Transcriptomic analysis identifies Toll‐like and Nod‐like pathways and necroptosis in pulmonary arterial hypertension

RNA sequencing analysis of monocrotaline-induced PAH reveals dysregulated chemokine and neuroactive ligand receptor pathways

(2020) Genfa Xiao et al.   Aging-US

Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin

(2019) Lei Wang et al.   THORAX

Cathepsin S Promotes the Development of Pulmonary Arterial Hypertension

(2019) Chi-Jen Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension

(2019) Marco Mura et al.   RESPIROLOGY

Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension

(2018) Scott A. Barman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammasomes: a novel therapeutic target in pulmonary hypertension?

(2018) Tara Elizabeth Scott et al.   BRITISH JOURNAL OF PHARMACOLOGY

GeneMANIA update 2018

(2018) Max Franz et al.   NUCLEIC ACIDS RESEARCH

Role of Extracellular Matrix in the Pathogenesis of Pulmonary Arterial Hypertension

(2018) Thenappan Thenappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline

(2018) Wei Zhuang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Evidence for Fucoidan-P-selectin Axis as a Therapeutic Target on Hypoxia-induced Pulmonary Hypertension

(2018) Tatyana Novoyatleva et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia-induced activation of specific members of the NF-kB family and its relevance to pulmonary vascular remodeling

(2017) Hardik Patel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pathview Web: user friendly pathway visualization and data integration

(2017) Weijun Luo et al.   NUCLEIC ACIDS RESEARCH

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

Microarray analysis in pulmonary hypertension

(2016) Julia Hoffmann et al.   EUROPEAN RESPIRATORY JOURNAL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils

(2016) Simone Wicki et al.   Cell Death & Disease

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients

(2015) Julia Hoffmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension

(2015) Y.-T. Chang et al.   CARDIOVASCULAR RESEARCH

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Five-Year Outcomes of Patients Enrolled in the REVEAL Registry

(2015) Harrison W. Farber et al.   CHEST

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

PPARδ activation inhibits homocysteine-induced p22phox expression in EA.hy926 cells through reactive oxygen species/p38MAPK pathway

(2014) Gen-Fa Xiao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Circulating Collagen Biomarkers as Indicators of Disease Severity in Pulmonary Arterial Hypertension

(2014) Zeenat Safdar et al.   JACC-Heart Failure

Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation

(2013) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The monocrotaline model of pulmonary hypertension in perspective

(2011) Jose G. Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators

(2011) J. C. A. Broen et al.   ARTHRITIS AND RHEUMATISM

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases

(2011) Chen Xie et al.   NUCLEIC ACIDS RESEARCH

Toll-like receptor 4–deficient mice are resistant to chronic hypoxia-induced pulmonary hypertension

(2010) Karen C. Young et al.   EXPERIMENTAL LUNG RESEARCH

Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice

(2010) Joseph George et al.   JOURNAL OF HYPERTENSION

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension

(2009) Mark L. Ormiston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Reactivation of γHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin

(2007) Edda Spiekerkoetter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY