Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression

Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder

(2020) Sophia Attwells et al.   BIOLOGICAL PSYCHIATRY

Immunological and behavioral responses to in vivo lipopolysaccharide administration in young and healthy obese and normal-weight humans

(2020) Julie Lasselin et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuronal activity increases translocator protein (TSPO) levels

(2020) Tina Notter et al.   MOLECULAR PSYCHIATRY

Comparison of bacterial lipopolysaccharide-induced sickness behavior in rodents and humans: relevance for symptoms of anxiety and depression

(2020) Julie Lasselin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers

(2020) M. A. Nettis et al.   Translational Psychiatry

Transcriptomic predictors of inflammation-induced depressed mood

(2019) Joshua Hyong-Jin Cho et al.   NEUROPSYCHOPHARMACOLOGY

The neuroactive potential of the human gut microbiota in quality of life and depression

(2019) Mireia Valles-Colomer et al.   Nature Microbiology

Animal models of major depressive disorder and the implications for drug discovery and development

(2019) Konstantin A. Demin et al.   Expert Opinion on Drug Discovery

Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

(2019) Daniela Enache et al.   BRAIN BEHAVIOR AND IMMUNITY

Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [11C]PBR28 positron emission tomography

(2019) A. Forsberg et al.   JOURNAL OF NEUROIMMUNOLOGY

Fatigue and sleepiness responses to experimental inflammation and exploratory analysis of the effect of baseline inflammation in healthy humans

(2019) Julie Lasselin et al.   BRAIN BEHAVIOR AND IMMUNITY

The neurobiology of interoception in health and disease

(2018) Lisa Quadt et al.   Annals of the New York Academy of Sciences

Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study

(2018) Sophie E. Holmes et al.   BIOLOGICAL PSYCHIATRY

Harnessing Gut Microbes for Mental Health: Getting From Here to There

(2018) Annadora J. Bruce-Keller et al.   BIOLOGICAL PSYCHIATRY

Exercise reduces depression and inflammation but intensity matters

(2018) Emily M. Paolucci et al.   BIOLOGICAL PSYCHOLOGY

Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [ 11 C]PBR28 PET study

(2018) Sandra Tamm et al.   BRAIN BEHAVIOR AND IMMUNITY

Low-grade inflammation decreases emotion recognition – Evidence from the vaccination model of inflammation

(2018) Leonie J.T. Balter et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of psychological interventions on systemic levels of inflammatory biomarkers in humans: A systematic review and meta-analysis

(2018) M.S. O'Toole et al.   BRAIN BEHAVIOR AND IMMUNITY

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

(2018) Marco Del Giudice et al.   BRAIN BEHAVIOR AND IMMUNITY

Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis

(2018) Sarah R. Horn et al.   BRAIN BEHAVIOR AND IMMUNITY

Treatment-resistant depression and peripheral C-reactive protein

(2018) Samuel R. Chamberlain et al.   BRITISH JOURNAL OF PSYCHIATRY

Therapeutic Strategies for Treatment of Inflammation-related Depression

(2018) Miroslav Adzic et al.   Current Neuropharmacology

Sex differences in how inflammation affects behavior: What we can learn from experimental inflammatory models in humans

(2018) Julie Lasselin et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials

(2018) Joshua D. Rosenblat et al.   JOURNAL OF AFFECTIVE DISORDERS

What does plasma CRP tell us about peripheral and central inflammation in depression?

(2018) Jennifer C. Felger et al.   MOLECULAR PSYCHIATRY

Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder

(2018) Ebrahim Haroon et al.   PSYCHONEUROENDOCRINOLOGY

Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study

(2018) Emanuele F. Osimo et al.   PSYCHONEUROENDOCRINOLOGY

PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

(2018) Erica M. Richards et al.   EJNMMI Research

What’s CRP got to do with it? Tackling the complexities of the relationship between CRP and depression

(2018) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Sickness behavior is not all about the immune response: Possible roles of expectations and prediction errors in the worry of being sick

(2018) Julie Lasselin et al.   BRAIN BEHAVIOR AND IMMUNITY

Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies

(2018) Thomas E. Kraynak et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation

(2018) Larissa N. Dooley et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report

(2018) Timothy A. Allen et al.   PSYCHOLOGICAL MEDICINE

Food for Mood: Relevance of Nutritional Omega-3 Fatty Acids for Depression and Anxiety

(2018) Thomas Larrieu et al.   Frontiers in Physiology

Moderators for depressed mood and systemic and transcriptional inflammatory responses: a randomized controlled trial of endotoxin

