Review
Pharmacology & Pharmacy
Zhiyou Yang, Junxin Liu, Shuai Wei, Jiahang Deng, Xinyue Feng, Shucheng Liu, Mingxin Liu
Summary: Alzheimer's disease is an ageing-related neurodegenerative disorder characterized by neuritic plaques and neurofibrillary tangles. Neuroinflammation, especially the activation of NLRP3 inflammasome, plays a crucial role in the pathogenesis of AD. Targeting NLRP3 inflammasome seems to be an efficient strategy for AD treatment through regulating brain immune microenvironment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Eun Sun Jung, Kyujin Suh, Jihui Han, Heyyoung Kim, Hyung-Sik Kang, Won-Seok Choi, Inhee Mook-Jung
Summary: The study reveals that amyloid-beta activates the NLRP3 inflammasome in microglia by activating Syk and inhibiting AMPK, leading to neuroinflammation. Additionally, flufenamic acid (FA), a non-steroidal anti-inflammatory drug, effectively inhibits microglial activation of the NLRP3 inflammasome by regulating Syk and AMPK, offering a potential treatment for AD.
Article
Neurosciences
Bernardino Ossola, Ali Rifat, Anna Rowland, Helen Hunter, Samuel Drinkall, Clare Bender, Mayida Hamlischer, Martin Teall, Russell Burley, Daneil F. Barker, David Cadwalladr, Louise Dickson, Jason M. K. Lawrence, Jenna R. M. Harvey, Marina Lizio, Xiao Xu, Edel Kavanagh, Toni Cheung, Steve Sheardown, Catherine B. Lawrence, Michael Harte, David Broughe, Christian Madry, Kim Matthews, Kevin Doyle, Keith Page, Justin Powell, Nicola L. Brice, Roland W. Buerli, Mark B. Carlton, Lee A. Dawson
Summary: Neuroinflammation, particularly through the NLRP3 inflammasome cascade, plays a significant role in neurodegenerative diseases. The upregulation of THIK-1 in isolated microglia from the brains of Alzheimer's disease patients and the selective inhibitor C101248 can attenuate the release of IL-1 beta from microglia, suggesting THIK-1 as a potential therapeutic target for neuroinflammation modulation in AD.
Article
Immunology
Jahirul Islam, Jung-Ah Cho, Ju-Yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C. Kim, Kyung-Hwa Lee, Seung-Yong Seong
Summary: This study demonstrates that inhibiting the activation of N3I by targeting P2X7R with taurodeoxycholate (TDCA), a GPCR19 ligand, can alleviate neuroinflammation in Alzheimer's disease (AD). TDCA reduces the number of A beta plaques, enhances A beta phagocytosis, and improves pathological and cognitive functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wang
Summary: Recent studies have shown that the excessive activation of microglia and release of pro-inflammatory cytokines play crucial roles in the pathogenesis and progression of Parkinson's disease (PD). The elevated level of NLRP3 inflammasome in activated microglia in the substantia nigra of PD patients exacerbates the pathology and accelerates disease progression. Current therapeutic drugs for PD primarily focus on relieving clinical symptoms, as there are no established strategies to stop or reverse the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Tao Liang, Yang Zhang, Suyuan Wu, Qingjie Chen, Lin Wang
Summary: Alzheimer's disease is a common age-related neurodegenerative disease with characteristic pathological features, and the activation of NLRP3 inflammasome plays a crucial role in its pathogenesis. Chronic neuroinflammation is an important factor in the development of AD, and targeting NLRP3 inflammasome pharmacologically can provide new therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Mingde Fan, Chao Wang, Xueying Zhao, Yang Jiang, Chengwei Wang
Summary: Parthenolide (PTL) treatment improved cognitive impairment in APP/PS1 mice by inhibiting neuroinflammation. PTL reduced intracellular reactive oxygen species and restored microglial phagocytosis via the AKT/MAPK/NF-kappa B signaling pathway. Additionally, PTL enhanced TRIM31 expression and attenuated the NLRP3 signaling, exerting anti-inflammatory effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Charlotte Braatz, Max P. Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Roisin M. McManus, Michael T. Heneka
Summary: Alzheimer's disease (AD) is characterized by the deposition of Amyloid-beta (Aβ) peptide, which leads to NLRP3 inflammasome activation and the release of interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). NLRP3-directed antisense oligonucleotides (ASOs) have been found to suppress NLRP3 inflammasome activity and IL-1β release in primary murine microglia and human THP-1 cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Neurosciences
Qiu-Qin Han, Weidong Le
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopamine neurons and the formation of Lewy bodies. Alpha-synuclein and the NLRP3 inflammasome play crucial roles in neuroinflammation in PD. Understanding the molecular mechanisms and targeting strategies of the NLRP3 inflammasome may contribute to the development of effective therapies for PD.
