Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2020) Yanyan Zhu et al.   PHARMACOLOGICAL RESEARCH

Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK−2) exposed to diabetic milieu

(2020) Jung Eun Nam et al.   LIFE SCIENCES

Astragaloside IV inhibits oxidized low‑density lipoprotein‑induced endothelial damage via upregulation of miR‑140‑3p

(2019) Weibin Qian et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Eriodictyol inhibits high glucose‐induced extracellular matrix accumulation, oxidative stress, and inflammation in human glomerular mesangial cells

(2019) Jin Bai et al.   PHYTOTHERAPY RESEARCH

Diabetic nephropathy: Is there a role for oxidative stress?

(2018) Manpreet K. Sagoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis

(2018) Qingqing Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

(2018) Xun Huang et al.   CELL

Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice

(2018) Xiaolei Wang et al.   Drug Design Development and Therapy

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit

(2018) Xiaolei Wang et al.   Drug Design Development and Therapy

NOD1 and NOD2 in inflammation, immunity and disease

(2018) Tapas Mukherjee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats

(2018) Yinghui Ju et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care

(2017) Junji Yodoi et al.   Nutrients

Mitochondrial Reactive Oxygen Species and Kidney Hypoxia in the Development of Diabetic Nephropathy

(2017) Tomas A. Schiffer et al.   Frontiers in Physiology

Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network

(2017) Xinhui Liu et al.   PLoS One

Oxidative stress markers in type 2 diabetes patients with diabetic nephropathy

(2016) Su-Tze Chou et al.   Clinical and Experimental Nephrology

Research review on the pharmacological effects of astragaloside IV

(2016) Lei Li et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

The NLRP3 inflammasome in kidney disease and autoimmunity

(2016) Holly L Hutton et al.   NEPHROLOGY

Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis

(2016) Shirong Zheng et al.   Journal of Diabetes Research

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

(2016) Hong Feng et al.   Journal of Diabetes Research

Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease

(2016) Alejandra Guillermina Miranda-Díaz et al.   Journal of Diabetes Research

Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic Nephropathy

(2016) Hengjiang Guo et al.   Frontiers in Pharmacology

The role of oxidative stress in streptozotocin-induced diabetic nephropathy in rats

(2016) Sheila Marques Fernandes et al.   Archives of Endocrinology Metabolism

Astragaloside IV ameliorates renal injury in db/db mice

(2016) Huili Sun et al.   Scientific Reports

Effects of Astragaloside IV on diabetic nephropathy in rats

(2015) W.-S. Lu et al.   GENETICS AND MOLECULAR RESEARCH

Updating the natural history of diabetic nephropathy

(2014) Giuseppe Pugliese   ACTA DIABETOLOGICA

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

(2014) Yifang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats

(2014) Jianguo Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression

(2013) Dingkun Gui et al.   CYTOKINE

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

NADPH Oxidases, Reactive Oxygen Species, and the Kidney: Friend and Foe

(2013) M. Sedeek et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy

(2013) Pengchao Du et al.   KIDNEY INTERNATIONAL

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

(2013) Shu-Chen Hung et al.   PLoS One

Astragaloside IV Attenuates Experimental Autoimmune Encephalomyelitis of Mice by Counteracting Oxidative Stress at Multiple Levels

(2013) Yixin He et al.   PLoS One

Pannexin: From discovery to bedside in 11±4 years?

(2012) Gerhard Dahl et al.   BRAIN RESEARCH

US Renal Data System 2011 Annual Data Report

(2011) Allan J. Collins et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes

(2011) Ling Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Temporal Trends in the Prevalence of Diabetic Kidney Disease in the United States

(2011) Ian H. de Boer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Astragaloside IV Improves Metabolic Syndrome and Endothelium Dysfunction in Fructose-Fed Rats

(2011) Ning Zhang et al.   MOLECULES

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

(2010) Nina Reiniger et al.   DIABETES

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

Advanced Glycation end Products, Oxidative Stress and Diabetic Nephropathy

(2010) Sho-ichi Yamagishi et al.   Oxidative Medicine and Cellular Longevity

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

(2010) Y. Chen et al.   Science Signaling

The oxidative stress status in diabetes mellitus and diabetic nephropathy

(2009) Hong-zhi Pan et al.   ACTA DIABETOLOGICA

Astragalosides Isolated from the Root of Astragalus Radix Inhibit the Formation of Advanced Glycation End Products

(2009) Keita Motomura et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease

(2009) Sho-ichi Yamagishi et al.   PHARMACOLOGICAL RESEARCH

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via α3β1 integrin upregulation and integrin-linked kinase inhibition

(2008) Jianguo Chen et al.   BIOCHEMICAL PHARMACOLOGY

Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications

(2008) Z. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy

(2008) Frank C. Brosius   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide

(2007) Peng Ai et al.   JOURNAL OF ETHNOPHARMACOLOGY