Established and Emerging Mechanisms in the Pathogenesis of Arrhythmogenic Cardiomyopathy: A Multifaceted Disease
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Established and Emerging Mechanisms in the Pathogenesis of Arrhythmogenic Cardiomyopathy: A Multifaceted Disease
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 17, Pages 6320
Publisher
MDPI AG
Online
2020-08-31
DOI
10.3390/ijms21176320
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Emerging concepts in arrhythmogenic dilated cardiomyopathy
- (2020) Thomas Zegkos et al. HEART FAILURE REVIEWS
- Evidence From Family Studies for Autoimmunity in Arrhythmogenic Right Ventricular Cardiomyopathy
- (2020) Alida L.P. Caforio et al. CIRCULATION
- Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair
- (2020) Teresa Mancuso et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria
- (2020) Domenico Corrado et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy
- (2020) Tim R. Eijgenraam et al. Scientific Reports
- Mechanisms of intercellular Wnt transport
- (2019) Daniel Routledge et al. DEVELOPMENT
- Sudden death related cardiomyopathies – Arrhythmogenic right ventricular cardiomyopathy, arrhythmogenic cardiomyopathy, and exercise-induced cardiomyopathy
- (2019) Zackary D. Goff et al. PROGRESS IN CARDIOVASCULAR DISEASES
- Exosomes
- (2019) D. Michiel Pegtel et al. Annual Review of Biochemistry
- Disruption of Ca 2+ i Homeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice
- (2019) Joon-Chul Kim et al. CIRCULATION
- Current challenges in sudden cardiac death prevention
- (2019) Domenico Corrado et al. HEART FAILURE REVIEWS
- Single-cell imaging and transcriptomic analyses of endogenous cardiomyocyte dedifferentiation and cycling
- (2019) Yiqiang Zhang et al. Cell Discovery
- Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy
- (2019) Stephen P. Chelko et al. CIRCULATION
- Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress
- (2019) Chantal J.M. van Opbergen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β
- (2019) Laura Padrón-Barthe et al. CIRCULATION
- 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary
- (2019) Jeffrey A. Towbin et al. HEART RHYTHM
- Filamin C variants are associated with a distinctive clinical and immunohistochemical arrhythmogenic cardiomyopathy phenotype
- (2019) Charlotte L. Hall et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells
- (2019) Luca Puzzi et al. Cells
- Loss of cardiac Wnt/β-catenin signalling in desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention
- (2018) Alice Giuliodori et al. CARDIOVASCULAR RESEARCH
- Wnt signaling in development and tissue homeostasis
- (2018) Zachary Steinhart et al. DEVELOPMENT
- Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development
- (2018) Yang Xiao et al. DEVELOPMENTAL CELL
- An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis
- (2018) Diptendu Chatterjee et al. EUROPEAN HEART JOURNAL
- Stem cell-derived exosomes - an emerging tool for myocardial regeneration
- (2018) Erzsebet Lazar et al. World Journal of Stem Cells
- A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signaling and miRNA dysregulation
- (2018) Martina Calore et al. CARDIOVASCULAR RESEARCH
- Arrhythmic Genotypes in Familial Dilated Cardiomyopathy: Implications for Genetic Testing and Clinical Management
- (2018) Stacey Peters et al. Heart Lung and Circulation
- Prevalence and cardiac phenotype of patients with a phospholamban mutation
- (2018) I. E. Hof et al. Netherlands Heart Journal
- Use of flecainide in combination antiarrhythmic therapy in patients with arrhythmogenic right ventricular cardiomyopathy
- (2017) Simon Ermakov et al. HEART RHYTHM
- Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction
- (2017) Vimal Ramjee et al. JOURNAL OF CLINICAL INVESTIGATION
- Declining Risk of Sudden Death in Heart Failure
- (2017) Li Shen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective
- (2017) Matthias Rübsam et al. Cold Spring Harbor Perspectives in Biology
- Transforming growth factor β and its role in heart disease
- (2017) Guangwang Liu et al. Experimental and Therapeutic Medicine
- Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
- (2017) Marina Cerrone et al. Nature Communications
- Whole exome sequencing with genomic triangulation implicatesCDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy
- (2017) Kari L. Turkowski et al. Congenital Heart Disease
- Genotype-phenotype relationship in patients with arrhythmogenic right ventricular cardiomyopathy caused by desmosomal gene mutations: A systematic review and meta-analysis
- (2017) Zhenyan Xu et al. Scientific Reports
- Identification of Cadherin 2 ( CDH2 ) Mutations in Arrhythmogenic Right Ventricular CardiomyopathyCLINICAL PERSPECTIVE
