Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

The Chemistry and Biology of Oligonucleotide Conjugates

(2012) R. L. Juliano et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nucleic Acid Delivery: The Missing Pieces of the Puzzle?

(2012) Juliane Nguyen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Development and validation of competition binding assays for affinity to the extracellular matrix receptors, αvβ3 and αIIbβ3 integrin

(2012) Alexander M. Szabo et al.   ANALYTICAL BIOCHEMISTRY

Unraveling the influence of endothelial cell density on VEGF-A signaling

(2012) L. Napione et al.   BLOOD

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

Drug targeting to the diseased liver

(2012) Klaas Poelstra et al.   JOURNAL OF CONTROLLED RELEASE

Transport to Late Endosomes Is Required for Efficient Reovirus Infection

(2012) Bernardo A. Mainou et al.   JOURNAL OF VIROLOGY

Multimodality Imaging In Vivo for Preclinical Assessment of Tumor-Targeted Doxorubicin Nanoparticles

(2012) Jae Youn Hwang et al.   PLoS One

P2Y12 inhibitors in acute coronary syndromes: How do we choose the best drug for our patients?

(2012) Erik L. Grove et al.   THROMBOSIS AND HAEMOSTASIS

Dynamics of receptor trafficking in tumorigenicity

(2012) Christine A. Parachoniak et al.   TRENDS IN CELL BIOLOGY

Integrin Targeted Delivery of Gene Therapeutics

(2012) Rudy L Juliano et al.   Theranostics

Integrin Targeted Therapeutics

(2012) Melissa Millard et al.   Theranostics

Why Integrin as a Primary Target for Imaging and Therapy

(2012) Gang Niu et al.   Theranostics

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

In search of the Holy Grail: Folate-targeted nanoparticles for cancer therapy

(2011) Alfonso Garcia-Bennett et al.   BIOCHEMICAL PHARMACOLOGY

Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA

(2011) Md. Rowshon Alam et al.   BIOCONJUGATE CHEMISTRY

Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides

(2011) Rudolph L. Juliano et al.   BIOCONJUGATE CHEMISTRY

Mechanisms of integrin activation and trafficking

(2011) Coert Margadant et al.   CURRENT OPINION IN CELL BIOLOGY

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration

(2011) Anja Mai et al.   JOURNAL OF CELL BIOLOGY

Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration

(2011) Zhizhan Gu et al.   JOURNAL OF CELL BIOLOGY

Unconventional internalization mechanisms underlying functional delivery of antisense oligonucleotides via cationic lipoplexes and polyplexes

(2011) Xin Ming et al.   JOURNAL OF CONTROLLED RELEASE

Molecular considerations for development of phage antibody libraries

(2011) Mohammad Reza Tohidkia et al.   JOURNAL OF DRUG TARGETING

Versatile Site-Specific Conjugation of Small Molecules to siRNA Using Click Chemistry

(2011) Takeshi Yamada et al.   JOURNAL OF ORGANIC CHEMISTRY

Targeting Axl and Mer Kinases in Cancer

(2011) A. Verma et al.   MOLECULAR CANCER THERAPEUTICS

Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA

(2011) Saurabh Singh et al.   PHARMACEUTICAL RESEARCH

Regulators of G-Protein Signaling and Their G  Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

(2011) A. J. Kimple et al.   PHARMACOLOGICAL REVIEWS

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of membrane traffic by integrin signaling

(2011) Sara A. Wickström et al.   TRENDS IN CELL BIOLOGY

Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow?

