PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis

Postacute Delivery of GABA A α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling

(2018) Ya-chao Wang et al.   STROKE

Aging Is Associated With Impaired Activation of Protein Homeostasis‐Related Pathways After Cardiac Arrest in Mice

(2018) Yuntian Shen et al.   Journal of the American Heart Association

Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research

(2018) Zhuoran Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis

(2017) Wei Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

XBP1 (X-Box–Binding Protein-1)–Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G

(2017) Meng Jiang et al.   STROKE

Unfolded protein response in brain ischemia: A timely update

(2016) Wei Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome

(2016) Zhui Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmacological Inhibition of PERK Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats Through the Activation of Akt

(2016) Feng Yan et al.   MOLECULAR NEUROBIOLOGY

O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress

(2015) Shuai Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

(2014) Zhao V. Wang et al.   CELL

Small Ubiquitin-Like Modifier 3–Modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-Like Modifier Transgenic Mice

(2014) Wei Yang et al.   STROKE

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

(2012) Mimi A. Trinh et al.   Cell Reports

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats

(2009) Venkata Prasuja Nakka et al.   NEUROTOXICITY RESEARCH