Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions

Intraductal Papillary Mucinous Neoplasms Arise from Multiple Independent Clones, Each With Distinct Mutations

(2019) Catherine G. Fischer et al.   GASTROENTEROLOGY

Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells

(2019) Louis Collet et al.   GUT

A multimodality test to guide the management of patients with a pancreatic cyst

(2019) Simeon Springer et al.   Science Translational Medicine

CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers

(2019) Collin Tokheim et al.   Cell Systems

Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines

(2019) Nadine C. M. van Huijgevoort et al.   Nature Reviews Gastroenterology & Hepatology

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

(2018) Jeanne Tie et al.   GUT

IPMNs with co-occurring invasive cancers: neighbours but not always relatives

(2018) Matthäus Felsenstein et al.   GUT

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features

(2018) Yuko Omori et al.   GASTROENTEROLOGY

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

(2018) Yuko Kuboki et al.   JOURNAL OF PATHOLOGY

Krüppel-like factor 4 (KLF4): What we currently know

(2017) Amr M. Ghaleb et al.   GENE

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

(2017) Waki Hosoda et al.   JOURNAL OF PATHOLOGY

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

(2017) Alvin P Makohon-Moore et al.   NATURE GENETICS

Pancreatic cysts: Diagnostic accuracy and risk of inappropriate resections

(2017) N. de Pretis et al.   PANCREATOLOGY

Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas

(2017) Masao Tanaka et al.   PANCREATOLOGY

Reconstructing metastatic seeding patterns of human cancers

(2017) Johannes G. Reiter et al.   Nature Communications

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis

(2016) Daoyan Wei et al.   CANCER CELL

Association Between Advances in High-Resolution Cross-Section Imaging Technologies and Increase in Prevalence of Pancreatic Cysts From 2005 to 2014

(2016) Maria Moris et al.   Clinical Gastroenterology and Hepatology

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

(2016) Kevin B Myant et al.   EMBO Molecular Medicine

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

(2016) Jun Yu et al.   GUT

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

(2015) Olca Basturk et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

(2015) Simeon Springer et al.   GASTROENTEROLOGY

American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

(2015) Santhi Swaroop Vege et al.   GASTROENTEROLOGY

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Comparison of Preoperative Conference-Based Diagnosis with Histology of Cystic Tumors of the Pancreas

(2014) Marco Del Chiaro et al.   ANNALS OF SURGICAL ONCOLOGY

Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization

(2014) H. Do et al.   CLINICAL CHEMISTRY

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

(2014) Eliana Amato et al.   JOURNAL OF PATHOLOGY

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

(2013) David E. Reuss et al.   ACTA NEUROPATHOLOGICA

Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor

(2013) Stephen J. Murphy et al.   GASTROENTEROLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

Somatic SETBP1 mutations in myeloid malignancies

(2013) Hideki Makishima et al.   NATURE GENETICS

Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8)

(2013) Neha Tiwari et al.   PLoS One

Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO

(2013) V. E. Clark et al.   SCIENCE

Complications after pancreatic resection: Diagnosis, prevention and management

(2013) Emilie Lermite et al.   Clinics and Research in Hepatology and Gastroenterology

Recurrent SETBP1 mutations in atypical chronic myeloid leukemia

(2012) Rocco Piazza et al.   NATURE GENETICS

851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusetts General Hospital

(2012) Nakul P. Valsangkar et al.   SURGERY

KLF4 is a Novel Candidate Tumor Suppressor Gene in Pancreatic Ductal Carcinoma

(2011) Francesca Zammarchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Detection and quantification of rare mutations with massively parallel sequencing

(2011) I. Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

(2011) J. Wu et al.   Science Translational Medicine

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas

(2011) Toru Furukawa et al.   Scientific Reports

F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor

(2010) Rocio Sancho et al.   GASTROENTEROLOGY

Prevalence of Unsuspected Pancreatic Cysts on MDCT

(2008) Thomas A. Laffan et al.   AMERICAN JOURNAL OF ROENTGENOLOGY