MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis

(2020) Ya-chao Wang et al.   STROKE

Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression

(2020) Qiang Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The post-cardiac arrest syndrome: A case for lung–brain coupling and opportunities for neuroprotection

(2019) Nguyen Mai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

(2019) Pu Hong et al.   Journal of Neuroinflammation

CA1-projecting subiculum neurons facilitate object–place learning

(2019) Yanjun Sun et al.   NATURE NEUROSCIENCE

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

Hypothermia Inhibits Cerebral Necroptosis and NOD-Like Receptor Pyrin Domain Containing 3 Pathway in a Swine Model of Cardiac Arrest

(2019) Anyu Qian et al.   JOURNAL OF SURGICAL RESEARCH

MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury

(2018) Saifudeen Ismael et al.   JOURNAL OF NEUROTRAUMA

Out-of-hospital cardiac arrest: in-hospital intervention strategies

(2018) Christian Hassager et al.   LANCET

Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis

(2018) Zhiwen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Aging Is Associated With Impaired Activation of Protein Homeostasis‐Related Pathways After Cardiac Arrest in Mice

(2018) Yuntian Shen et al.   Journal of the American Heart Association

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

Early Effects of Prolonged Cardiac Arrest and Ischemic Postconditioning during Cardiopulmonary Resuscitation on Cardiac and Brain Mitochondrial Function in Pigs

(2017) Timothy R. Matsuura et al.   RESUSCITATION

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection

(2017) Joaquín Amores-Iniesta et al.   Cell Reports

The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients

(2015) Kim Timmermans et al.   CRITICAL CARE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease

(2013) Dominic De Nardo et al.   AMERICAN JOURNAL OF PATHOLOGY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY