Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

Construction of a GPR18 Receptor Model using Conformational Memories

(2013) Marianne G. Schmeisser et al.   BIOPHYSICAL JOURNAL

Antagonists for the Orphan G-Protein-Coupled Receptor GPR55 Based on a Coumarin Scaffold

(2013) Viktor Rempel et al.   JOURNAL OF MEDICINAL CHEMISTRY

8-Benzamidochromen-4-one-2-carboxylic Acids: Potent and Selective Agonists for the Orphan G Protein-Coupled Receptor GPR35

(2013) Mario Funke et al.   JOURNAL OF MEDICINAL CHEMISTRY

6-Bromo-8-(4-[3H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: A Powerful Tool for Studying Orphan G Protein-Coupled Receptor GPR35

(2013) Dominik Thimm et al.   JOURNAL OF MEDICINAL CHEMISTRY

GPR18 in microglia: implications for the CNS and endocannabinoid system signalling

(2012) D McHugh   BRITISH JOURNAL OF PHARMACOLOGY

7-Alkyl-3-benzylcoumarins: A Versatile Scaffold for the Development of Potent and Selective Cannabinoid Receptor Agonists and Antagonists

(2012) Viktor Rempel et al.   JOURNAL OF MEDICINAL CHEMISTRY

GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors

(2012) Pingwei Zhao et al.   LIFE SCIENCES

Functional Characterization and Analgesic Effects of Mixed Cannabinoid Receptor/T-Type Channel Ligands

(2012) Haitao You et al.   Molecular Pain

Off-Target Cannabinoid Effects Mediated by GPR55

(2012) Christopher M. Henstridge   PHARMACOLOGY

Cannabinoid receptors: nomenclature and pharmacological principles

(2012) Linda Console-Bram et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55

(2012) Viktor Rempel et al.   ACS Medicinal Chemistry Letters

Identification of the GPR55 Agonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands

(2011) Evangelia Kotsikorou et al.   BIOCHEMISTRY

So what do we call GPR18 now?

(2011) SPH Alexander   BRITISH JOURNAL OF PHARMACOLOGY

Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

(2011) Douglas McHugh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Homology modeling in tandem with 3D-QSAR analyses: A computational approach to depict the agonist binding site of the human CB2 receptor

(2011) Elena Cichero et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

(2011) Sharon Anavi-Goffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist

(2011) A. J. Brown et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

L-α-Lysophosphatidylinositol meets GPR55: a deadly relationship

(2011) Ruth A. Ross   TRENDS IN PHARMACOLOGICAL SCIENCES

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

(2010) Douglas McHugh et al.   BMC NEUROSCIENCE

GPR55 ligands promote receptor coupling to multiple signalling pathways

(2010) Christopher M Henstridge et al.   BRITISH JOURNAL OF PHARMACOLOGY

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

(2010) R Piñeiro et al.   ONCOGENE

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Pharmacological characterization of GPR55, a putative cannabinoid receptor

(2010) Haleli Sharir et al.   PHARMACOLOGY & THERAPEUTICS

Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target

(2010) Y. Qin et al.   Pigment Cell & Melanoma Research

Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists

(2009) Andrea Behrenswerth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways

(2009) Heather B Bradshaw et al.   BMC BIOCHEMISTRY

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands

(2009) Ankur Kapur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The therapeutic potential of novel cannabinoid receptors

(2009) Faith R. Kreitzer et al.   PHARMACOLOGY & THERAPEUTICS

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

(2009) L. S. Whyte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GPR55 ligand l-α-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

(2008) Christopher M. Henstridge et al.   FASEB JOURNAL

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY