Review
Engineering, Multidisciplinary
Kottakkaran Sooppy Nisar, Muhammad Farman, Mahmoud Abdel-Aty, Jinde Cao
Summary: Biomathematics has emerged as a critical field of interdisciplinary research, particularly in the study of chronic diseases and infectious disease dynamics. In recent years, fractional calculus has been widely used to model the spread and treatment of various diseases, especially in the prevention and control of infectious diseases. By utilizing fractional operators, mathematical models can be improved to enhance our understanding of disease transmission and provide scientific basis for prevention and control.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Haroldo Ribeiro, Milena Oehlers, Ana Moreno-Monroy, Jurgen P. Kropp, Diego Rybski
Summary: The research found a connection between urban scaling and Zipf's law, where the scale returns of urban GDP are related to the distribution of cities within a country.
Article
Ecology
Robert Noble, Dominik Burri, Cecile Le Sueur, Jeanne Lemant, Yannick Viossat, Jakob Nikolas Kather, Niko Beerenwinkel
Summary: The mode of evolution in tumors is determined by the tumor's spatial structure, with cell dispersal and cell-cell interactions playing crucial roles in tumor evolution. Different spatial structures can lead to different tumor evolutionary modes, and model predictions align with empirical observations of cancers with varying architectures.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Environmental Sciences
Xingchen Zhao, Penghui Li, Shanjun Song, Huiyu Wang, Lining Zhao, Wansong Zong, Haiyan Zhang, Guangbo Qu, Ligang Hu, Zongwei Cai, Guibin Jiang
Summary: Bisphenol A and its analogs are transported by blood and bind estrogen receptors in target organs or cells, with moderate binding ability to human serum albumin. This interaction may influence their retention and toxicity in the bloodstream.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Bianca Striednig, Ulrike Lanner, Selina Niggli, Ana Katic, Simone Vormittag, Sabrina Brulisauer, Ramon Hochstrasser, Andres Kaech, Amanda Welin, Antje Flieger, Urs Ziegler, Alexander Schmidt, Hubert Hilbi, Nicolas Personnic
Summary: Legionella pneumophila, the causative agent of Legionnaires' disease, replicates in a distinct compartment within amoebae and macrophages. The pathogen switches between replicative, non-virulent and non-replicating, virulent/transmissive phases. Individual motile and virulent L. pneumophila cells emerge in the cluster of non-growing bacteria within the Legionella-containing vacuole at late stages of infection, with distinct proteomes and phenotypic heterogeneity. The emergence and spreading of a subpopulation of transmissive L. pneumophila at the LCV periphery at the end of an infection cycle are regulated by the Legionella quorum sensing system.
Article
Chemistry, Multidisciplinary
Vishal Kumar Jaiswal, Piotr Kabacinski, Barbara E. Nogueira de Faria, Marziogiuseppe Gentile, Ana Maria de Paula, Rocio Borrego-Varillas, Artur Nenov, Irene Conti, Giulio Cerullo, Marco Garavelli
Summary: By combining UV transient absorption spectroscopy with sub-30-fs temporal resolution and CASPT2/MM calculations, this study provides a complete description of the primary photoinduced processes in solvated tryptophan. The role of the solvent in the relaxation dynamics of tryptophan is clarified, and evidence of vibrational coherence is presented.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Kota Mitsumoto, Kyohei Takae
Summary: Metal-organic frameworks (MOFs) with high crystallinity and large surface area can undergo adsorption-desorption transition by changing their structure and elastic modulus. The role of elastic heterogeneity in this transition has been found to be asymmetric, leading to spatially heterogeneous domain formation between adsorbed and desorbed sites.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Astronomy & Astrophysics
Jing-Ze Ma, Bing Zhang
Summary: This study investigates the influence of different magnetic field geometries on relativistic shocks. The results show that the tangential magnetization has a greater impact on the jump conditions, regardless of the inclination angles or anisotropy of the magnetic field. The approximated analytical solution developed in this work is significant for numerical simulations and theoretical studies.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Physics, Multidisciplinary
Shilong Gao, Nunan Gao, Bixia Kan, Huiqi Wang
Summary: The paper demonstrates the influence of power-law heterogeneity of coupling coefficients on the output signal-to-noise ratio (SNR) of the central oscillator in coupled star-network. By creatively constructing a random variable to model the heterogeneity, it is found that the degree of heterogeneity of coupling coefficients can be measured by the entropy of random variables. Numerical simulations reveal the division of parameter space into different regions based on the output SNR, with discussions on the optimal SNR and power exponent in each region. The physical mechanism is explained based on stochastic resonance (SR) theory.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2021)
Article
Multidisciplinary Sciences
Olga Shishkov, Claudia Chen, Claire Allison Madonna, Kaushik Jayaram, Orit Peleg
Summary: To understand how swarms of bees maintain mechanical stability during colony reproduction, researchers conducted the first-ever 3D reconstructions of the bee positions in the swarm using x-ray computed tomography. They found that the mass of bees in a layer decreases with distance from the attachment surface, and discovered that a power law governs the weight distribution within swarms of different sizes. This power law ensures that each layer exerts the same proportion of its total strength, allowing bees to support lower weight than their maximum grip strength.
SCIENTIFIC REPORTS
(2022)
Article
Automation & Control Systems
Nuno C. Martins, Jair Certorio, Richard J. La
Summary: We propose a system theoretic approach to select and stabilize the endemic equilibrium of an SIRS epidemic model, with the decisions of a population determining the transmission rate. The population's agents revise their choices out of a set of strategies that impact the transmission rate. We develop a dynamic payoff mechanism that guarantees steering the epidemic variables to the endemic equilibrium with the smallest infectious fraction, subject to cost constraints.
Article
Multidisciplinary Sciences
Marta Pardo-Araujo, David Garcia-Garcia, David Alonso, Frederic Bartumeus
Summary: This article proposes a flexible modeling framework that examines the complex interaction between human behavior and infectious diseases in disease epidemics. By using random matrix theory, the study is able to calculate an epidemic threshold and understand the impact of human mobility and disease transmission on the early growth of epidemics, which is applicable in outbreak preparedness.
SCIENTIFIC REPORTS
(2023)
Article
Economics
M. Sylvina Porras-Arena, Angel L. Martin-Roman
Summary: Okun's law, an important parameter in empirical research and policy analysis, faces considerable heterogeneity due to dual interpretation and other factors such as labor market characteristics and methodological issues.
ECONOMIC MODELLING
(2023)
Article
Remote Sensing
Gang Xu, Wenwu Wang, Dandan Lu, Binbin Lu, Kun Qin, Limin Jiao
Summary: The study found that using a Geographically Weighted Regression model could better explain the impact of Wuhan outflows on COVID-19 cases in other cities, showing that not only cities around Wuhan, but also cities with close connections are more vulnerable.
GEO-SPATIAL INFORMATION SCIENCE
(2022)
Article
Mathematics, Applied
Xuzhen Zhu, Yuxin Wang, Ningbo Zhang, Hui Yang, Wei Wang
Summary: The spread of disease on complex networks has attracted extensive attention in various fields. This paper proposes an infection threshold model with neighbor resource support to account for the heterogeneity of node susceptibility. By utilizing improved heterogeneous mean-field theory and numerical simulations, the study finds that the mean and standard deviation of the infection threshold model significantly impact the phase transition and epidemic outbreak size. The results show that the system exhibits different types of transitions as the mean and standard deviation change.
Article
Multidisciplinary Sciences
Maria Romanova-Michaelides, Zena Hadjivasiliou, Daniel Aguilar-Hidalgo, Dimitris Basagiannis, Carole Seum, Marine Dubois, Frank Juelicher, Marcos Gonzalez-Gaitan
Summary: Research has found that scaling of the Dpp gradient in the Drosophila wing disc is achieved by increasing the contribution of internalized Dpp molecules to Dpp transport, regulated by the extracellular factor Pentagone. This evolutionary mechanism may act on endocytic trafficking to regulate the range and scaling of the gradient, allowing adaptation of shape and pattern to different sizes of organs in different species.
Article
Physics, Multidisciplinary
Jose A. Morin, Sina Wittmann, Sandeep Choubey, Adam Klosin, Stefan Golfier, Anthony A. Hyman, Frank Juelicher, Stephan W. Grill
Summary: This study investigates the nature of transcription factor condensates and demonstrates that transcription factors can undergo phase separation at high concentrations and form condensates on DNA at low concentrations. These condensates are shown to form on DNA as a type of surface condensation and are correlated with DNA sequence, thus explaining the size and position control of surface condensates.
Article
Physics, Multidisciplinary
Benjamin A. Dalton, David Oriola, Franziska Decker, Frank Juelicher, Jan Brugues
Summary: The study reveals the mechanism of spindle self-organization, showing that a gelation transition enables long-range microtubule transport and global coherent microtubule flows.
Article
Chemistry, Physical
Charlie Duclut, Joris Paijmans, Mandar M. Inamdar, Carl D. Modes, Frank Juelicher
Summary: In this paper, the authors used a vertex model to study T1 rearrangements in polygonal cellular networks and considered two different physical realizations of anisotropic active stresses. The results suggest that these realizations can be observed in vivo and lead to different patterns of relative orientation. The energetics of the dynamic tissue were also discussed, defining active T1 transitions that can perform mechanical work while consuming chemical energy.