- (2017) Bongani M. Mayosi et al. Circulation-Cardiovascular Genetics
- Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial InjuryClinical Perspective
- (2016) Lior Zangi et al. CIRCULATION
- Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology
- (2016) Conrad P. Hodgkinson et al. CIRCULATION RESEARCH
- Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In VitroNovelty and Significance
- (2016) Priyatansh Gurha et al. CIRCULATION RESEARCH
- Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin GeneNovelty and Significance
- (2016) Raffaella Lombardi et al. CIRCULATION RESEARCH
- Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies
- (2016) Martín F. Ortiz-Genga et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Characterization of Hippo Pathway Components by Gene Inactivation
- (2016) Steven W. Plouffe et al. MOLECULAR CELL
- Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure
- (2016) Lars Køber et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development
- (2016) Anamika Singh et al. Cell Reports
- Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
- (2015) Fa-Xing Yu et al. CELL
- Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family MembersCLINICAL PERSPECTIVE
- (2015) Judith A. Groeneweg et al. Circulation-Cardiovascular Genetics
- Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy
- (2015) E. Sommariva et al. EUROPEAN HEART JOURNAL
- Adipogenesis and epicardial adipose tissue: A novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation
- (2015) Yukiko Yamaguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family MembersCLINICAL PERSPECTIVE
- (2015) Judith A. Groeneweg et al. Circulation-Cardiovascular Genetics
- Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life‐Threatening Arrhythmias
- (2015) Anita Spezzacatene et al. Journal of the American Heart Association
- Arrhythmogenic Right Ventricular Cardiomyopathy With Recessive Inheritance Related to a New Homozygous Desmocollin-2 Mutation
- (2014) Basil Al-Sabeq et al. CANADIAN JOURNAL OF CARDIOLOGY
- Epicardium-to-fat transition in injured heart
- (2014) Qiaozhen Liu et al. CELL RESEARCH
- The Hippo signaling pathway in stem cell biology and cancer
- (2014) J.-S. Mo et al. EMBO REPORTS
- Prevalence and significance of rare RYR2 variants in arrhythmogenic right ventricular cardiomyopathy/dysplasia: Results of a systematic screening
- (2014) Nathalie Roux-Buisson et al. HEART RHYTHM
- Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy
- (2014) Francesca Brun et al. JOURNAL OF MEDICAL GENETICS
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
- (2014) H. Clevers et al. SCIENCE
- Re-Activated Adult Epicardial Progenitor Cells Are a Heterogeneous Population Molecularly Distinct from Their Embryonic Counterparts
- (2014) Sveva Bollini et al. STEM CELLS AND DEVELOPMENT
- Missense Mutations in Plakophilin-2 Cause Sodium Current Deficit and Associate With a Brugada Syndrome Phenotype
- (2013) Marina Cerrone et al. CIRCULATION
- The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy
- (2013) Suet Nee Chen et al. CIRCULATION RESEARCH
- Identification of a PKP2 gene deletion in a family with arrhythmogenic right ventricular cardiomyopathy
- (2013) Ilena Egle Astrid Li Mura et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model
- (2013) Robert C. Lyon et al. HUMAN MOLECULAR GENETICS
- Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
- (2013) Changsung Kim et al. NATURE
- Signaling by the TGF Superfamily
- (2013) J. L. Wrana Cold Spring Harbor Perspectives in Biology
- Recurrent and founder mutations in the Netherlands—Phospholamban p.Arg14del mutation causes arrhythmogenic cardiomyopathy
- (2013) P. A. van der Zwaag et al. Netherlands Heart Journal
- The phospholamban p.Arg14del founder mutation in Dutch patients with arrhythmogenic cardiomyopathy
- (2013) J. F. van der Heijden et al. Netherlands Heart Journal
- Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes
- (2012) Stefania Rizzo et al. CARDIOVASCULAR RESEARCH
- Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy
- (2012) Jolanda van Hengel et al. EUROPEAN HEART JOURNAL
- Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy
- (2012) Paul A. van der Zwaag et al. EUROPEAN JOURNAL OF HEART FAILURE
- Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy
- (2012) Maartje Noorman et al. HEART RHYTHM
- Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling
- (2012) B. T. MacDonald et al. Cold Spring Harbor Perspectives in Biology
- Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts
- (2011) Stephanie A. Matthes et al. CELL COMMUNICATION AND ADHESION
- Genetic Variation in Titin in Arrhythmogenic Right Ventricular Cardiomyopathy–Overlap Syndromes
- (2011) Matthew Taylor et al. CIRCULATION
- Nuclear Plakoglobin Is Essential for Differentiation of Cardiac Progenitor Cells to Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy
- (2011) Raffaella Lombardi et al. CIRCULATION RESEARCH
- Prognostic predictors in arrhythmogenic right ventricular cardiomyopathy: results from a 10-year registry
- (2011) B. Pinamonti et al. EUROPEAN HEART JOURNAL
- Mutations in the Lamin A/C gene mimic arrhythmogenic right ventricular cardiomyopathy
- (2011) Giovanni Quarta et al. EUROPEAN HEART JOURNAL
- Clinical phenotype and diagnosis of arrhythmogenic right ventricular cardiomyopathy in pediatric patients carrying desmosomal gene mutations
- (2011) Barbara Bauce et al. HEART RHYTHM
- Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy
- (2011) Deqiang Li et al. HUMAN MOLECULAR GENETICS
- Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle
- (2011) A. Uezumi et al. JOURNAL OF CELL SCIENCE
- Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
- (2011) Bin Zhou et al. JOURNAL OF CLINICAL INVESTIGATION
- Cardiac Tissue-Restricted Deletion of Plakoglobin Results in Progressive Cardiomyopathy and Activation of -Catenin Signaling
- (2011) J. Li et al. MOLECULAR AND CELLULAR BIOLOGY
- De novo cardiomyocytes from within the activated adult heart after injury
- (2011) Nicola Smart et al. NATURE
- Pathophysiology of arrhythmogenic cardiomyopathy
- (2011) Cristina Basso et al. Nature Reviews Cardiology
- IL-1β induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells
- (2010) Gaurav Verma et al. APOPTOSIS
- The Cardiac Desmosome and Arrhythmogenic Cardiomyopathies
- (2010) Mario Delmar et al. CIRCULATION RESEARCH
- Arrhythmogenic right ventricular cardiomyopathy is a disease of cardiac stem cells
- (2010) Raffaella Lombardi et al. CURRENT OPINION IN CARDIOLOGY
- Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice
- (2010) Veronique Fressart et al. EUROPACE
- Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: Proposed Modification of the Task Force Criteria
- (2010) F. I. Marcus et al. EUROPEAN HEART JOURNAL
- Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia
- (2010) Maria E. Campian et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Novel missense mutations in exon 15 of desmoglein-2: Role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?
- (2010) Katja Gehmlich et al. HEART RHYTHM
- De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy
- (2010) Baerbel Klauke et al. HUMAN MOLECULAR GENETICS
- Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
- (2010) Akiyoshi Uezumi et al. NATURE CELL BIOLOGY
- Cell-Cell Connection to Cardiac Disease
- (2010) Farah Sheikh et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Wnt signal transduction pathways
- (2010) Yuko Komiya et al. Organogenesis
- Genetic Fate Mapping Identifies Second Heart Field Progenitor Cells As a Source of Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy
- (2009) Raffaella Lombardi et al. CIRCULATION RESEARCH
- Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes
- (2009) Priscila Y. Sato et al. CIRCULATION RESEARCH
- Comprehensive Desmosome Mutation Analysis in North Americans With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
- (2009) A. Dénise den Haan et al. Circulation-Cardiovascular Genetics
- Plakophilins: multifunctional scaffolds for adhesion and signaling
- (2009) Amanda E Bass-Zubek et al. CURRENT OPINION IN CELL BIOLOGY
- Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
- (2009) Bryan T. MacDonald et al. DEVELOPMENTAL CELL
- Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene
- (2009) J. Peter van Tintelen et al. HEART RHYTHM
- The tale of transforming growth factor-beta (TGFβ) signaling: A soigné enigma
- (2009) Arindam Chaudhury et al. IUBMB LIFE
- Myocyte necrosis underlies progressive myocardial dystrophy in mousedsg2-related arrhythmogenic right ventricular cardiomyopathy
- (2009) Kalliopi Pilichou et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Is a Fully Penetrant, Lethal Arrhythmic Disorder Caused by a Missense Mutation in the TMEM43 Gene
- (2008) Nancy D. Merner et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Markedly increased intracellular lipid droplets and disruption of intercellular junctions in biopsied myocardium from a patient with arrhythmogenic right ventricular cardiomyopathy
- (2008) Shuichi Fujita et al. HEART AND VESSELS
- Left-Dominant Arrhythmogenic Cardiomyopathy
- (2008) Srijita Sen-Chowdhry et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
- (2008) Yu-Hua Tseng et al. NATURE
- Structural and Dynamic Basis of Phospholamban and Sarcolipin Inhibition of Ca2+-ATPase†
- (2007) Nathaniel J. Traaseth et al. BIOCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started