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Title
The Key Role of IP6K: A Novel Target for Anticancer Treatments?
Authors
Keywords
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Journal
MOLECULES
Volume 25, Issue 19, Pages 4401
Publisher
MDPI AG
Online
2020-09-25
DOI
10.3390/molecules25194401
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Note: Only part of the references are listed.- Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling
- (2020) Xingyao Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
- (2020) Sandip Mukherjee et al. MOLECULES
- Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling
- (2020) D. Eric Dollins et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
- (2019) Miranda S. Wilson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism
- (2019) Yann Desfougères et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
- (2018) Vasudha S. Nair et al. BIOSCIENCE REPORTS
- Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
- (2018) Subu Surendran Rajasekaran et al. CELLULAR SIGNALLING
- IP6K1 is essential for chromatoid body formation and temporal regulation ofTnp2andPrm2expression in mouse spermatids
- (2017) Aushaq Bashir Malla et al. JOURNAL OF CELL SCIENCE
- KO of 5-InsP7kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype
- (2017) Chunfang Gu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase
- (2017) Chenglai Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain
- (2017) Qingzhang Zhu et al. Molecular Metabolism
- Akt activation: A potential strategy to ameliorate insulin resistance
- (2017) Zhengyi Zhang et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
- (2016) M. Chanduri et al. BIOCHEMICAL JOURNAL
- AKT in cancer: new molecular insights and advances in drug development
- (2016) Prabhjot S. Mundi et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice
- (2016) Rathan S. Jadav et al. CELLULAR SIGNALLING
- Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement
- (2016) Simona Dinicola et al. EXPERIMENTAL CELL RESEARCH
- Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease
- (2016) Mariano Bizzarri et al. Expert Opinion on Drug Metabolism & Toxicology
- Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway
- (2016) TOMOYUKI KOGUCHI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells
- (2016) Wenxi Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis
- (2016) Qingzhang Zhu et al. JOURNAL OF CLINICAL INVESTIGATION
- Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe
- (2016) Boris Topolski et al. MOLECULAR AND CELLULAR BIOLOGY
- Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis
- (2016) Tae-Sun Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nudt3 is an mRNA decapping enzyme that modulates cell migration
- (2016) Ewa Grudzien-Nogalska et al. RNA
- Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- (2016) Mariano Bizzarri et al. International Journal of Endocrinology
- Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice
- (2016) Yusuke Moritoh et al. Scientific Reports
- TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
- (2016) Sarbani Ghoshal et al. Molecular Metabolism
- Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription inSaccharomyces cerevisiae
- (2015) Swarna Gowri Thota et al. BIOCHEMICAL JOURNAL
- The emerging roles of inositol pyrophosphates in eukaryotic cell physiology
- (2015) Swarna Gowri Thota et al. JOURNAL OF BIOSCIENCES
- Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity
- (2015) Dongdong Sun et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin
- (2015) C. Fu et al. JOURNAL OF NEUROSCIENCE
- Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation
- (2015) Eiichiro Nagata et al. MOLECULAR NEUROBIOLOGY
- Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1
- (2015) Feng Rao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine
- (2015) M. S. C. Wilson et al. Open Biology
- Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6degradation driven by the cellular ATP/ADP ratio
- (2014) Torsten Wundenberg et al. BIOCHEMICAL JOURNAL
- Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4–signalosome complex to regulate DNA repair and cell death
- (2014) Feng Rao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New tricks for an old fox: Impact of TGF on the DNA damage response and genomic stability
- (2014) M. H. Barcellos-Hoff et al. Science Signaling
- Insulin Receptor Signaling in Normal and Insulin-Resistant States
- (2014) J. Boucher et al. Cold Spring Harbor Perspectives in Biology
- Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
- (2014) Richard Mackenzie et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3for polyphosphoinositide-binding domains
- (2013) Nikhil A. Gokhale et al. BIOCHEMICAL JOURNAL
- Inositol pyrophosphates: between signalling and metabolism
- (2013) Miranda S. C. Wilson et al. BIOCHEMICAL JOURNAL
- Regulation of Inositol Metabolism Is Fine-tuned by Inositol Pyrophosphates inSaccharomyces cerevisiae
- (2013) Cunqi Ye et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate
- (2013) Y. Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) A. Burton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) Jeremy Worley et al. Cell Reports
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- (2012) Torsten Wundenberg et al. BIOLOGICAL CHEMISTRY
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- (2012) Rathan S. Jadav et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA
- (2012) M. A. Brehm et al. JOURNAL OF CELL SCIENCE
- Multiple modes of cytoplasmic dynein regulation
- (2012) Richard B. Vallee et al. NATURE CELL BIOLOGY
- Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers
- (2012) Mingxuan Wu et al. Chemical Science
- Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer
- (2011) E E Vincent et al. BRITISH JOURNAL OF CANCER
- Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase
- (2011) Seyun Kim et al. Cell Metabolism
- Inositol Hexakisphosphate Kinases Induce Cell Death in Huntington Disease
- (2011) Eiichiro Nagata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of an Evolutionarily Conserved Family of Inorganic Polyphosphate Endopolyphosphatases
- (2011) Annalisa Lonetti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling
- (2011) Amit Prasad et al. NATURE IMMUNOLOGY
- Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
- (2011) Z. Szijgyarto et al. SCIENCE
- Inositol Pyrophosphates as Mammalian Cell Signals
- (2011) A. Chakraborty et al. Science Signaling
- Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
- (2010) Julian Carretero et al. CANCER CELL
- Nuclear Janus-Activated Kinase 2/Nuclear Factor 1-C2 Suppresses Tumorigenesis and Epithelial-to-Mesenchymal Transition by Repressing Forkhead Box F1
- (2010) J. Nilsson et al. CANCER RESEARCH
- Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain
- (2010) Anutosh Chakraborty et al. CELL
- Inositol phosphate synthesis and the nuclear processes they affect
- (2010) Jessica P Monserrate et al. CURRENT OPINION IN CELL BIOLOGY
- Involvement of LKB1 in epithelial–mesenchymal transition (EMT) of human lung cancer cells
- (2010) Badal C. Roy et al. LUNG CANCER
- Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
- (2010) Y. C. Long et al. MOLECULAR AND CELLULAR BIOLOGY
- The Rpd3L HDAC complex is essential for the heat stress response in yeast
- (2010) Clàudia Ruiz-Roig et al. MOLECULAR MICROBIOLOGY
- p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
- (2010) M. A. Koldobskiy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway
- (2010) B. Sarmah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inositol pyrophosphates modulate hydrogen peroxide signalling
- (2009) Sara Maria Nancy Onnebo et al. BIOCHEMICAL JOURNAL
- EMT, the cytoskeleton, and cancer cell invasion
- (2009) Mahmut Yilmaz et al. CANCER AND METASTASIS REVIEWS
- Inositol pyrophosphates: structure, enzymology and function
- (2009) Christopher John Barker et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Characterization of a Selective Inhibitor of Inositol Hexakisphosphate Kinases
- (2009) Usha Padmanabhan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis
- (2009) Z. Xie et al. MOLECULAR AND CELLULAR BIOLOGY
- Growth-limiting Intracellular Metabolites in Yeast Growing under Diverse Nutrient Limitations
- (2009) Viktor M. Boer et al. MOLECULAR BIOLOGY OF THE CELL
- Diphosphoinositol Polyphosphates: Metabolic Messengers?
- (2009) S. B. Shears MOLECULAR PHARMACOLOGY
- Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma
- (2009) B H Morrison et al. ONCOGENE
- Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes
- (2009) V. Soppina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release
- (2009) Cristina Azevedo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice
- (2008) Yasuhiro Izumiya et al. Cell Metabolism
- Inositol Hexakisphosphate Kinase Products Contain Diphosphate and Triphosphate Groups
- (2008) Petra Draškovič et al. CHEMISTRY & BIOLOGY
- Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases
- (2008) Hongying Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein Kinase Cζ-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells
- (2008) Ping Song et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular Energetic Status Supervises the Synthesis of Bis-Diphosphoinositol Tetrakisphosphate Independently of AMP-Activated Protein Kinase
- (2008) K. Choi et al. MOLECULAR PHARMACOLOGY
- Inositol derivatives: evolution and functions
- (2008) Robert H. Michell NATURE REVIEWS MOLECULAR CELL BIOLOGY
- HSP90 regulates cell survival via inositol hexakisphosphate kinase-2
- (2008) A. Chakraborty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis
- (2008) R. Bhandari et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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