Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells

Epithelial–mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways

(2016) D Fang et al.   ONCOGENE

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

(2016) X Xie et al.   ONCOGENE

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway

(2016) Daniela Massihnia et al.   Oncotarget

Prolactin/Jak2 directs apical/basal polarization and luminal linage maturation of mammary epithelial cells through regulation of the Erk1/2 pathway

(2015) Fengming Liu et al.   Stem Cell Research

Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

(2015) Murugan Kalimutho et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy

(2015) Mattheus C.B. Wielenga et al.   Cell Reports

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

(2013) Neil E. Bhola et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging targeted therapies in triple-negative breast cancer

(2012) J. Crown et al.   ANNALS OF ONCOLOGY

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

(2012) F. Chen   CANCER RESEARCH

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

(2012) Nagaraj et al.   Frontiers in Bioscience-Landmark

EGFR Kinase Promotes Acquisition of Stem Cell-Like Properties: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma Stem Cells

(2012) Eric L. Abhold et al.   PLoS One

A New Mouse Model for the Study of Human Breast Cancer Metastasis

(2012) Elizabeth Iorns et al.   PLoS One

A phase I study of dasatinib and weekly paclitaxel for metastatic breast cancer

(2011) M. N. Fornier et al.   ANNALS OF ONCOLOGY

Dasatinib as a Single Agent in Triple-Negative Breast Cancer: Results of an Open-Label Phase 2 Study

(2011) R. S. Finn et al.   CLINICAL CANCER RESEARCH

Phase II Trial of Dasatinib in Patients with Metastatic Breast Cancer Using Real-Time Pharmacodynamic Tissue Biomarkers of Src Inhibition to Escalate Dosing

(2011) Christina I. Herold et al.   CLINICAL CANCER RESEARCH

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

(2011) Siyuan Zhang et al.   NATURE MEDICINE

Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype

(2010) Junichi Kurebayashi et al.   BMC CANCER

Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo

(2010) Yi Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies

(2010) Manmeet S. Ahluwalia et al.   CANCER LETTERS

LYN Is a Mediator of Epithelial-Mesenchymal Transition and a Target of Dasatinib in Breast Cancer

(2010) Y.-L. Choi et al.   CANCER RESEARCH

Retinoid signaling regulates breast cancer stem cell differentiation

(2010) Christophe Ginestier et al.   CELL CYCLE

Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells

(2010) B. Campos et al.   CLINICAL CANCER RESEARCH

Advances in Targeting Src in the Treatment of Breast Cancer and Other Solid Malignancies

(2010) E. L. Mayer et al.   CLINICAL CANCER RESEARCH

Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

(2010) Ylenia Lombardo et al.   GASTROENTEROLOGY

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

The Role of Src in Solid Tumors

(2009) D. L. Wheeler et al.   ONCOLOGIST

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Triple-Negative Breast Cancer: Risk Factors to Potential Targets

(2008) B. P. Schneider et al.   CLINICAL CANCER RESEARCH

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute