Structural dissimilarity from self drives neoepitope escape from immune tolerance

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

(2020) Adil Doganay Duru et al.   PLoS Pathogens

Structure Based Prediction of Neoantigen Immunogenicity

(2019) Timothy P. Riley et al.   Frontiers in Immunology

Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade

(2019) Lee P. Richman et al.   Cell Systems

pMHC Structural Comparisons as a Pivotal Element to Detect and Validate T-Cell Targets for Vaccine Development and Immunotherapy—A New Methodological Proposal

(2019) Priscila Vianna et al.   Cells

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

(2018) Janos L. Tanyi et al.   Science Translational Medicine

Sensitive and frequent identification of high avidity neo-epitope specific CD8+ T cells in immunotherapy-naive ovarian cancer

(2018) Sara Bobisse et al.   Nature Communications

A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations

(2018) Jugmohit S. Toor et al.   Frontiers in Immunology

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability

(2018) Timothy P. Riley et al.   Nature Chemical Biology

Cancer Neoantigens

(2018) Ton N. Schumacher et al.   Annual Review of Immunology

Modeling Sequence-Dependent Peptide Fluctuations in Immunologic Recognition

(2017) Cory M. Ayres et al.   Journal of Chemical Information and Modeling

Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes

(2017) Nishant K. Singh et al.   JOURNAL OF IMMUNOLOGY

NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data

(2017) Vanessa Jurtz et al.   JOURNAL OF IMMUNOLOGY

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

(2017) Marta Łuksza et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

How an alloreactive T-cell receptor achieves peptide and MHC specificity

(2017) Yuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity

(2017) Michal Bassani-Sternberg et al.   PLoS Computational Biology

Identification and Characterization of Neoantigens As Well As Respective Immune Responses in Cancer Patients

(2017) Eva Bräunlein et al.   Frontiers in Immunology

The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design

(2017) Ward Fleri et al.   Frontiers in Immunology

An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes

(2017) Anne-Mette Bjerregaard et al.   Frontiers in Immunology

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

(2016) David K. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes

(2016) Lance M. Hellman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire

(2016) Sydney J. Blevins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

(2016) Michal Bassani-Sternberg et al.   Nature Communications

Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity

(2016) Cory M. Ayres et al.   Scientific Reports

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

Probing the active site tryptophan ofStaphylococcus aureusthioredoxin with an analog

(2015) Markus Englert et al.   NUCLEIC ACIDS RESEARCH

TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+T cell epitopes

(2015) Diego Chowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DockTope: a Web-based tool for automated pMHC-I modelling

(2015) Maurício Menegatti Rigo et al.   Scientific Reports

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity

(2014) Fei Duan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Properties of MHC Class I Presented Peptides That Enhance Immunogenicity

(2013) Jorg J. A. Calis et al.   PLoS Computational Biology

Role of T Cell Receptor Affinity in the Efficacy and Specificity of Adoptive T Cell Therapies

(2013) Jennifer D. Stone et al.   Frontiers in Immunology

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

(2012) A. G. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of T Cell Antigen Recognition Arising from Changes in Peptide and Major Histocompatibility Complex Protein Flexibility

(2011) Francis K. Insaidoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Smoothed Backbone-Dependent Rotamer Library for Proteins Derived from Adaptive Kernel Density Estimates and Regressions

(2011) Maxim V. Shapovalov et al.   STRUCTURE

Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

(2010) A. Theodossis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity

(2010) Yi Zhang et al.   PLoS Pathogens

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology