Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break

Checkpoint Responses to DNA Double-Strand Breaks

(2020) David P. Waterman et al.   Annual Review of Biochemistry

Long-range enhancer–promoter contacts in gene expression control

(2019) Stefan Schoenfelder et al.   NATURE REVIEWS GENETICS

Structural Basis of an Asymmetric Condensin ATPase Cycle

(2019) Markus Hassler et al.   MOLECULAR CELL

Mec1ATR Autophosphorylation and Ddc2ATRIP Phosphorylation Regulates DNA Damage Checkpoint Signaling

(2019) Gonen Memisoglu et al.   Cell Reports

Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

(2019) Madhusudhan Srinivasan et al.   eLife

DNA loop extrusion by human cohesin

(2019) Iain F. Davidson et al.   SCIENCE

Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

(2017) Ishan Deshpande et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP

(2017) Xuejuan Wang et al.   SCIENCE

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

First-Passage Processes in the Genome

(2016) Yaojun Zhang et al.   Annual Review of Biophysics

Consider the workhorse: Nonhomologous end-joining in budding yeast

(2016) Charlene H. Emerson et al.   Biochemistry and Cell Biology

Chromosome-refolding model of mating-type switching in yeast

(2016) Barış Avşaroğlu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the intact ATM/Tel1 kinase

(2016) Xuejuan Wang et al.   Nature Communications

Long-Range Chromatin Interactions

(2015) Job Dekker et al.   Cold Spring Harbor Perspectives in Biology

Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity

(2015) Elisa Gobbini et al.   PLoS Genetics

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

(2015) Matteo Ferrari et al.   PLoS Genetics

Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism

(2014) Amitava Bandhu et al.   PLoS Genetics

Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends

(2013) Michela Clerici et al.   EMBO JOURNAL

Monitoring Homology Search during DNA Double-Strand Break Repair In Vivo

(2013) Jörg Renkawitz et al.   MOLECULAR CELL

Double strand break repair functions of histone H2AX

(2013) Ralph Scully et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break

(2013) Cheng-Sheng Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

Mating-Type Genes and MAT Switching in Saccharomyces cerevisiae

(2012) J. E. Haber   GENETICS

The Saccharomyces cerevisiae Chromatin Remodeler Fun30 Regulates DNA End Resection and Checkpoint Deactivation

(2012) V. V. Eapen et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Budding Yeast Mating-Type Switching Donor Preference by the FHA Domain of Fkh1

(2012) Jin Li et al.   PLoS Genetics

The cellular response to DNA damage: A focus on MDC1 and its interacting proteins

(2011) Gideon Coster et al.   Nucleus

Mad2 Prolongs DNA Damage Checkpoint Arrest Caused by a Double-Strand Break via a Centromere-Dependent Mechanism

(2010) Farokh Dotiwala et al.   CURRENT BIOLOGY

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA end resection: Many nucleases make light work

(2009) Eleni P. Mimitou et al.   DNA REPAIR

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

Crosstalk between histone modifications during the DNA damage response

(2009) Haico van Attikum et al.   TRENDS IN CELL BIOLOGY

Mappingin VivoChromatin Interactions in Yeast Suggests an Extended Chromatin Fiber with Regional Variation in Compaction

(2008) Job Dekker   JOURNAL OF BIOLOGICAL CHEMISTRY