Plant P450s as versatile drivers for evolution of species-specific chemical diversity

Origins of P450 diversity

(2013) H. Sezutsu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

β-Amyrin Oxidation by Oat CYP51H10 Expressed Heterologously in Yeast Cells: The First Example of CYP51-Dependent Metabolism Other than the 14-Demethylation of Sterol Precursors

(2012) Mieko Kunii et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phylogenomics of the benzoxazinoid biosynthetic pathway of Poaceae: gene duplications and origin of the Bx cluster

(2012) Leslie Dutartre et al.   BMC EVOLUTIONARY BIOLOGY

Making new molecules – evolution of pathways for novel metabolites in plants

(2012) Daniel J Kliebenstein et al.   CURRENT OPINION IN PLANT BIOLOGY

Characterization of CYP76M5–8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster

(2012) Qiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of rhodiocyanosides in Lotus japonicus: Rhodiocyanoside A is synthesized from (Z)-2-methylbutanaloxime via 2-methyl-2-butenenitrile

(2012) Shigeki Saito et al.   PHYTOCHEMISTRY

Cytochrome P450 CYP716A53v2 Catalyzes the Formation of Protopanaxatriol from Protopanaxadiol During Ginsenoside Biosynthesis in Panax Ginseng

(2012) Jung-Yeon Han et al.   PLANT AND CELL PHYSIOLOGY

Comparative Analysis of Benzoxazinoid Biosynthesis in Monocots and Dicots: Independent Recruitment of Stabilization and Activation Functions

(2012) R. Dick et al.   PLANT CELL

CYP701A8: A Rice ent-Kaurene Oxidase Paralog Diverted to More Specialized Diterpenoid Metabolism

(2012) Q. Wang et al.   PLANT PHYSIOLOGY

Why biosynthetic genes for chemical defense compounds cluster

(2012) Adam M. Takos et al.   TRENDS IN PLANT SCIENCE

Bioactivities of Glycoalkaloids and Their Aglycones from Solanum Species

(2011) Sinead Eileen Milner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lettuce Costunolide Synthase (CYP71BL2) and Its Homolog (CYP71BL1) from Sunflower Catalyze Distinct Regio- and Stereoselective Hydroxylations in Sesquiterpene Lactone Metabolism

(2011) Nobuhiro Ikezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Primary Diterpene Synthase Products ofPicea abiesLevopimaradiene/Abietadiene Synthase (PaLAS) Are Epimers of a Thermally Unstable Diterpenol

(2011) Christopher I. Keeling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigation of the potential for triterpene synthesis in rice through genome mining and metabolic engineering

(2011) Yoshi-Shige Inagaki et al.   NEW PHYTOLOGIST

The Cyt P450 Enzyme CYP716A47 Catalyzes the Formation of Protopanaxadiol from Dammarenediol-II During Ginsenoside Biosynthesis in Panax ginseng

(2011) Jung-Yeon Han et al.   PLANT AND CELL PHYSIOLOGY

CYP716A Subfamily Members are Multifunctional Oxidases in Triterpenoid Biosynthesis

(2011) Ery O. Fukushima et al.   PLANT AND CELL PHYSIOLOGY

Metabolic Engineering inNicotiana benthamianaReveals Key Enzyme Functions inArabidopsisIndole Glucosinolate Modification

(2011) Marina Pfalz et al.   PLANT CELL

Medicago truncatulaCYP716A12 Is a Multifunctional Oxidase Involved in the Biosynthesis of Hemolytic Saponins

(2011) Maria Carelli et al.   PLANT CELL

Journey through the past: 150 million years of plant genome evolution

(2011) Sebastian Proost et al.   PLANT JOURNAL

Rice CYP734As function as multisubstrate and multifunctional enzymes in brassinosteroid catabolism

(2011) Tomoaki Sakamoto et al.   PLANT JOURNAL

Genomic clustering of cyanogenic glucoside biosynthetic genes aids their identification inLotus japonicusand suggests the repeated evolution of this chemical defence pathway

(2011) Adam M. Takos et al.   PLANT JOURNAL

A P450-centric view of plant evolution

(2011) David Nelson et al.   PLANT JOURNAL

The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom

(2011) Feng Chen et al.   PLANT JOURNAL

Evolution of Diterpene Metabolism: Sitka Spruce CYP720B4 Catalyzes Multiple Oxidations in Resin Acid Biosynthesis of Conifer Defense against Insects

(2011) B. Hamberger et al.   PLANT PHYSIOLOGY

Unusual P450 reactions in plant secondary metabolism

(2010) Masaharu Mizutani et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

P450s in plant–insect interactions

(2010) Mary A. Schuler   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Arthropod CYPomes illustrate the tempo and mode in P450 evolution

(2010) R. Feyereisen   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Biochemical Conservation and Evolution of Germacrene A Oxidase in Asteraceae

(2010) Don Trinh Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Terpenoid Biosynthesis and Specialized Vascular Cells of Conifer Defense

(2010) Katherine G. Zulak et al.   Journal of Integrative Plant Biology

Two rings in them all: The labdane-related diterpenoids

(2010) Reuben J. Peters   NATURAL PRODUCT REPORTS

Flavone synthase II (CYP93B16) from soybean (Glycine max L.)

(2010) Judith Fliegmann et al.   PHYTOCHEMISTRY

Arabidopsis CYP72C1 is an atypical cytochrome P450 that inactivates brassinosteroids

(2010) Leeann E. Thornton et al.   PLANT MOLECULAR BIOLOGY

CYP93G2 Is a Flavanone 2-Hydroxylase Required for C -Glycosylflavone Biosynthesis in Rice

(2010) Yegang Du et al.   PLANT PHYSIOLOGY

Dynamic Metabolons

(2010) B. L. Moller   SCIENCE

Plant Cytochrome CYP74 Family: Biochemical Features, Endocellular Localisation, Activation Mechanism in Plant Defence and Improvements for Industrial Applications

(2009) Richard K. Hughes et al.   CHEMBIOCHEM

Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum

(2009) Yegang Du et al.   JOURNAL OF EXPERIMENTAL BOTANY

A web-based resource for the Arabidopsis P450, cytochromes b5, NADPH-cytochrome P450 reductases, and family 1 glycosyltransferases (http://www.P450.kvl.dk)

(2009) Suzanne M. Paquette et al.   PHYTOCHEMISTRY

Benzoxazinoid biosynthesis, a model for evolution of secondary metabolic pathways in plants

(2009) Monika Frey et al.   PHYTOCHEMISTRY

CYP76M7 Is an ent-Cassadiene C11 -Hydroxylase Defining a Second Multifunctional Diterpenoid Biosynthetic Gene Cluster in Rice

(2009) S. Swaminathan et al.   PLANT CELL

CYP710A genes encoding sterol C22-desaturase in Physcomitrella patens as molecular evidence for the evolutionary conservation of a sterol biosynthetic pathway in plants

(2009) Tomomi Morikawa et al.   PLANTA

Evolution of a Novel Phenolic Pathway for Pollen Development

(2009) M. Matsuno et al.   SCIENCE

Hydroxynitrile glucosides

(2008) Nanna Bjarnholt et al.   PHYTOCHEMISTRY

Benzoxazinoid biosynthesis in dicot plants

(2008) Katrin Schullehner et al.   PHYTOCHEMISTRY

cDNA cloning and functional characterisation of CYP98A14 and NADPH:cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis

(2008) David Eberle et al.   PLANT MOLECULAR BIOLOGY

Functional plasticity of paralogous diterpene synthases involved in conifer defense

(2008) C. I. Keeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Licorice  -amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin

(2008) H. Seki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA