Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Rong Tan, Huiwei Dong, Zhengshan Chen, Min Jin, Jing Yin, Haibei Li, Danyang Shi, Yifan Shao, Huaran Wang, Tianjiao Chen, Dong Yang, Junwen Li
Summary: Unhealthy dietary habits are associated with increased incidence of chronic diseases, with high-fat and high-fructose diets leading to reduced defecation volume, increased levels of pro-inflammatory cytokines and IgG in serum, inflammatory cell infiltration in intestinal tissue, changes in microbial composition, alterations in microbial metabolites, and potential causes of constipation and inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Food Science & Technology
Li Li, Jionghao Chen, Haoming Sun, Qiang Niu, Yan Zhao, Xiaojun Yang, Qingzhu Sun
Summary: This study found that Orm2 deficiency exacerbates HFD-induced gut microbiota disturbance and intestinal inflammation, providing a novel insight into the therapeutic strategy of obesity focusing on complex bacterial flora rather than single probiotic administration.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Zijian Dai, Siqi Li, Yantong Meng, Qingyu Zhao, Yiyun Zhang, Zhuoma Suonan, Yuge Sun, Qun Shen, Xiaojun Liao, Yong Xue
Summary: This study demonstrated the anti-atherosclerosis effect of capsaicin and provided evidence for the critical role of gut microbiota in this process.
Article
Chemistry, Applied
Bowei Zhang, Yingchuan Xu, Huan Lv, Wenwen Pang, Jin Wang, Hui Ma, Shuo Wang
Summary: This study investigated the intestinal pharmacokinetics of resveratrol in mice using HPLC-MS/MS and found that resveratrol and its metabolites were present in significant amounts in the entire intestinal tract and feces, with a peak concentration at 4 hours post-administration. The study also demonstrated the promotion of Lactobacillus reuteri growth by resveratrol-3-O-sulfate during in vitro fermentation and the up-regulation of tight junction and mucin-related proteins mRNA expressions by resveratrol-3-O-sulfate during incubation with Caco-2 cells.
Article
Agriculture, Multidisciplinary
Tunyu Jian, Lina Zhou, Yan Chen, Yuwen Tian, Ruoyun Wu, Bei Tong, Guanting Niu, Yanan Gai, Weilin Li, Jian Chen
Summary: In this study, we demonstrated that total sesquiterpenoids (TSs) from loquat leaves can treat obesity by modulating gut microbiota and related metabolites. TSs reduced body weight, white adipose tissue, total cholesterol (TC), and triglyceride (TG) levels in the serum. They also restored the diversity and richness of gut microbiota and affected the metabolism of the host. By identifying key differential metabolites, we confirmed the role of TSs in inhibiting obesity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Immunology
Jingyi Chen, Yu Wang, Yongxia Shi, Yongpan Liu, Chengyi Wu, Yanrong Luo
Summary: Intestinal ischemia/reperfusion (II/R) is a common acute and critical condition with a lack of effective prevention and treatment measures. The gut microbiota has been found to play a pivotal role in II/R, and maintaining the homeostasis of the gut microbiota and its metabolites may be a potential strategy for treatment. This review highlights the importance of the crosstalk between the gastrointestinal ecosystem and II/R, and discusses the potential applications of microbial-based therapies in II/R.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Nataliia Nikolaieva, Aneta Sevcikova, Radoslav Omelka, Monika Martiniakova, Michal Mego, Sona Ciernikova
Summary: Pre-clinical models and clinical studies have shown that the host-microbiota relationship has a significant impact on cancer development and treatment, leading to the emergence of a microbiota-based approach in clinical oncology. Polymorphic microbes are considered a hallmark of cancer, and microRNAs play a crucial role in gene expression regulation. Bidirectional gut microbiota-microRNA interactions have been found to be important for intestinal homeostasis and are associated with inflammatory responses and dysbiosis in gastrointestinal disorders. This review summarizes the current understanding of miRNA expression in the intestine, with a focus on gut microbiota-miRNA interactions related to intestinal homeostasis, the immune system, and cancer development. The potential clinical utility of fecal miRNA profiling as a diagnostic and prognostic tool in colorectal cancer is discussed, as well as the potential of gut microbiota modulation and personalized microRNA therapeutics in improving outcomes for patients with gastrointestinal cancer in the era of precision medicine.
Article
Nutrition & Dietetics
Zhengjie Wu, Jian Shen, Qiaomai Xu, Qiangqiang Xiang, Yunbo Chen, Longxian Lv, Beiwen Zheng, Qiangqiang Wang, Shuting Wang, Lanjuan Li
Summary: Clostridioides difficile infection is closely related to antibiotic-induced intestinal flora disorders, and the bioactive ingredient EGCG in green tea can alleviate C. difficile growth and improve intestinal microbiota, inflammation, and barrier function.
Article
Nutrition & Dietetics
Xinxin Ren, Jia Xu, Ye Xu, Qin Wang, Kunlun Huang, Xiaoyun He
Summary: This study investigates the potential mechanism of Artemether (ART) in diet-induced intestinal injury. The results suggest that ART intervention may alleviate intestinal barrier function disorders and inflammatory responses by restoring intestinal flora balance, increasing the expression of tight junction proteins, and decreasing the expression of pro-inflammatory factors. Moreover, ART intervention inhibits the activation of the TLR4/NF-kappa B p65 pathway in colon tissue, indicating a potential protective effect of ART on intestinal inflammation.
Article
Chemistry, Medicinal
Lijie Su, Yupeng Zeng, Guokun Li, Jing Chen, Xiaoyi Chen
Summary: Quercetin supplementation can reduce inflammation in obese mice induced by a high-fat diet by altering gut microbiota and metabolites.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dongmei Wang, Jieying Liu, Ling Zhong, Lu Ding, Qian Zhang, Miao Yu, Ming Li, Xinhua Xiao
Summary: The combined administration of metformin and pioglitazone has been shown to have protective effects on obese mice fed a high-fat diet. The study found that this combination therapy alters the gut microbiota and its metabolites, leading to improved glucolipid metabolism. The results provide novel evidence and potential targets for metformin and pioglitazone combination therapy in type 2 diabetes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Pan Huang, Anqi Jiang, Xuxin Wang, Yan Zhou, Weihong Tang, Caifang Ren, Xin Qian, Zhengrong Zhou, Aihua Gong
Summary: The study showed that long-term NMN treatment increased the abundance of beneficial bacteria such as butyric acid-producing bacteria and Akkermansia muciniphila, while decreasing harmful bacteria like Bilophila and Oscillibacter. It also increased the levels of bile acid-related metabolites in feces. Moreover, NMN treatment improved intestinal mucosal permeability by increasing goblet cell numbers, mucus thickness, and tight junction protein expression.
FRONTIERS IN NUTRITION
(2021)
Article
Biology
Nianyi Zeng, Fan Wu, Junqi Lu, Xiang Li, Shaomei Lin, Lang Zhou, Zhongwei Wang, Guangyan Wu, Qingfa Huang, Daowen Zheng, Jie Gao, Shan Wu, Xiaojiao Chen, Muxuan Chen, Fanguo Meng, Haitao Shang, Yan He, Peng Chen, Hong Wei, Zhuang Li, Hongwei Zhou
Summary: Gut barrier disruption is a key event linking gut microbiota dysbiosis and metabolic disorders caused by a high-fat diet. In this study, it was found that a high-fat diet instantly altered the gut microbiota composition and damaged the gut barrier. The high-fat diet induced gut microbiota to produce reactive oxygen species (ROS), which could be transferred to germ-free mice, leading to downregulation of gut barrier tight junctions. The study suggests that extracellular ROS derived from gut microbiota play a pivotal role in high-fat diet-induced gut barrier disruption and have potential as a therapeutic target for metabolic diseases.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Food Science & Technology
Zhengqi Liu, Yujiao Zhang, Chunqing Ai, Weigong Tian, Chengrong Wen, Shuang Song, Beiwei Zhu
Summary: The study isolated an acidic polysaccharide (SPYP) from the skirt of Patinopecten yessoensis and found that it has anti-obesity effects by reducing body weight, fat accumulation, and high blood lipids induced by a high-fat diet in mice. The modulation of gut microbiota and restoration of short-chain fatty acids by SPYP supplementation were key factors in its anti-obesity effect. Liquid chromatography-high resolution accurate mass spectrometry analysis showed that SPYP altered metabolite profiles in HFD-fed mice, particularly affecting lipid and amino acid metabolism.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Food Science & Technology
Yunting Xie, Yafang Ma, Linlin Cai, Shuai Jiang, Chunbao Li
Summary: Meat consumption varies widely among individuals, populations, and regions, and may not be the main cause of increasing chronic diseases. Unhealthy dietary habits and a sedentary lifestyle have a greater impact. Meat and meat products provide valuable protein and essential nutrients, and are still necessary for human health as long as excessive intake is avoided.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Food Science & Technology
Hao Li, Rui Zheng, Fangfang Zuo, Chengyu Qian, Zhengan Yao, Ruipeng Dong, Di Zhao, Chunbao Li
Summary: Proteolysis has a significant but complex influence on the binding capacity of myofibrillar proteins to flavor compounds.
Article
Food Science & Technology
Haoquan Jin, Yuxuan Wang, Bowen Lv, Kexin Zhang, Zhe Zhu, Di Zhao, Chunbao Li
Summary: In this study, a rapid and nondestructive method based on low-field nuclear magnetic resonance (LF-NMR) detection and chemometrics analysis was developed to detect adulterated avocado oil. The method showed high accuracy in distinguishing adulterated avocado oil from soybean oil (SO), corn oil (CO) or rapeseed oil (RO) adulterated avocado oil, and could accurately calculate the adulteration levels when avocado oil was adulterated by different oils.
Article
Nutrition & Dietetics
Chong Wang, Fan Zhao, Yun Bai, Chunbao Li, Xinglian Xu, Karsten Kristiansen, Guanghong Zhou
Summary: In this study, we evaluated the protective effects of six polyphenols on BaP-induced cytotoxicity in Caco-2 cells. Our results showed that eriodictyol was superior to naringenin in protecting against BaP-induced toxicity. Proteomics analysis revealed several key proteins involved in the protective mechanisms of eriodictyol.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Di Zhao, Kai Shan, Yunting Xie, Guanghong Zhang, Qi An, Xiaobo Yu, Guanghong Zhou, Chunbao Li
Summary: There is a relationship between meat consumption and gut diseases, with the gut microbiota playing an important role. Hosts with different body weight indexes (BMIs) may respond differently to meat-based diet alterations. Low-BMI volunteers showed greater sensitivity to meat-based diet alterations, while high- and middle-BMI volunteers showed greater sensitivity in fecal proteome profiles and blood indexes. The chicken-based diet decreased inflammation-related blood indexes, particularly in high- and middle-BMI volunteers.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Biochemistry & Molecular Biology
Fan Zhao, Zhenqian Wei, Yun Bai, Chunbao Li, Guanghong Zhou, Karsten Kristiansen, Chong Wang
Summary: This study investigated the changes in peptide and metabolite profiles in exudates from pork stored at different temperatures. The results suggest that these changes can be used as markers of pork spoilage.
Article
Food Science & Technology
Yafang Ma, Kai Shan, Zixin Huang, Di Zhao, Miao Zhang, Weixin Ke, Chunbao Li
Summary: High-fat diet alters colonic bile acid composition and impairs colonic barrier function. Secondary bile acids, especially isomerized derivatives, may play a protective role in maintaining colonic barrier function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Acoustics
Miao Zhang, Tingxuan Gao, Yu Han, Dejiang Xue, Shuai Jiang, Qian Li, Chunbao Li
Summary: This study investigated the acoustic conditions of ultrasound-assisted calcium lactate processing of collagen and found that ultrasound could decrease the particle size and increase the zeta potential of collagen. However, the increase in calcium lactate concentration could limit the effect of ultrasound processing.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Food Science & Technology
Miao Zhang, Shuran Zhu, Qian Li, Dejiang Xue, Shuai Jiang, Yu Han, Chunbao Li
Summary: Heat treatment affects the structural properties of meat proteins, which in turn leads to changes in their sensitivity to digestive enzymes, further affecting the nutritional value of meat and meat products. This study elucidates the effects of cooking temperature on the conformation of myosin and the change in digestibility of pepsin treatment during heating.
Article
Food Science & Technology
Miao Zhang, Kai Shan, Shangxin Song, Juan Bai, Ping Jiang, Di Zhao, Weixin Ke, Guanghong Zhou, Chunbao Li
Summary: Epidemiological studies have shown that excessive consumption of meat may lead to memory loss and cognitive decline. This study found that a high-chicken-protein diet had a negative impact on the enteric nervous system and hippocampal function. The higher levels of serine, glutamate, and proline in the high-chicken-protein diet inhibited amino acid absorption, reduced neurotransmitter levels, and increased hippocampal beta-secretase levels.
Article
Chemistry, Applied
Mengzhen Ding, Zixin Huang, Zhiji Huang, Zerun Zhao, Di Zhao, Kai Shan, Weixin Ke, Miao Zhang, Guanghong Zhou, Chunbao Li
Summary: This study investigated the digestion behaviors of high-fat and high-protein diets prepared with different protein sources using an in vitro digestion model. It was found that different protein sources can affect the efficiency of fat digestion, and myofibrillar proteins showed strong binding capacity to bile salts, thereby inhibiting fat digestion.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Kai Shan, Yuanyue Yao, Jingyi Wang, Tianming Zhou, Xianming Zeng, Miao Zhang, Weixin Ke, Hui He, Chunbao Li
Summary: In this study, the probiotic strain Bacillus cereus DM423 was used as a co-starter to improve the flavor of Lactiplantibacillus plantarum fermented sausage. The addition of DM423 enhanced protein and fat hydrolysis, resulting in the production of various flavor compounds. This research highlights the potential of using B. cereus DM423 as a co-starter for the development of fermented meat products.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Zhiji Huang, Yafang Ma, Yunting Xie, Di Zhao, Chunbao Li
Summary: The study found that supplementing kappa-CGN in high-fat diets can suppress weight gain and improve lipid metabolism. Kappa-CGN can upregulate the genes and protein expression of Sirtuin1, promote fatty acid oxidation, and inhibit lipid digestion and absorption, thereby reducing lipid accumulation and improving serum lipid profile.
Article
Food Science & Technology
Yunting Xie, Linlin Cai, Mengzhen Ding, Kai Shan, Di Zhao, Guanghong Zhou, Chunbao Li
Summary: The intake of plant-based meat analogues significantly enhances gastrointestinal motility function in mice. It also increases muscle layer thickness in the duodenum and jejunum, and promotes the activity of gastrointestinal cells. Additionally, plant-based meat analogues intake increases levels of appetite-stimulating factors and decreases levels of appetite-suppressing factors. It may affect eating behavior through the synthesis and receptor expression of digestive peptides and neurotransmitters.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Dejiang Xue, Miao Zhang, Qian Li, Hui Liu, Di Zhao, Guanghong Zhou, Chunbao Li
Summary: This study aimed to investigate the digestion of myoglobin diet in vitro and its relationship with gut microbiota and intestinal barrier. The in vitro study showed that myoglobin diets had a higher alpha-helix content and lower digestibility. The results from feeding C57BL/6J mice with different levels of myoglobin in the diet for 3 and 8 weeks revealed that increasing myoglobin content led to a significant increase in the relative abundance of Akkermansia muciniphila. Additionally, the content of short chain fatty acids exhibited a trend of increase and then decrease as myoglobin content increased at 3 weeks. A low-myoglobin diet upregulated the gene expression related to colonic mucin and tight junction proteins by increasing the proportion of beneficial microbiota, while a high-myoglobin diet had adverse effects.
