Small Heat Shock Proteins in Cancers: Functions and Therapeutic Potential for Cancer Therapy

Structural and functional properties of proteins interacting with small heat shock proteins

(2020) Afrooz Dabbaghizadeh et al.   CELL STRESS & CHAPERONES

Peeking from behind the veil of enigma: emerging insights on small heat shock protein structure and function

(2020) Rachel E. Klevit   CELL STRESS & CHAPERONES

Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells

(2020) Asma Vafadar et al.   Cell and Bioscience

Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy

(2020) Alexander Kabakov et al.   Cells

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

(2020) Thomas L. Prince et al.   Cells

Membrane-Associated Heat Shock Proteins in Oncology: From Basic Research to New Theranostic Targets

(2020) Maxim Shevtsov et al.   Cells

Metabolic Adaptations in Cancer Stem Cells

(2020) Umesh Prasad Yadav et al.   Frontiers in Oncology

The IXth CSSI international symposium on heat shock proteins in biology and medicine: stress responses in health and disease

(2019) Stuart K. Calderwood et al.   CELL STRESS & CHAPERONES

Mechanisms of Small Heat Shock Proteins

(2019) Maria K. Janowska et al.   Cold Spring Harbor Perspectives in Biology

High metabolic rate and stem cell characteristics of esophageal cancer stem‐like cells depend on the Hsp27‐AKT‐HK2 pathway

(2019) Chen‐Chi Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Small heat shock proteins: multifaceted proteins with important implications for life

(2019) Serena Carra et al.   CELL STRESS & CHAPERONES

The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism

(2019) Marjorie Reyes-Farias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Randomized, Double‐Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX‐427) in Patients with Previously Untreated Stage IV Non‐Squamous‐Non‐Small‐Cell Lung Cancer: The SPRUCE Trial

(2019) David R. Spigel et al.   ONCOLOGIST

Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

(2019) Choi et al.   Cancers

Heat Shock Proteins and Ovarian Cancer: Important Roles and Therapeutic Opportunities

(2019) Abdullah Hoter et al.   Cancers

17β-Estradiol Activates HSF1 via MAPK Signaling in ERα-Positive Breast Cancer Cells

(2019) Natalia Vydra et al.   Cancers

Protein–Protein Interactions in the Molecular Chaperone Network

(2018) Rebecca Freilich et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent

(2018) Takahito Kawano et al.   BIOMATERIALS

Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion

(2018) Yusuke Yamamoto et al.   BRAIN RESEARCH

Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple negative breast cancer

(2018) Haifa Shen et al.   CLINICAL CANCER RESEARCH

Exploring the multifaceted roles of heat shock protein B8 (HSPB8) in diseases

(2018) Fazhao Li et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Alpha B-crystallin promotes the invasion and metastasis of gastric cancer via NF-κB-induced epithelial-mesenchymal transition

(2018) Dehu Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HSP27 associates with epithelial-mesenchymal transition, stemness and radioresistance of salivary adenoid cystic carcinoma

(2018) Wei Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protein Disaggregation in Multicellular Organisms

(2018) Nadinath B. Nillegoda et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)

(2018) Rong Wang et al.   MEDICAL SCIENCE MONITOR

Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway

(2018) Suat Erdogan et al.   BIOMEDICINE & PHARMACOTHERAPY

Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation

(2018) Hung-Hua Liang et al.   LIFE SCIENCES

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Small heat shock proteins: Simplicity meets complexity

(2018) Martin Haslbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the mammalian heat shock factor 1

(2017) Sharadha Dayalan Naidu et al.   FEBS Journal

High expression of heat shock proteins and heat shock factor-1 distinguishes an aggressive subset of clear cell renal cell carcinoma

(2017) Pao-Shu Wu et al.   HISTOPATHOLOGY

The small heat shock protein Hsp27: Present understanding and future prospects

(2017) Manish Kumar Singh et al.   JOURNAL OF THERMAL BIOLOGY

Tumor angiogenesis revisited: Regulators and clinical implications

(2017) Roberto Ronca et al.   MEDICINAL RESEARCH REVIEWS

Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF

(2017) John D. Konda et al.   Molecular Oncology

New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

(2017) Nuria Vilaboa et al.   NUCLEIC ACIDS RESEARCH

HspB5 correlates with poor prognosis in colorectal cancer and prompts epithelial-mesenchymal transition through ERK signaling

(2017) Qinghua Li et al.   PLoS One

Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator

(2017) Nikolai N. Sluchanko et al.   STRUCTURE

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells

(2017) Margherita Piccolella et al.   Oncotarget

Sensitization of lung cancer cells by altered dimerization of HSP27

(2017) Byeol Choi et al.   Oncotarget

Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27

(2017) Kazuyo Yasuda et al.   Oncotarget

Inactivation of p38 MAPK contributes to stem cell-like properties of non-small cell lung cancer

(2017) Yan Fang et al.   Oncotarget

A randomized phase II study of OGX-427 plus prednisone versus prednisone alone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer.