EUROPEAN PHYSICAL JOURNAL E
(2022)
Article
Physics, Multidisciplinary
Tyler S. Harmon, Frank Julicher
Summary: In this study, we propose a reliable method for assembling protein complexes into the correct structure using an assembly line with a specific sequence of assembly steps. By utilizing droplet interfaces to position compartment boundaries, we demonstrate that an assembly line can be self-organized by active droplets. As a result, assembly steps can be spatially arranged to achieve a specific order of assembly and prevent incorrect assembly.
PHYSICAL REVIEW LETTERS
(2022)
Article
Multidisciplinary Sciences
Roman Renger, Jose A. Morin, Regis Lemaitre, Martine Ruer-Gruss, Frank Juelicher, Andreas Hermann, Stephan W. Grill
Summary: This study investigated the mechanism of how the FUS protein forms liquid-like assemblies by co-condensing with DNA molecules in vitro. It was found that the protein could adsorb onto DNA to generate a sticky FUS-DNA polymer, which then collapsed to form a liquid-like FUS-DNA co-condensate. The co-condensation mechanism mediated by protein adsorption on nucleic acids is suggested to be important for intracellular compartmentalization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Physics, Multidisciplinary
Jonathan Bauermann, Christoph A. Weber, Frank Juelicher
Summary: Chemically active droplets serve as simple models for cell-like systems that can grow and divide. Two scenarios of nonequilibrium driving are considered – boundary-driven and bulk-driven. The conservation of energy and matter, as well as the balance of entropy, are discussed. The research reveals that droplet division can generally occur in active droplet systems that combine phase separation and chemical reactions.
ANNALEN DER PHYSIK
(2022)
Article
Multidisciplinary Sciences
Victoria Tianjing Yan, Arjun Narayanan, Tina Wiegantr, Frank Juelicher, Stephan W. Grill
Summary: Activation of the contractile actomyosin cortex is key to development in C. elegans oocytes, and this activation is supported by the emergence of short-lived protein condensates rich in F-actin, N-WASP, and the ARP2/3 complex. These condensates form an active micro-emulsion and exhibit chemically driven growth dynamics, preventing coarsening of the micro-emulsion and ensuring reaction kinetics independent of condensate size.
Article
Physics, Multidisciplinary
Marie Pochitaloff, Martin Miranda, Mathieu Richard, Atitheb Chaiyasitdhi, Yasuharu Takagi, Wenxiang Cao, Enrique M. De la Cruz, James R. Sellers, Jean-Francois Joanny, Frank Juelicher, Laurent Blanchoin, Pascal Martin
Summary: The authors demonstrate that the wave-like motion of cilia can be reconstituted in vitro by self-assembling polymerizing actin filaments and myosin motors. The binding of myosin to actin depends on the shape of the actin bundle, providing a feedback mechanism for the coordination between motor activity and filament deformations.
Article
Cell Biology
Alicia Daeden, Alexander Mietke, Emmanuel Derivery, Carole Seum, Frank Juelicher, Marcos Gonzalez-Gaitan
Summary: This study reveals that unequal daughter-cell sizes resulting from asymmetric sensory organ precursor divisions in Drosophila are controlled by the relative amount of cortical branched Actin between the two cell poles. By manipulating the machinery for branched Actin dynamics, the researchers can engineer the cell shape and daughter-cell size with temporal precision at different stages of cytokinesis. The findings uncover the physical mechanism by which the sensory organ precursor mother cell controls relative daughter-cell size.
NATURE CELL BIOLOGY
(2023)
Article
Physics, Multidisciplinary
Keisuke Ishihara, Arghyadip Mukherjee, Elena Gromberg, Jan Brugues, Elly M. Tanaka, Frank Juelicher
Summary: Animal organs exhibit complex topologies involving cavities and tubular networks, which are governed by two distinct modes of topological transitions. These transitions can be regulated through a pharmacologically accessible pathway, enabling control over organ shape and topology.
Correction
Multidisciplinary Sciences
Victoria Tianjing Yan, Arjun Narayanan, Tina Wiegand, Frank Juelicher, Stephan W. Grill
Article
Engineering, Electrical & Electronic
Christian Hoyer, Lucas Wetzel, Dimitrios Prousalis, Jens Wagner, Frank Juelicher, Frank Ellinger
Summary: Synchronization is a challenging aspect of distributed systems, especially in globally operating data centers or distributed sensor arrays. Existing solutions based on hierarchical synchronization concepts have a single point of failure. This study explores the combination of hierarchical and mutual synchronization to achieve more resilient solutions.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2023)
Article
Physics, Fluids & Plasmas
Joel Mabillard, Christoph A. Weber, Frank Juelicher
Summary: Chemical events in active systems generate heat and lead to active fluctuations, keeping the system out of thermal equilibrium. This study shows that active fluctuations dominate thermal fluctuations on large length and timescales, but multiple crossovers exist at intermediate length and timescales, revealing the different characteristics of active and thermal fluctuations. The findings provide a framework to understand fluctuations in active systems and uncover the presence of local equilibrium at certain length and timescales.