(2018) Michael R. Irwin et al.   NEUROPSYCHOPHARMACOLOGY

Sex differences in the pro-inflammatory cytokine response to endotoxin unfold in vivo but not ex vivo in healthy humans

(2017) Alexander Wegner et al.   Innate Immunity

NLRP3 Inflammasome Contributes to Lipopolysaccharide-induced Depressive-Like Behaviors via Indoleamine 2,3-dioxygenase Induction

(2017) Seon-A Jeon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Minocycline as an adjunct for treatment-resistant depressive symptoms: A pilot randomised placebo-controlled trial

(2017) Muhammad I Husain et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry

(2017) T Notter et al.   MOLECULAR PSYCHIATRY

Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms

(2017) H Engler et al.   MOLECULAR PSYCHIATRY

Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis

(2017) S P Leighton et al.   MOLECULAR PSYCHIATRY

Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans

(2017) Amelia Draper et al.   NEUROPSYCHOPHARMACOLOGY

Interferon-alpha-Induced Changes in NODDI Predispose to the Development of Fatigue

(2017) N.G. Dowell et al.   NEUROSCIENCE

Yawning, a thermoregulatory mechanism during fever? A study of yawning frequency and its predictors during experimentally induced sickness

(2017) Alexandre Marraffa et al.   PHYSIOLOGY & BEHAVIOR

Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin

(2017) D. Kiers et al.   Scientific Reports

Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults

(2017) J A Bell et al.   Translational Psychiatry

Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome

(2017) D D Kiraly et al.   Translational Psychiatry

Effects of acute systemic inflammation on the interplay between sad mood and affective cognition

(2017) Sven Benson et al.   Translational Psychiatry

Acute Changes in Striatal Microstructure Predict the Development of Interferon-Alpha Induced Fatigue

(2016) Nicholas G. Dowell et al.   BIOLOGICAL PSYCHIATRY

A Neurocomputational Account of How Inflammation Enhances Sensitivity to Punishments Versus Rewards

(2016) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Intrinsic functional connectivity of insular cortex and symptoms of sickness during acute experimental inflammation

(2016) Mats Lekander et al.   BRAIN BEHAVIOR AND IMMUNITY

Interferon-α acutely impairs whole-brain functional connectivity network architecture – A preliminary study

(2016) Ottavia Dipasquale et al.   BRAIN BEHAVIOR AND IMMUNITY

Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms

(2016) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior

(2016) Julie Lasselin et al.   BRAIN BEHAVIOR AND IMMUNITY

Alterations in functional connectivity of resting state networks during experimental endotoxemia – An exploratory study in healthy men

(2016) Franziska Labrenz et al.   BRAIN BEHAVIOR AND IMMUNITY

Exposure to an inflammatory challenge enhances neural sensitivity to negative and positive social feedback

(2016) Keely A. Muscatell et al.   BRAIN BEHAVIOR AND IMMUNITY

Why sickness hurts: A central mechanism for pain induced by peripheral inflammation

(2016) B. Karshikoff et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation in Depression and the Potential for Anti-Inflammatory Treatment

(2016) Ole Kohler et al.   Current Neuropharmacology

Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions

(2016) N Kappelmann et al.   MOLECULAR PSYCHIATRY

Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial

(2016) Julie Lasselin et al.   NEUROPSYCHOPHARMACOLOGY

The Role of Brain Structure and Function in the Association Between Inflammation and Depressive Symptoms

(2016) Michelle L. Byrne et al.   PSYCHOSOMATIC MEDICINE

Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression

(2015) Jian-jun Yang et al.   BIOLOGICAL PSYCHIATRY

The role of the ventral striatum in inflammatory-induced approach toward support figures

(2015) Tristen K. Inagaki et al.   BRAIN BEHAVIOR AND IMMUNITY

Neural circuitry mediating inflammation-induced central pain amplification in human experimental endotoxemia

(2015) Sven Benson et al.   BRAIN BEHAVIOR AND IMMUNITY

Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women

(2015) T.E. Lacourt et al.   BRAIN BEHAVIOR AND IMMUNITY

Modality and sex differences in pain sensitivity during human endotoxemia

(2015) B. Karshikoff et al.   BRAIN BEHAVIOR AND IMMUNITY

Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings

(2015) Ebrahim Haroon et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory cytokine-associated depression

(2015) Francis E. Lotrich   BRAIN RESEARCH

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Sex Differences in Depressive and Socioemotional Responses to an Inflammatory Challenge: Implications for Sex Differences in Depression

