Prediction of acute inhalation toxicity using cytotoxicity data from human lung epithelial cell lines

In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay

(2019) Mi Ho Jeong et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

(2019) Arbel Artzy-Schnirman et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods

(2018) Thomas Loret et al.   Particle and Fibre Toxicology

Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity

(2018) Swapna Upadhyay et al.   TOXICOLOGICAL SCIENCES

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

(2018) Amy J. Clippinger et al.   TOXICOLOGY IN VITRO

MicroRNA regulatory networks reflective of polyhexamethylene guanidine phosphate-induced fibrosis in A549 human alveolar adenocarcinoma cells

(2018) Da Young Shin et al.   TOXICOLOGY LETTERS

Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

(2018) Jorid Sørli   ALTEX-Alternatives to Animal Experimentation

Medium throughput breathing human primary cell alveolus-on-chip model

(2018) Janick D. Stucki et al.   Scientific Reports

A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro

(2017) Kinga Balogh Sivars et al.   TOXICOLOGICAL SCIENCES

A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations

(2017) Jean Menotti et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro inflammatory effects of polyhexamethylene biguanide through NF-κB activation in A549 cells

(2017) Ha Ryong Kim et al.   TOXICOLOGY IN VITRO

Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing

(2017) Jon Hamm et al.   TOXICOLOGY IN VITRO

Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity

(2016) A. Hess et al.   TOXICOLOGY IN VITRO

Optimization of the CULTEX® radial flow system for in vitro investigation of lung damaging agents

(2016) Amelie Tsoutsoulopoulos et al.   TOXICOLOGY LETTERS

3D Reconstruction of the Human Airway Mucosa In Vitro as an Experimental Model to Study NTHi Infections

(2016) Pasquale Marrazzo et al.   PLoS One

Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions

(2015) Tewes Tralau et al.   ARCHIVES OF TOXICOLOGY

Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment

(2015) Maija Pesonen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation

(2015) Vasundhra Bahl et al.   TOXICOLOGICAL SCIENCES

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

(2014) John A. Hickman et al.   Biotechnology Journal

Didecyldimethylammonium chloride induces oxidative stress and inhibits cell growth in lung epithelial cells

(2014) Jung-Taek Kwon et al.   Molecular & Cellular Toxicology

Cytotoxicity and gene expression profiling of polyhexamethylene guanidine hydrochloride in human alveolar A549 cells

(2014) Ha-Na Jung et al.   TOXICOLOGY IN VITRO

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

H2O2 inhibits the growth of human pulmonary fibroblast cells by inducing cell death, GSH depletion and G1 phase arrest

(2013) WOO HYUN PARK   Molecular Medicine Reports

Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat

(2010) Panagiotis Mitsopoulos et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways

(2009) L. Muller et al.   Journal of the Royal Society Interface