NEUROSCIENCE BULLETIN
(2023)
Article
Immunology
Jia-Mei Li, Ting Hu, Xiao-Na Zhou, Ting Zhang, Jia-Hui Guo, Min-Yuan Wang, Yi-Lin Wu, Wen-Jun Su, Chun-Lei Jiang
Summary: Inhibiting NLRP3 inflammasome expression can improve depressive-like behaviors in mice and this study aimed to understand its impact on cognitive decline in depression and explore the common neuro-immunological mechanisms of depression and Alzheimer's disease (AD).
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Xiaojuan Han, Tianshu Xu, Qijun Fang, Huajun Zhang, Lijun Yue, Gang Hu, Lingyun Sun
Summary: This study demonstrated that Quercetin inhibits NLRP3 inflammasome activation in microglia by promoting mitophagy, thus preventing neuronal injury and providing a potential novel therapeutic strategy for neuroinflammation-related diseases.
Review
Biochemistry & Molecular Biology
Ming-Lei Guo, Soheil Kazemi Roodsari, Yan Cheng, Rachael Elizabeth Dempsey, Wenhui Hu
Summary: In the past decade, substance use disorders (SUDs) have been recognized as brain diseases related to neuroinflammation. Abused drugs can modulate microglia activation and neuroinflammation levels, which contribute to the development of SUDs. Various neuroimmune signaling pathways, including TLR/NF-kB, reactive oxygen species, mitochondria dysfunction, and autophagy defection, have been implicated in promoting SUDs. NLRP3 inflammasome, a critical component in microglia activation, has been identified as a potential target for mitigating the development of SUDs.
Article
Clinical Neurology
Wen-Jun Su, Jia-Mei Li, Ting Zhang, Zhi-Yong Cao, Ting Hu, Shi-Yang Zhong, Zhang-Yang Xu, Hong Gong, Chun-Lei Jiang
Summary: This study aims to elucidate the neuroimmune mechanism of diabetes-related depression. The activation of NLRP3 inflammasome, mainly in hippocampal microglia, mediates the development of depression-like behaviors in STZ-induced diabetic mice. Targeting the microglial inflammasome is a feasible strategy for the treatment of diabetes-related depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Plant Sciences
Zhiwei Xu, Xiaojie Zhou, Xiao Hong, Sichen Wang, Jiale Wei, Junhao Huang, Liting Ji, Yuanxiao Yang, Thomas Efferth, Chunlan Hong, Changyu Li
Summary: In this study, it was found that Shi chang pu (SCP-oil) can improve cognitive impairment, reduce pathological damage, and inhibit neuroinflammation in AD mice. This neuroprotective effect is achieved through the inhibition of the NF-kappa B signaling pathway and reduced activation of the NLRP3 inflammasome.
Article
Health Care Sciences & Services
Ming-Lei Guo, Ernest T. Chivero, Shannon E. Callen, Shilpa Buch
Summary: Microglia, the primary immunocompetent cells in the brain, might play a role in drug addiction by promoting inflammation through factors like IL1 beta; findings showed that CX3CR1 deficiency could enhance NLRP3 inflammasome activity, leading to behavioral changes in response to cocaine; the study demonstrated the impact of microglia functional status on cocaine reward effects and suggested targeting the NLRP3 inflammasome as a potential therapeutic approach for drug addiction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Ni-Hong Chen, Yi-Ming Zhang, Fu-Ping Jiang, Shen Liu, Hong-Dong Zhao, Jian-Kang Hou, Teng Jiang, Jian-Quan Shi, Jun-Shan Zhou, Ying-Dong Zhang
Summary: Fluid-attenuated inversion recovery vascular hyperintensity (FVH) predicts early neurological deterioration (END) but not hemorrhagic transformation (HT) in acute ischemic stroke (AIS) patients receiving endovascular thrombectomy.
