Consider the workhorse: Nonhomologous end-joining in budding yeast

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining

(2015) Hui Yang et al.   DNA REPAIR

TDP1 promotes assembly of non-homologous end joining protein complexes on DNA

(2015) Jinho Heo et al.   DNA REPAIR

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease

(2015) Jana Prochazkova et al.   IMMUNOLOGY

Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection

(2015) Danielle S. Krasner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Error-Prone Repair of DNA Double-Strand Breaks

(2015) Kasey Rodgers et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining

(2015) Matthew Jessulat et al.   MOLECULAR AND CELLULAR BIOLOGY

Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae

(2015) A. Galli et al.   MUTAGENESIS

The Ku heterodimer: Function in DNA repair and beyond

(2015) Victoria L. Fell et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

(2015) Andrea J Hartlerode et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining inSaccharomyces cerevisiae

(2015) Damon Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mus81 and converging forks limit the mutagenicity of replication fork breakage

(2015) R. Mayle et al.   SCIENCE

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

(2015) Andrea J Hartlerode et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding

(2014) Kishore K. Chiruvella et al.   DNA REPAIR

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

DNA Dynamics during Early Double-Strand Break Processing Revealed by Non-Intrusive Imaging of Living Cells

(2014) Hicham Saad et al.   PLoS Genetics

A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae

(2013) Jennifer Summers McKinney et al.   BMC GENOMICS

An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation

(2013) Lisa Postow et al.   CELL CYCLE

DNA strand break repair and neurodegeneration

(2013) Stuart L. Rulten et al.   DNA REPAIR

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

(2013) Elisa Gobbini et al.   DNA REPAIR

The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining

(2013) Brandi L. Mahaney et al.   DNA REPAIR

Processing of DNA Double-stranded Breaks and Intermediates of Recombination and Repair bySaccharomyces cerevisiaeMre11 and Its Stimulation by Rad50, Xrs2, and Sae2 Proteins

(2013) Indrajeet Ghodke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

DNA repair choice defines a common pathway for recruitment of chromatin regulators

(2013) Gwendolyn Bennett et al.   Nature Communications

The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks

(2013) Alessia Balestrini et al.   Cell Reports

Yeast Pol4 Promotes Tel1-Regulated Chromosomal Translocations

(2013) Jose F. Ruiz et al.   PLoS Genetics

Saccharomyces cerevisiae DNA Ligase IV Supports Imprecise End Joining Independently of Its Catalytic Activity

(2013) Kishore K. Chiruvella et al.   PLoS Genetics

Mutations Arising During Repair of Chromosome Breaks

(2012) Anna Malkova et al.   Annual Review of Genetics

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

(2012) Brandi L. Mahaney et al.   Biochemistry and Cell Biology

Mating-Type Genes and MAT Switching in Saccharomyces cerevisiae

(2012) J. E. Haber   GENETICS

Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

(2012) Ketki Karanam et al.   MOLECULAR CELL

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

(2012) Xuefeng Chen et al.   NATURE

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

(2012) Lin Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Electron microscopy visualization of DNA–protein complexes formed by Ku and DNA ligase IV

(2011) Patricia Grob et al.   DNA REPAIR

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage

(2011) S. S. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

(2011) Marcel Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ku Must Load Directly onto the Chromosome End in Order to Mediate Its Telomeric Functions

(2011) Christopher R. Lopez et al.   PLoS Genetics

DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier

(2010) Olivier Fritsch et al.   DNA REPAIR

Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae

(2010) James W. Westmoreland et al.   DNA REPAIR

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

Yeast Nej1 Is a Key Participant in the Initial End Binding and Final Ligation Steps of Nonhomologous End Joining

(2010) Xi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

End-processing during non-homologous end-joining: a role for exonuclease 1

(2010) K. Bahmed et al.   NUCLEIC ACIDS RESEARCH

Yeast Tdp1 regulates the fidelity of nonhomologous end joining

(2010) K. Bahmed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

Accurate repair of non-cohesive, double strand breaks in Saccharomyces cerevisiae: enhancement by homology-assisted end-joining

(2010) Mario Moscariello et al.   YEAST

Methylated H3K4, a Transcription-Associated Histone Modification, Is Involved in the DNA Damage Response Pathway

(2010) David Faucher et al.   PLoS Genetics

Ku86 represses lethal telomere deletion events in human somatic cells

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionizing Radiation Induces Microhomology-Mediated End Joiningin transin Yeast and Mammalian Cells

(2009) Zorica Scuric et al.   RADIATION RESEARCH

Eukaryotic DNA Ligases: Structural and Functional Insights

(2008) Tom Ellenberger et al.   Annual Review of Biochemistry

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Pol3 is involved in nonhomologous end-joining in Saccharomyces cerevisiae

(2008) Cecilia Y. Chan et al.   DNA REPAIR

Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae

(2008) Brian M. Wasko et al.   DNA REPAIR

The Yku70–Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

(2008) Michela Clerici et al.   EMBO REPORTS

Multiple pathways inhibit NHEJ at telomeres

(2008) S. Marcand et al.   GENES & DEVELOPMENT

Forkhead-Associated Domain of Yeast Xrs2, a Homolog of Human Nbs1, Promotes Nonhomologous End Joining Through Interaction With a Ligase IV Partner Protein, Lif1

(2008) K. Matsuzaki et al.   GENETICS

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 Complex to a Double-Strand Break Requires Interactions With Yku80 and the Xrs2 FHA Domain

(2008) P. L. Palmbos et al.   GENETICS

Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae

(2008) D. Wu et al.   GENETICS

Ku80 removal from DNA through double strand break–induced ubiquitylation

(2008) Lisa Postow et al.   JOURNAL OF CELL BIOLOGY

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

ATP-dependent chromatin remodeling shapes the DNA replication landscape

(2008) Jack A Vincent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proofreading Activity of DNA Polymerase Pol2 Mediates 3′-End Processing during Nonhomologous End Joining in Yeast

(2008) Shun-Fu Tseng et al.   PLoS Genetics

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics

Evidence that base stacking potential in annealed 3′ overhangs determines polymerase utilization in yeast nonhomologous end joining

(2007) James M. Daley et al.   DNA REPAIR