Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer

Structural analysis of VDR complex with ZK168281 antagonist

(2020) Anna Belorusova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Twenty years of Mediator complex structural studies

(2019) Alexis Verger et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

The mediator complex in genomic and non-genomic signaling in cancer

(2018) Hannah Weber et al.   STEROIDS

The nuclear receptor superfamily: A structural perspective

(2018) Emily R. Weikum et al.   PROTEIN SCIENCE

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Structural and Functional Impacts of ER Coactivator Sequential Recruitment

(2017) Ping Yi et al.   MOLECULAR CELL

Transcription regulation by the Mediator complex

(2017) Julie Soutourina   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA

(2017) Ian Mitchelle S. de Vera et al.   STRUCTURE

The Mediator Complex: At the Nexus of RNA Polymerase II Transcription

(2017) Célia Jeronimo et al.   TRENDS IN CELL BIOLOGY

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

(2017) Jie Zheng et al.   Nature Communications

Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

(2017) Ondrej Zenata et al.   Oncotarget

Integrated Workflow for Structural Proteomics Studies Based on Cross-Linking/Mass Spectrometry with an MS/MS Cleavable Cross-Linker

(2016) Christian Arlt et al.   ANALYTICAL CHEMISTRY

PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specificUcp1gene through interactions with Mediator subunit MED1

(2015) Satoshi Iida et al.   GENES & DEVELOPMENT

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

(2015) Matthew J. Harms et al.   GENES & DEVELOPMENT

Structure of a Biologically Active Estrogen Receptor-Coactivator Complex on DNA

(2015) Ping Yi et al.   MOLECULAR CELL

Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPAR -driven enhancers

(2014) S. E. Step et al.   GENES & DEVELOPMENT

Agonist Ligands Mediate the Transcriptional Response of Nuclear Receptor Heterodimers through Distinct Stoichiometric Assemblies with Coactivators

(2014) Mark Remec Pavlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Automated Assignment of MS/MS Cleavable Cross-Links in Protein 3D-Structure Analysis

(2014) Michael Götze et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation

(2014) C.-L. Hsieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distance restraints from crosslinking mass spectrometry: Mining a molecular dynamics simulation database to evaluate lysine-lysine distances

(2014) Eric D. Merkley et al.   PROTEIN SCIENCE

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

(2013) Fan Lai et al.   NATURE

Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes

(2012) Mark B. Meyer et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

Nuclear receptor coregulators: modulators of pathology and therapeutic targets

(2012) David M. Lonard et al.   Nature Reviews Endocrinology

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

(2012) J. Osz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping Unstructured Regions and Synergistic Folding in Intrinsically Disordered Proteins with Amide H/D Exchange Mass Spectrometry

(2011) Theodore R. Keppel et al.   BIOCHEMISTRY

The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

(2011) Matthew D Krasowski et al.   BMC BIOCHEMISTRY

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

(2011) Igor Orlov et al.   EMBO JOURNAL

Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

(2011) Liang Bai et al.   HEPATOLOGY

Regulation of Androgen Receptor-dependent Transcription by Coactivator MED1 Is Mediated through a Newly Discovered Noncanonical Binding Motif

(2011) Feng Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

(2011) Yuko Oda et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings

(2011) Natacha Rochel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

(2011) Jun Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mediator-dependent nuclear receptor function

(2011) Wei Chen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cleavable Cross-Linker for Protein Structure Analysis: Reliable Identification of Cross-Linking Products by Tandem MS

(2010) Mathias Q. Müller et al.   ANALYTICAL CHEMISTRY

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism

(2010) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of the Vitamin D Receptor−Coregulator Interaction†

(2009) Arnaud Teichert et al.   BIOCHEMISTRY

Dynamic Interactions and Cooperative Functions of PGC-1α and MED1 in TRα-Mediated Activation of the Brown-Fat-Specific UCP-1 Gene

(2009) Wei Chen et al.   MOLECULAR CELL

CCAR1, a Key Regulator of Mediator Complex Recruitment to Nuclear Receptor Transcription Complexes

(2008) Jeong Hoon Kim et al.   MOLECULAR CELL