY

An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development

(2019) Prachi Bagadia et al.   NATURE IMMUNOLOGY

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

The role of cytokines in T-cell memory in health and disease

(2018) Miro E. Raeber et al.   IMMUNOLOGICAL REVIEWS

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

NKTR-214 (CD122-biased agonist) plus nivolumab in patients with advanced solid tumors: Preliminary phase 1/2 results of PIVOT.

(2018) Adi Diab et al.   JOURNAL OF CLINICAL ONCOLOGY

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells

(2017) Alejandro V. Villarino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy

(2017) Daniel Zingg et al.   Cell Reports

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Innate lymphoid cell function in the context of adaptive immunity

(2016) Jennifer K Bando et al.   NATURE IMMUNOLOGY

Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2

(2016) N. Arenas-Ramirez et al.   Science Translational Medicine

Deciphering the Innate Lymphoid Cell Transcriptional Program

(2016) Cyril Seillet et al.   Cell Reports

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Defining dendritic cells

(2015) Barbara U Schraml et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-2: Biology, Design and Application

(2015) Natalia Arenas-Ramirez et al.   TRENDS IN IMMUNOLOGY

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

(2015) A. R. Sanchez-Paulete et al.   Cancer Discovery

Vaccines Combined with Immune Checkpoint Antibodies Promote Cytotoxic T-cell Activity and Tumor Eradication

(2015) O. A. Ali et al.   Cancer Immunology Research

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors

(2014) Alan D. Guerrero et al.   IMMUNOLOGY

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

(2013) Rodney A. Rosalia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Increased expression of CD25, CD83, and CD86, and secretion of IL-12, IL-23, and IL-10 by human dendritic cells incubated in the presence of Toll-like receptor 2 ligands and Giardia duodenalis

(2013) Janine Obendorf et al.   Parasites & Vectors

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy

(2011) Simone C Wuest et al.   NATURE MEDICINE

Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells

(2011) A. W. Lau-Kilby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor   subunit CD25

(2010) S. Letourneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

(2010) C. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Dendritic cell homeostasis

(2009) M. Merad et al.   BLOOD

CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1

(2008) Caroline Pilon et al.   MOLECULAR IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY