Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 96, Issue 4, Pages 418-422Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2014.146
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Funding
- Intramural NIH HHS Funding Source: Medline
- NCATS NIH HHS [UL1TR001117] Funding Source: Medline
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Linking human physiology to inflammatory mechanisms discovered in vitro or in animal models is essential to determine their importance. Innate immunity underlies many of these inflammatory responses in health and disease. Bacterial endotoxin is the quintessential trigger of innate immune responses. When administered to humans, endotoxin has been an important means of demonstrating key inflammatory mechanisms in vivo. Furthermore, endotoxin challenges have provided opportunities to test the effects of novel inflammation-modifying agents in humans.
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