SOX9 and the many facets of its regulation in the chondrocyte lineage

Acetylation reduces SOX9 nuclear entryand ACANgene transactivation in human chondrocytes

(2016) Michal Bar Oz et al.   AGING CELL

Pioneer transcription factors, chromatin dynamics, and cell fate control

(2016) Kenneth S Zaret et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

The SOX9 upstream region prone to chromosomal aberrations causing campomelic dysplasia contains multiple cartilage enhancers

(2015) B. Yao et al.   NUCLEIC ACIDS RESEARCH

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis

(2015) Chia-Feng Liu et al.   NUCLEIC ACIDS RESEARCH

Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming

(2015) Wen-Li Mu et al.   STEM CELLS

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte

(2015) Shinsuke Ohba et al.   Cell Reports

Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage

(2015) J. Park et al.   Biology Open

Identification of Novel Craniofacial Regulatory Domains Located far Upstream ofSOX9and Disrupted in Pierre Robin Sequence

(2014) Christopher T. Gordon et al.   HUMAN MUTATION

Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells

(2014) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Epigenetic Regulation of SOX9 by miR-145 in Human Chondrosarcoma

(2014) Isabella W.Y. Mak et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters

(2014) Chun-do Oh et al.   PLoS One

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor Maintains Chondrogenic Potential of Limb Bud Mesenchymal Cells by Modulating DNMT3A Recruitment

(2014) Deepak Kumar et al.   Cell Reports

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Sox proteins: regulators of cell fate specification and differentiation

(2013) Y. Kamachi et al.   DEVELOPMENT

Towards elucidating the role of SirT1 in osteoarthritis

(2013) Mona Dvir-Ginzberg   Frontiers in Bioscience-Landmark

E6-AP/UBE3A Protein Acts as a Ubiquitin Ligase toward SOX9 Protein

(2013) Takako Hattori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tensile strain increases expression of CCN2 and COL2A1 by activating TGF-β-Smad2/3 pathway in chondrocytic cells

(2013) Takayuki Furumatsu et al.   JOURNAL OF BIOMECHANICS

A far-upstream (−70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration

(2013) Timothy J. Mead et al.   NUCLEIC ACIDS RESEARCH

Differentially Expressed MicroRNAs in Chondrocytes from Distinct Regions of Developing Human Cartilage

(2013) Audrey McAlinden et al.   PLoS One

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

The postnatal role of Sox9 in cartilage

(2012) Stephen P Henry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression ofSox9

(2012) Shan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest

(2012) Pei-Chih Lee et al.   JOURNAL OF CELL BIOLOGY

A misplaced lncRNA causes brachydactyly in humans

(2012) Philipp G. Maass et al.   JOURNAL OF CLINICAL INVESTIGATION

Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes

(2012) Linghui Dai et al.   ARTHRITIS RESEARCH & THERAPY

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

(2011) D. Ikegami et al.   DEVELOPMENT

Regulation of Human Chondrocyte Function through Direct Inhibition of Cartilage Master Regulator SOX9 by MicroRNA-145 (miRNA-145)

(2011) Aida Martinez-Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the transcriptional regulatory machinery in chondrogenesis

(2011) Haruhiko Akiyama et al.   JOURNAL OF BONE AND MINERAL METABOLISM

MicroRNA-145 Regulates Chondrogenic Differentiation of Mesenchymal Stem Cells by Targeting Sox9

(2011) Bo Yang et al.   PLoS One

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

(2011) Yukio Nakamura et al.   Nature Communications

SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression

(2011) Victor Y. L. Leung et al.   PLoS Genetics

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

(2010) T. Hattori et al.   DEVELOPMENT

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction

(2009) Walter Dunn et al.   ARTHRITIS AND RHEUMATISM

Rho kinase–dependent activation of SOX9 in chondrocytes

(2009) Dominik R. Haudenschild et al.   ARTHRITIS AND RHEUMATISM

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification

(2009) Tatsuo Ito et al.   BMC DEVELOPMENTAL BIOLOGY

The early history of the Sox genes

(2009) Robin Lovell-Badge   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The SoxD transcription factors – Sox5, Sox6, and Sox13 – are key cell fate modulators

(2009) Véronique Lefebvre   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acquisition of SOX transcription factor specificity through protein–protein interaction, modulation of Wnt signalling and post-translational modification

(2009) Pascal Bernard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Long-range regulation at the SOX9 locus in development and disease

(2009) C T Gordon et al.   JOURNAL OF MEDICAL GENETICS

The Transcriptional Activity of Sox9 in Chondrocytes Is Regulated by RhoA Signaling and Actin Polymerization

(2009) D. Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence

(2009) Sabina Benko et al.   NATURE GENETICS

Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells

(2009) M. Ushita et al.   OSTEOARTHRITIS AND CARTILAGE

Acetylation of Sox2 Induces its Nuclear Export in Embryonic Stem Cells

(2009) Gretchen A. Baltus et al.   STEM CELLS

Smad3 activates the Sox9-dependent transcription on chromatin

(2008) Takayuki Furumatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sox9 Inhibits Wnt Signaling by Promoting β-Catenin Phosphorylation in the Nucleus

(2008) Lilia Topol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5

(2008) Takako Hattori et al.   NUCLEIC ACIDS RESEARCH