Article
Cell Biology
Hannah E. Walters, Konstantin E. Troyanovskiy, Alwin M. Graf, Maximina H. Yun
Summary: Salamanders are able to regenerate their limbs by modulating cellular plasticity and inducing cellular senescence, which can enhance muscle dedifferentiation and regeneration. Senescent cells promote myotube cell cycle re-entry and reversal of muscle identity through secreted factors, with the FGF-ERK signalling axis playing a critical role. This study highlights the beneficial role of cellular senescence in complex structure regeneration.
Article
Biochemistry & Molecular Biology
Alessandra Sacco, Laura Belloni, Lucia Latella
Summary: Senescence is a cellular state induced by internal or external stimuli, resulting in cell cycle arrest, morphological changes, and dysfunctions in mitochondrial and lysosomal functionality. Recent evidence suggests that senescent cells in vivo are a heterogeneous cell population due to different activated pathways and distinct microenvironmental contexts. Future research will focus on exploring the heterogeneity of senescent cells to map cell progression and study the therapeutic advantages of senolytic drugs.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Oncology
Hilah Gal, Julia Majewska, Valery Krizhanovsky
Summary: Cellular senescence, a stable form of cell cycle arrest with pronounced secretory activity, plays functional roles in both physiological and pathological conditions. Recent studies have shown its contribution to development, regeneration and reprogramming. Transient presence of senescent cells may be beneficial for tissue regeneration.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biology
Giacomo L. Glotzer, Pietro Tardivo, Elly M. Tanaka
Summary: The expression of fibroblast growth factors (Fgf) ligands in the Apical Ectodermal Ridge (AER) is a conserved feature of limb development in vertebrates. However, the axolotl, a salamander species, has a unique mesenchymal expression of key Fgf ligands in its developing and regenerating limb. This study investigates the hypothesis that alterations in transcription factors and Wnt signaling during evolution have resulted in this unique expression pattern in the axolotl. The results suggest that a shift in tissue responsiveness to canonical Wnt signaling from epidermis to mesenchyme is one contributing factor to the mesenchymal expression of Fgf ligands in the axolotl.
Article
Cell Biology
Alexander M. Lovely, Timothy J. Duerr, Qingchao Qiu, Santiago Galvan, S. Randal Voss, James R. Monaghan
Summary: The study shows that the Wnt signaling pathway plays a similar role in both limb development and limb regeneration in axolotl salamanders. This provides new insights into the interaction of Wnt signaling with other signaling pathways during salamander limb development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Tsuyoshi Takamura, Hiroshi Nagashima, Hitomi Matsunari, Shuichiro Yamanaka, Yatsumu Saito, Yoshitaka Kinoshita, Toshinari Fujimoto, Kei Matsumoto, Kazuaki Nakano, Hirotaka James Okano, Eiji Kobayashi, Takashi Yokoo
Summary: This study proposes a novel method of xenogeneic regenerative medicine for chronic kidney disease treatment by grafting porcine fetal kidneys injected with human renal progenitor cells. A cryopreserve system for fetal kidneys and renal progenitor cells was developed, and it was confirmed that cryopreserved fetal kidneys can grow and regenerate nephrons.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Chao Liu, Yong Wei, Yan Zhang
Summary: This research investigates the protective effect of Klotho on contrast-induced nephropathy (CIN). The findings suggest that Klotho treatment can effectively alleviate changes in renal tubular structure and function, and slow down nephrocyte senescence by regulating the Wnt/β-catenin pathway, thus protecting the kidney.
SCIENCE OF ADVANCED MATERIALS
(2023)
Article
Cell Biology
Maximina H. Yun
Summary: Salamanders exhibit extreme regenerative abilities and extraordinary longevity, making them valuable models for studying organismal senescence and the interplay between regeneration and ageing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oriane Guillermin, Nikolaos Angelis, Clara M. Sidor, Rachel Ridgway, Anna Baulies, Anna Kucharska, Pedro Antas, Melissa R. Rose, Julia Cordero, Owen Sansom, Vivian S. W. Li, Barry J. Thompson
Summary: Wnt signaling induces gradient proliferation of stem/progenitor cells along the intestinal axis, with YAP-TEAD acting as a key downstream effector. YAP regulates the sensitivity of crypt stem cells to apoptosis and cell proliferation during regeneration, and its nuclear localization is influenced by Src family kinase. The interaction between Wnt and Src-YAP signals plays a crucial role in driving intestinal regeneration.
Article
Biochemistry & Molecular Biology
Kento Takaya, Ayano Sunohara, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Hideko Kanazawa, Toru Asou, Kazuo Kishi
Summary: This study analyzed the expression and localization of Wnt proteins in a mouse fetal-wound-healing model and found their association with scar formation. The results indicated that Wnt signaling may be involved in wound healing and scar formation. Regulation of Wnt signaling could be a possible mechanism to control scar formation.
Review
Cell Biology
Mitsuharu Endo, Koki Kamizaki, Yasuhiro Minami
Summary: The Ror-family proteins, Ror1 and Ror2, play crucial roles in developmental morphogenesis, tissue regeneration, and age-related diseases. Their aberrant expression is implicated in diseases such as tissue fibrosis, atherosclerosis, neurodegenerative diseases, and cancers, making them potential therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Paola Confalonieri, Maria Concetta Volpe, Justin Jacob, Serena Maiocchi, Francesco Salton, Barbara Ruaro, Marco Confalonieri, Luca Braga
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with unknown cause, characterized by lung fibrosis and ultimately leading to death. The currently available treatments can only slow down the progression of fibrosis but cannot cure the disease. Recent studies have shifted the understanding of IPF pathogenesis from fibroblast-driven to epithelium-driven, where dysfunctional alveolar type II epithelial cells (ATII) are unable to support lung regeneration and promote abnormal epithelial-mesenchymal crosstalk. This article summarizes the main causes of ATII cell dysfunction, describes the known mechanisms of physiological lung regeneration, and reviews the most relevant clinical trials, emphasizing the urgency of developing new therapies for IPF that promote ATII-driven alveolar regeneration.
Article
Pathology
Zuo-Long Wu, Qi-Qi Xie, Tai-Cong Liu, Xing Yang, Guang-Zhi Zhang, Hai-Hong Zhang
Summary: Intervertebral disc degeneration (IVDD) is an age-related degenerative disease that is mainly caused by the activation of the Wnt pathway after birth, which accelerates the degeneration process of intervertebral discs. Targeting the Wnt pathway may be an effective strategy for the treatment of IVDD, as it plays a crucial role in the growth, development, and degeneration of intervertebral discs.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Jason Llaneras, Caitlyn C. Belza, Samuel Eisenstein, Marek K. Dobke
Summary: Senescent cells and fibrosis impact the regenerative capacity of skin, particularly in chronic non-healing wounds. This study explores potential senescence reversing techniques and proposes the use of exosomes loaded with senolytics for improving chronic wound healing.
Article
Orthopedics
Frank C. Ko, Meghan M. Moran, Ryan D. Ross, D. Rick Sumner
Summary: The study found that the activation of canonical Wnt signaling can accelerate intramembranous bone regeneration in male mice but has no effect on female mice.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)