Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses

Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling

(2020) Claire Y Ma et al.   eLife

A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells

(2019) Enas Abu Shah et al.   eLife

T cell cytolytic capacity is independent of initial stimulation strength

(2018) Arianne C. Richard et al.   NATURE IMMUNOLOGY

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses

(2018) Eddie C. Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of T cell sensitivity to antigen

(2018) Jesús A. Siller-Farfán et al.   IMMUNOLOGICAL REVIEWS

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+T cells

(2017) Fiamma Salerno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

(2016) Lindsay K. Ward-Kavanagh et al.   IMMUNITY

pMHC affinity controls duration of CD8 + T cell–DC interactions and imprints timing of effector differentiation versus expansion

(2016) Aleksandra J. Ozga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined Single-Cell Measurement of Cytokine mRNA and Protein Identifies T Cells with Persistent Effector Function

(2016) Benoit P. Nicolet et al.   JOURNAL OF IMMUNOLOGY

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

(2016) Melissa Lever et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Scales the T Cell Response?

(2016) Viveka Mayya et al.   TRENDS IN IMMUNOLOGY

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells

(2015) M. P. Tan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+T Cells

(2015) Judith Leitner et al.   JOURNAL OF IMMUNOLOGY

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naive CD8+ T cells

(2014) M. N. Navarro et al.   Science Signaling

T cell responses: naïve to memory and everything in between

(2013) Nathan D. Pennock et al.   ADVANCES IN PHYSIOLOGY EDUCATION

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

(2013) Jun Huang et al.   IMMUNITY

Cellular-Level Versus Receptor-Level Response Threshold Hierarchies in T-Cell Activation

(2013) Hugo A. van den Berg et al.   Frontiers in Immunology

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

(2013) Amandine Legat et al.   Frontiers in Immunology

Polyfunctional responses by human T cells result from sequential release of cytokines

(2011) Q. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation

(2011) O. Dushek et al.   Science Signaling

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells

(2009) Yoshihisa Kaizuka et al.   JOURNAL OF CELL BIOLOGY

Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion

(2009) M. S. Turner et al.   JOURNAL OF IMMUNOLOGY

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

(2009) A. Wyzgol et al.   JOURNAL OF IMMUNOLOGY