NEUROLOGICAL SCIENCES
(2022)
Review
Genetics & Heredity
Manqiqige Su, Xiaoqing Liu, Liang Wang, Jie Song, Zhirui Zhou, Sushan Luo, Chongbo Zhao
Summary: The proportion of pregnancy-related worsening in MG patients is 0.36 in total, 0.23 during the antepartum period, and 0.11 in the postpartum period. The proportion of pregnancy-related improvement in MG patients is 0.07 during pregnancy and 0.14 after pregnancy. There are no significant associations between clinical factors and MG worsening, but thymectomy before delivery is a strong predictor for postpartum improvement in MG patients.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Clinical Neurology
Zhaohan Xu, Nihong Chen, Huiling Sun, Teng Jiang, Qiwen Deng, Junshan Zhou, Yingdong Zhang
Summary: This study aimed to investigate the effect of dual antiplatelet therapy on patients with minor ischemic stroke receiving intravenous thrombolysis. The results showed that dual antiplatelet therapy was associated with better outcomes in terms of the modified Rankin Scale at 90 days, without significant adverse events.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Li Gao, Jie-Xing Qin, Jian-Quan Shi, Teng Jiang, Fei Wang, Chong Xie, Qing Gao, Nan Zhi, Qing Dong, Yang-Tai Guan
Summary: This study aimed to investigate the role and mechanisms of NLRP3 inflammasome and pyroptosis in ischemic stroke after PM2.5 exposure. The results showed that PM2.5 exposure decreased cell viability and aggravated NLRP3 inflammasome activation and pyroptosis. It was also found that PM2.5 exposure increased intracellular ROS production. These findings provide insights into the mechanisms of PM2.5-induced toxic effects after ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Chengfang Liu, Xiaohui Li, Zhaohan Xu, Yishan Wang, Teng Jiang, Meng Wang, Qiwen Deng, Junshan Zhou
Summary: This study investigated the influence of hyperglycaemia on acute kidney injury (AKI) after endovascular treatment (EVT) in acute ischaemic stroke patients. A glycaemia-based nomogram was established to predict the risk of AKI, with confirmed net benefit by decision curve analysis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Ting Huang, Jin-Ying Zhao, Rong-Rong Pan, Teng Jiang, Xin-Xin Fu, Qing Huang, Xi-Xi Wang, Peng-Yu Gong, You-Yong Tian, Ying-Dong Zhang
Summary: By constructing a PD-specific ceRNA network and verifying differentially expressed lncRNAs, this study identified LINC01259 as a potential immune and inflammatory biomarker for the diagnosis of PD and early-stage PD. The expression of LINC01259 was significantly lower in PD patients, particularly among male patients. The findings provide further evidence for the dysregulation of lncRNAs in PD patients' circulating leukocytes.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Xiaohao Zhang, Feng Zhou, Wei Wang, E. Yan, Shuaiyu Chen, Haiming Cao, Huiwen Lian, Teng Jiang, Yingdong Zhang, Hongchao Shi, Junshan Zhou
Summary: This study found a significant association between levels of adhesion molecules and poor outcome in patients treated with mechanical thrombectomy, which was partially mediated by symptomatic intracranial hemorrhage.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Xin-Xin Fu, Rui Duan, Si-Yu Wang, Qiao-Quan Zhang, Bin Wei, Ting Huang, Peng-Yu Gong, Yan E, Teng Jiang, Ying-Dong Zhang
Summary: This study found that lamotrigine treatment can improve cognitive function and pathological damage related to Alzheimer's disease. The beneficial effects may be mediated by the regulation of specific gene expression in the brain. These results suggest that lamotrigine may be a promising therapeutic drug for Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2023)
Article
Cell Biology
Si-Yu Wang, Xin-Xin Fu, Rui Duan, Bin Wei, Hai-Ming Cao, E. Yan, Shuai-Yu Chen, Ying-Dong Zhang, Teng Jiang
Summary: This study provides evidence that TREML2 modulates inflammation by regulating microglial polarization and NLRP3 inflammasome activation, suggesting a novel therapeutic strategy for Alzheimer's disease (AD).
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Hai-Ming Cao, Hui-Wen Lian, Yan E, Rui Duan, Jun-Shan Zhou, Xiang-Liang Chen, Teng Jiang
Summary: The long-term effect of dual antiplatelet therapy (DAPT) using clopidogrel plus aspirin versus aspirin monotherapy after intravenous thrombolysis on functional outcomes in patients with minor stroke was investigated. The study found that DAPT was associated with improved functional outcome at the 1-year follow-up for patients with minor stroke, without increasing the stroke recurrence rate and mortality.
Article
Neurosciences
Xin-Xin Fu, Bin Wei, Hai-Ming Cao, Rui Duan, Yang Deng, Hui-Wen Lian, Ying-Dong Zhang, Teng Jiang
Summary: TEL has shown promising effects in the prevention and treatment of AD. It improves cognitive and executive impairments, reduces neuronal and synaptic injury, Aβ pathology, neuroinflammation, and oxidative stress. The beneficial effects of TEL are achieved by inhibiting Aβ production and promoting Aβ degradation, as well as through its anti-inflammatory effects via microglial pathways. Early administration of TEL can also prevent the onset of AD-related symptoms.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Xin-Xin Fu, Shuai-Yu Chen, Hui-Wen Lian, Yang Deng, Rui Duan, Ying-Dong Zhang, Teng Jiang
Summary: Previously, the H157Y variant of the TREM2 gene was found to be associated with increased risk of Alzheimer's disease (AD) in Han Chinese population. In this study, using CRISPR-Cas9-engineered BV2 microglia, researchers investigated the effect of the Trem2 H157Y variant on AD-related microglial functions. The findings showed that this variant inhibits microglial phagocytosis, promotes M1-type polarization, and enhances the release of inflammatory cytokines.
Article
Neurosciences
Sheng Chen, Xiao Huan, Chun-Zuan Xu, Su-Shan Luo, Chong-Bo Zhao, Hua-Hua Zhong, Xue-Ying Zheng, Kai Qiao, Yi Dong, Ying Wang, Chang-Yun Liu, Hua-Pin Huang, Yan Chen, Zhang-Yu Zou
Summary: This study aimed to clarify the role of Eomesodermin (EOMES) as a disease-relevant biomarker and the intracellular molecules underlying the immunophenotype shifting of CD4+T subsets in amyotrophic lateral sclerosis (ALS). The results showed that increased CD4(+)EOMES(+)T-cell subsets in ALS were associated with disease progression and poor prognosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Huahua Zhong, Xiao Huan, Rui Zhao, Manqiqige Su, Chong Yan, Jie Song, Jianying Xi, Chongbo Zhao, Feifei Luo, Sushan Luo
Summary: This study identified a unique subset of monocytes, called monocytes 3, which showed significant differential expression of pro-inflammatory signaling pathways during and after a myasthenic crisis (MC). Additionally, a high neutrophil-lymphocyte ratio (NLR) was associated with MG-relevant clinical scores, indicating an activated innate immune state during MC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xiaohao Zhang, Pengyu Gong, Ying Zhao, Ting Wan, Kang Yuan, Yunyun Xiong, Min Wu, Mingming Zha, Yunzi Li, Teng Jiang, Xinfeng Liu, Ruidong Ye, Yi Xie, Gelin Xu
Summary: This study investigated the role of endothelial Caveolin-1 (Cav-1) in thrombo-inflammation in ischemic stroke. The results showed that reduced Cav-1 levels were associated with increased thrombo-inflammation, microthrombosis formation, and myeloid cell infiltration. Enhancing endothelial Cav-1 expression alleviated thrombo-inflammation and improved neurological recovery in stroke.