(2011) Nigel J. Pyne et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Entry at the trans-Face of the Golgi

(2011) S. R. Pfeffer   Cold Spring Harbor Perspectives in Biology

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

Drug targeting to the kidney: Advances in the active targeting of therapeutics to proximal tubular cells☆

(2010) M.E.M. Dolman et al.   ADVANCED DRUG DELIVERY REVIEWS

Role of urotensin II in health and disease

(2010) Bryan Ross et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation

(2010) Lin Zhu et al.   BIOCONJUGATE CHEMISTRY

Signal transduction by protease-activated receptors

(2010) Unice JK Soh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

(2010) Bahne Stechmann et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Hepatic stellate cell (vitamin A-storing cell) and its relative – past, present and future

(2010) Haruki Senoo et al.   CELL BIOLOGY INTERNATIONAL

Signaling endosomes: seeing is believing

(2010) Marta Miaczynska et al.   CURRENT OPINION IN CELL BIOLOGY

Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis

(2010) Mark T Howes et al.   CURRENT OPINION IN CELL BIOLOGY

Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes

(2010) Viola Hélène Lobert et al.   DEVELOPMENTAL CELL

Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics

(2010) Saghir Akhtar   Expert Opinion on Drug Metabolism & Toxicology

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

(2010) Lai Kuan Goh et al.   JOURNAL OF CELL BIOLOGY

Targeted Intracellular Delivery of Antisense Oligonucleotides via Conjugation with Small-Molecule Ligands

(2010) Osamu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

siRNA-Based Therapy Ameliorates Glomerulonephritis

(2010) H. Shimizu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor

(2010) Xin Ming et al.   NUCLEIC ACIDS RESEARCH

New links between vesicle coats and Rab-mediated vesicle targeting

(2010) Cortney G. Angers et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Signaling by internalized G-protein-coupled receptors

(2010) Davide Calebiro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Signal co-operation between integrins and other receptor systems

(2009) Charles H. Streuli et al.   BIOCHEMICAL JOURNAL

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Lipid-based nanotherapeutics for siRNA delivery

(2009) A. Schroeder et al.   JOURNAL OF INTERNAL MEDICINE

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

(2009) B. A. Molitoris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides

(2009) R. Juliano et al.   MOLECULAR PHARMACEUTICS

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

(2009) José B Sáenz et al.   Nature Chemical Biology

Integrins: masters and slaves of endocytic transport

(2009) Patrick T. Caswell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Biological Effect of an Antisense Oligonucleotide Depends on Its Route of Endocytosis and Trafficking

(2009) Md. Rowshon Alam et al.   OLIGONUCLEOTIDES

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus–host interaction

(2009) Stefan Kunz   VIROLOGY

Gene Silencing of Complement C5a Receptor Using siRNA for Preventing Ischemia/Reperfusion Injury

(2008) Xiufen Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor

(2008) Oleg Khorev et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Modelling cellular signalling systems

(2008) Padmini Rangamani et al.   Essays in Biochemistry

Publisher's Note

(2008)   EXPERIMENTAL CELL RESEARCH

Quantitative modeling perspectives on the ErbB system of cell regulatory processes

(2008) Matthew J. Lazzara et al.   EXPERIMENTAL CELL RESEARCH

Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation

(2008) Stéphanie Kermorgant et al.   JOURNAL OF CELL BIOLOGY

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

A Raft-derived, Pak1-regulated Entry Participates in α2β1 Integrin-dependent Sorting to Caveosomes

(2008) Mikko Karjalainen et al.   MOLECULAR BIOLOGY OF THE CELL

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

EGFR Antagonists in Cancer Treatment

(2008) Fortunato Ciardiello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis

(2008) Md Rowshon Alam et al.   NUCLEIC ACIDS RESEARCH

Systems Biology of Growth Factor-Induced Receptor Endocytosis

(2008) Yaara Zwang et al.   TRAFFIC

Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications

(2007) Aylin C. Hanyaloglu et al.   Annual Review of Pharmacology and Toxicology

Another ligand fishing for G protein-coupled receptor 14

(2007) Tsukasa Sugo et al.   PEPTIDES

The role of urotensin II in cardiovascular and renal physiology and diseases

(2006) Yi-Chun Zhu et al.   BRITISH JOURNAL OF PHARMACOLOGY