(2015) Mona Moieni et al.   NEUROPSYCHOPHARMACOLOGY

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

(2015) Christine M. Sandiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trait sensitivity to social disconnection enhances pro-inflammatory responses to a randomized controlled trial of endotoxin

(2015) Mona Moieni et al.   PSYCHONEUROENDOCRINOLOGY

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Human Endotoxin Administration as an Experimental Model in Drug Development

(2014) A F Suffredini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sex differences in anxiety and depression clinical perspectives

(2014) Margaret Altemus et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Lipopolysaccharide Reduces Incentive Motivation While Boosting Preference for High Reward in Mice

(2014) Elisabeth G Vichaya et al.   NEUROPSYCHOPHARMACOLOGY

Effects of Centrally Administered Etanercept on Behavior, Microglia and Astrocytes in Mice Following a Peripheral Immune Challenge

(2014) Marie lou Camara et al.   NEUROPSYCHOPHARMACOLOGY

The Effects of Mind-Body Therapies on the Immune System: Meta-Analysis

(2014) Nani Morgan et al.   PLoS One

Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life

(2014) Golam M. Khandaker et al.   JAMA Psychiatry

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Endotoxin-induced experimental systemic inflammation in humans: A model to disentangle immune-to-brain communication

(2013) Manfred Schedlowski et al.   BRAIN BEHAVIOR AND IMMUNITY

Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers

(2013) Jane F. Ferguson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Experimental human endotoxemia enhances brain activity during social cognition

(2013) Jennifer S. Kullmann et al.   Social Cognitive and Affective Neuroscience

Functional Neuroimaging of Major Depressive Disorder: A Meta-Analysis and New Integration of Baseline Activation and Neural Response Data

(2012) J. Paul Hamilton et al.   AMERICAN JOURNAL OF PSYCHIATRY

Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration

(2012) Lucile Capuron et al.   ARCHIVES OF GENERAL PSYCHIATRY

Bupropion pre-treatment of endotoxin-induced depressive symptoms

(2012) Nicole DellaGioia et al.   BRAIN BEHAVIOR AND IMMUNITY

Neural response to emotional stimuli during experimental human endotoxemia

(2012) Jennifer S. Kullmann et al.   HUMAN BRAIN MAPPING

Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans

(2012) J. Hannestad et al.   JOURNAL OF NUCLEAR MEDICINE

Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

(2012) Jonas Hannestad et al.   NEUROIMAGE

Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration

(2012) Yuta Ohgi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Distinct Contributions of the Dorsolateral Prefrontal and Orbitofrontal Cortex during Emotion Regulation

(2012) Armita Golkar et al.   PLoS One

Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

(2012) Marie Kim Wium-Andersen et al.   JAMA Psychiatry

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Calorie restriction attenuates LPS-induced sickness behavior and shifts hypothalamic signaling pathways to an anti-inflammatory bias

(2011) Leah MacDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inflammation selectively enhances amygdala activity to socially threatening images

(2011) Tristen K. Inagaki et al.   NEUROIMAGE

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

(2011) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Immune system to brain signaling: Neuropsychopharmacological implications

(2011) Lucile Capuron et al.   PHARMACOLOGY & THERAPEUTICS

Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans

(2011) Jan-Sebastian Grigoleit et al.   PLoS One

Effects of sleep and circadian rhythm on the human immune system

(2010) Tanja Lange et al.   Annals of the New York Academy of Sciences

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Inflammation and social experience: An inflammatory challenge induces feelings of social disconnection in addition to depressed mood

(2010) Naomi I. Eisenberger et al.   BRAIN BEHAVIOR AND IMMUNITY

Citalopram reduces endotoxin-induced fatigue

(2010) Jonas Hannestad et al.   BRAIN BEHAVIOR AND IMMUNITY

Interoception in anxiety and depression

(2010) Martin P. Paulus et al.   Brain Structure & Function

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Neural Origins of Human Sickness in Interoceptive Responses to Inflammation

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

An fMRI study of cytokine-induced depressed mood and social pain: The role of sex differences

(2009) Naomi I. Eisenberger et al.   NEUROIMAGE

A critical review of human endotoxin administration as an experimental paradigm of depression

(2009) Nicole DellaGioia et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Activation of Central Nervous System Inflammatory Pathways by Interferon-Alpha: Relationship to Monoamines and Depression

(2008) Charles L. Raison et al.   BIOLOGICAL PSYCHIATRY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE