Therapeutic Potential of Cathelicidin Peptide LL-37, an Antimicrobial Agent, in a Murine Sepsis Model

Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils

(2020) Yumi Kumagai et al.   Innate Immunity

Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis

(2018) Hazem M.S. Lashin et al.   SHOCK

Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory response in a mouse septic model

(2017) Hiroshi Hosoda et al.   Molecular Medicine Reports

Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice

(2016) Zhongshuang Hu et al.   INTERNATIONAL IMMUNOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps

(2014) Ariane Neumann et al.   BIOCHEMICAL JOURNAL

Artesunate Reduces Serum Lipopolysaccharide in Cecal Ligation/Puncture Mice via Enhanced LPS Internalization by Macrophages through Increased mRNA Expression of Scavenger Receptors

(2014) Bin Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism

(2014) Zhongshuang Hu et al.   PLoS One

Plasma ATP is Required for Neutrophil Activation in a Mouse Sepsis Model

(2014) Yuka Sumi et al.   SHOCK

Neutrophil Extracellular Traps in Sepsis

(2014) Gabriela Camicia et al.   SHOCK

Extracellular ATP drives systemic inflammation, tissue damage and mortality

(2014) A Cauwels et al.   Cell Death & Disease

Pyroptotic death storms and cytopenia

(2013) Ben A Croker et al.   CURRENT OPINION IN IMMUNOLOGY

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

(2013) Jesmond Dalli et al.   EMBO Molecular Medicine

Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome

(2013) Yang Xiang et al.   PLoS One

Antibacterial effect of microvesicles released from human neutrophilic granulocytes

(2012) C. I. Timar et al.   BLOOD

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells

(2011) Kaori Suzuki et al.   INTERNATIONAL IMMUNOLOGY

The Search for Effective Therapy for Sepsis

(2011) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection

(2009) Fabiano Pinheiro da Silva et al.   APOPTOSIS

Multifunctional Antimicrobial Proteins and Peptides: Natural Activators of Immune Systems

(2009) Francois Niyonsaba et al.   CURRENT PHARMACEUTICAL DESIGN

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Molecular biology of inflammation and sepsis: A primer*

(2008) Ismail Cinel et al.   CRITICAL CARE MEDICINE