(2017) Kim N. Chi et al.   JOURNAL OF CLINICAL ONCOLOGY

Increased HSP27 correlates with malignant biological behavior of non-small cell lung cancer and predicts patient’s survival

(2017) Baowei Sheng et al.   Scientific Reports

A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers

(2016) K. N. Chi et al.   ANNALS OF ONCOLOGY

Functional state of the Hsp27 chaperone as a molecular marker of an unfavorable course of larynx cancer

(2016) Evgeniya V. Kaigorodova et al.   Cancer Biomarkers

The stress response paradox: fighting degeneration at the cost of cancer

(2016) Sonja L. B. Arneaud et al.   FEBS Journal

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Antioxidant Molecules and Heat Shock Protein 27 in Thyroid Tumors

(2016) Shanshan Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Advances in HSP27 and HSP90-targeting strategies for glioblastoma

(2016) Randy van Ommeren et al.   JOURNAL OF NEURO-ONCOLOGY

Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells

(2016) Andrei P. Drabovich et al.   MOLECULAR & CELLULAR PROTEOMICS

Effects of HSP27 downregulation on PDT resistance through PDT-induced autophagy in head and neck cancer cells

(2016) JISUN KIM et al.   ONCOLOGY REPORTS

Diagnostic Biomarkers in Oral Verrucous Carcinoma: A Systematic Review

(2016) Sepanta Hosseinpour et al.   PATHOLOGY & ONCOLOGY RESEARCH

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

(2016) Sophia Ungelenk et al.   Nature Communications

The small heat shock protein αA-crystallin negatively regulates pancreatic tumorigenesis

(2016) Jifang Liu et al.   Oncotarget

Sulforaphane-induced apoptosis involves the type 1 IP3 receptor

(2016) Sona Hudecova et al.   Oncotarget

High level of αB-crystallin contributes to the progression of osteosarcoma

(2016) Qing-Ming Shi et al.   Oncotarget

Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-β1/p38/HSP27 signaling in renal cell carcinoma

(2016) Yiyang Liu et al.   Oncotarget

The molecular and clinical verification of therapeutic resistance via the p38 MAPK–Hsp27 axis in lung cancer

(2016) Chia-Lin Liu et al.   Oncotarget

Ovatodiolide Inhibits Breast Cancer Stem/Progenitor Cells through SMURF2-Mediated Downregulation of Hsp27

(2016) Kuan-Ta Lu et al.   Toxins

Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-α-Induced Migration and Invasion of Hepatocellular Carcinoma Cells

(2016) Rie Matsushima-Nishiwaki et al.   PLoS One

Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration

(2015) Mariko Suzuki et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Mechanism of Subunit Recruitment in Human Small Heat Shock Protein Oligomers

(2015) Scott P. Delbecq et al.   BIOCHEMISTRY

Small heat shock proteins: Role in cellular functions and pathology

(2015) Raman Bakthisaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma

(2015) Marcela Gimenez et al.   BMC CANCER

Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes

(2015) N. V. Ryazantseva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer

(2015) Evgeniya V. Kaigorodova et al.   Cancer Biomarkers

Palytoxin Induces Dissociation of HSP 27 Oligomers through a p38 Protein Kinase Pathway

(2015) Chiara Berni et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells

(2015) Thanh Huong Nguyen Ho-Bouldoires et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hsp27 Inhibition with OGX-427 Sensitizes Non-Small Cell Lung Cancer Cells to Erlotinib and Chemotherapy

(2015) B. Lelj-Garolla et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells

(2015) XI CHEN et al.   Molecular Medicine Reports

Quercetin Mediates β-Catenin in Pancreatic Cancer Stem-Like Cells

(2015) Caineng Cao et al.   PANCREAS

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma

(2015) Nicole M.A. White et al.   Oncotarget

As a novel p53 direct target, bidirectional gene HspB2/αB-crystallin regulates the ROS level and Warburg effect

(2014) Shuang Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem/progenitor cells

(2014) Che-Hsin Lee et al.   BIOCHIMIE

Small heat-shock proteins: important players in regulating cellular proteostasis

(2014) Teresa M. Treweek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alpha-B-crystallin expression in human laryngeal squamous cell carcinoma tissues

(2014) Mehmet Yilmaz et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation

(2014) JIAYING LIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Heat shock protein 22 overexpression is associated with the progression and prognosis in gastric cancer

(2014) Xiao-shan Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Decreased Expression of Heat Shock Protein 20 in Colorectal Cancer and Its Implication in Tumorigenesis

(2014) Young-Tae Ju et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6

(2014) Stephen D. Weeks et al.   JOURNAL OF STRUCTURAL BIOLOGY

Elevated expression of CRYAB predicts unfavorable prognosis in non-small cell lung cancer

(2014) Hui Qin et al.   MEDICAL ONCOLOGY

Targeting heat shock proteins in metastatic castration-resistant prostate cancer

(2014) Arun A. Azad et al.   Nature Reviews Urology

 B-Crystallin: A Novel Regulator of Breast Cancer Metastasis to the Brain

(2013) D. Malin et al.   CLINICAL CANCER RESEARCH

Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3

(2013) Dominique Thuringer et al.   FASEB JOURNAL

Is Alpha-B Crystallin an Independent Marker for Prognosis in Lung Cancer?

(2013) Andrew J.M. Campbell-Lloyd et al.   Heart Lung and Circulation

HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor

(2013) Simona Pavan et al.   INTERNATIONAL JOURNAL OF CANCER

Methyl Antcinate A Suppresses the Population of Cancer Stem-Like Cells in MCF7 Human Breast Cancer Cell Line

(2013) Chih-Yu Peng et al.   MOLECULES

Peptide aptamers: tools to negatively or positively modulate HSPB1(27) function

(2013) B. Gibert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?

(2013) M. Zhao et al.   TUMOR BIOLOGY

Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells

(2012) Che-Hsin Lee et al.   BIOCHIMIE

Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis

(2012) Shih-Pei Lin et al.   CANCER LETTERS

αB-crystallin is a useful marker for triple negative and basal breast cancers

(2012) Julia Y S Tsang et al.   HISTOPATHOLOGY

Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma

(2012) Yuan Mao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer

(2012) M. Kumano et al.   MOLECULAR CANCER THERAPEUTICS

Survival of Cancer Stem Cells under Hypoxia and Serum Depletion via Decrease in PP2A Activity and Activation of p38-MAPKAPK2-Hsp27

(2012) Shih-Pei Lin et al.   PLoS One

Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer Cells

(2012) Su-Feng Chen et al.   PLoS One

Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer

(2012) O. Straume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

αB-Crystallin in clear cell renal cell carcinoma: Tumor progression and prognostic significance

(2012) Pei-Yin Ho et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Heat shock protein 27 and p16 immunohistochemistry in cervical intraepithelial neoplasia and squamous cell carcinoma

(2012) Akiko Tozawa-Ono et al.   Human Cell

Small Heat Shock Protein as a Multifunctional Scaffold: Integrated Tumor Targeting and Caspase Imaging within a Single Cage

(2011) Seung-Hye Choi et al.   BIOMACROMOLECULES

Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation

(2011) Cristina P. R. Xavier et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells

(2011) Davide Staedler et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment

(2011) Rieko Fujita et al.   CELL STRESS & CHAPERONES

RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients

(2011) Jörg-Christian Heinrich et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Activity of tumor necrosis factor-α blocked by phytoglycoprotein (38 kDa) at initiation stage in N-nitrosodiethylamine-induced ICR mice

(2011) Jin Lee et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibitory effect of SJSZ glycoprotein (38 kDa) on expression of heat shock protein 27 and 70 in chromium (VI)-treated hepatocytes

(2011) Jin Lee et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers

(2011) B Gibert et al.   ONCOGENE

Gene expression pattern in canine mammary osteosarcoma

(2011) K. Pawłowski et al.   POLISH JOURNAL OF VETERINARY SCIENCES

The small heat shock protein αA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis

(2010) Mi Deng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway

(2010) Shayna E. Oshita et al.   BREAST CANCER RESEARCH AND TREATMENT

Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27

(2010) Han-Shui Hsu et al.   CANCER

Serine 59 Phosphorylation of αB-Crystallin Down-regulates Its Anti-apoptotic Function by Binding and Sequestering Bcl-2 in Breast Cancer Cells

(2010) Nathalie Launay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing Heat Shock Protein 27 Decreases Metastatic Behavior of Human Head and Neck Squamous Cell Cancer Cells in Vitro

(2010) Zhenkun Zhu et al.   MOLECULAR PHARMACEUTICS

 B-crystallin regulation of angiogenesis by modulation of VEGF

(2009) S. Kase et al.   BLOOD

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

(2009) Qiaojia Huang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Expression profile of the small heat-shock protein alpha-B-crystallin in operated-on non-small-cell lung cancer patients: clinical implication☆☆☆

(2009) Radostina Cherneva et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Expression and prognostic significance of the αB-crystallin gene in human hepatocellular carcinoma

(2008) Qi Tang et al.   HUMAN PATHOLOGY

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

(2008) A. H. Stegh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA