GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis

Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function

(2020) Quanli Yang et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury

(2019) Hua Zhang et al.   Science Bulletin

Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation

(2018) Danielle A. Chisolm et al.   Annual Review of Immunology

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A

(2018) Mingchao Wang et al.   IMMUNITY

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation

(2018) Ruifang Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α–Driven Keratinocyte Inflammation

(2018) Laura Israël et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17–Mediated Psoriasiform Skin Inflammation In Vivo

(2018) Mark Mellett et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

(2018) Zhuzhen Zhang et al.   NATURE MEDICINE

Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells

(2018) Michihito Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion

(2018) Xichun Xia et al.   Frontiers in Oncology

Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers

(2017) Arimichi Okazaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

(2017) Lindsey Araujo et al.   eLife

Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics

(2016) H. Kang et al.   BRITISH JOURNAL OF DERMATOLOGY

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

(2016) Robert S. Banh et al.   NATURE CELL BIOLOGY

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

(2016) Amira Elgogary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

(2016) Michael J. Lukey et al.   Nature Communications

Cytokines IL-17 and IL-22 in the host response to infection

(2016) Maria Valeri et al.   Pathogens and Disease

T Helper Cell Subsets in Clinical Manifestations of Psoriasis

(2016) Marco Diani et al.   Journal of Immunology Research

Psoriasis

(2016) Jacqueline E. Greb et al.   Nature Reviews Disease Primers

Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial

(2015) K. Papp et al.   BRITISH JOURNAL OF DERMATOLOGY

TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression

(2015) Hou-Pu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials

(2015) Christopher E M Griffiths et al.   LANCET

Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis

(2015) Mark Lebwohl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Action at a Distance: Allostery and the Development of Drugs to Target Cancer Cell Metabolism

(2014) Byron DeLaBarre et al.   CHEMISTRY & BIOLOGY

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

(2014) Conor Mc Guire et al.   Journal of Neuroinflammation

LC–MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment

(2014) Muhammad Anas Kamleh et al.   JOURNAL OF PROTEOME RESEARCH

Adalimumab retreatment successfully restores clinical response and health-related quality of life in patients with moderate to severe psoriasis who undergo therapy interruption

(2014) K.B. Gordon et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

(2014) Katharina M Jeltsch et al.   NATURE IMMUNOLOGY

T Cell Receptor-Dependent Activation of mTOR Signaling in T Cells Is Mediated by Carma1 and MALT1, But Not Bcl10

(2014) K. S. Hamilton et al.   Science Signaling

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Paracaspase MALT1 Deficiency Protects Mice from Autoimmune-Mediated Demyelination

(2013) C. Mc Guire et al.   JOURNAL OF IMMUNOLOGY

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

(2012) Lorena Fontan et al.   CANCER CELL

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

(2012) Anne Brüstle et al.   JOURNAL OF CLINICAL INVESTIGATION

Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors

(2012) Krupa Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Hiding under the skin: A welcome surprise in psoriasis

(2012) James G Krueger   NATURE MEDICINE

Hiding under the skin: Interleukin-17–producing γδ T cells go under the skin?

(2012) Burkhard Becher et al.   NATURE MEDICINE

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

(2011) Qingguo Ruan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Major Role of    T Cells in the Generation of IL-17+ Uveitogenic T Cells

(2009) Y. Cui et al.   JOURNAL OF IMMUNOLOGY

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

(2009) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Ustekinumab for chronic plaque psoriasis

(2008) Brenda L Bartlett et al.   LANCET