Article
Cell Biology
Xiaoying Fan, Ping Lu, Hongwei Wang, Shuhui Bian, Xinglong Wu, Yu Zhang, Yang Liu, Danqi Fu, Lu Wen, Jihui Hao, Fuchou Tang
Summary: This study used single-cell multiomics sequencing to uncover the epigenomic abnormality of pancreatic ductal adenocarcinoma (PDAC). The findings revealed differential DNA methylation and chromatin accessibility in cancer cells compared to normal epithelial cells, and identified novel candidate biomarkers associated with prognosis in PDAC patients.
Article
Biochemistry & Molecular Biology
Mina Noura, Hidemasa Matsuo, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa
Summary: TAL1 is frequently dysregulated in T-ALL, and its overexpression is associated with unfavorable clinical outcomes. This study found that the tumor suppressor KLF4 can suppress SE-driven TAL1 expression in T-ALL cells by inhibiting the formation of 5' TAL1 super-enhancer. A small molecule inducer of KLF4, APTO-253, exerts an anti-leukemic effect by targeting SE-driven TAL1 expression in T-ALL cells. Induction of KLF4 may be a promising strategy to control TAL1 expression and could serve as a novel treatment for T-ALL patients with poor prognosis.
Article
Oncology
Paul Najm, Peihua Zhao, Mikhail Steklov, Raj Nayan Sewduth, Maria Francesca Baietti, Silvia Pandolfi, Nathan Criem, Benoit Lechat, Teresa Mendes Maia, Delphi Van Haver, Nikky Corthout, Sven Eyckerman, Francis Impens, Anna A. Sablina
Summary: The study unveils the collaborative mechanism between TRAF7 and KLF4 in meningioma development, laying the groundwork for the development of new therapeutic strategies.
Article
Multidisciplinary Sciences
Yuanxin Tang, Sheng Zhang, Jiazi Li, Chunli Wu, Qing Fan
Summary: Pancreatic Ductal Adenocarcinoma (PDAC) is a deadly disease with increasing death rates and no effective treatment. The study suggests that ID1 is a critical determinant of PDAC development and progression, serving as a potential malignant biomarker for the disease.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Chao Dai, Jonathan P. Rennhack, Taylor E. Arnoff, Maneesha Thaker, Scott T. Younger, John G. Doench, August Yue Huang, Annan Yang, Andrew J. Aguirre, Belinda Wang, Evan Mun, Joyce T. O'Connell, Ying Huang, Katherine Labella, Jessica A. Talamas, Ji Li, Nina Ilic, Justin Hwang, Andrew L. Hong, Andrew O. Giacomelli, Ole Gjoerup, David E. Root, William C. Hahn
Summary: Metastasis is a complex and poorly understood process, especially in pancreatic cancer where loss of SMAD4 is correlated with metastatic disease and poor prognosis. This study identified FOSL1 as a SMAD4 target that plays a critical role in driving colonization to the lung, suggesting that early targeting of these genes may provide therapeutic benefits.
Article
Oncology
Sen Yang, Yalu Zhang, Yuze Hua, Ming Cui, Mengyi Wang, Junyi Gao, Qiaofei Liu, Quan Liao
Summary: GREM1 is overexpressed in PDAC and is associated with tumor stroma formation and immunosuppression. Serum GREM1 levels are also elevated and can serve as diagnostic markers and prognostic factors for PDAC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Colin F. Davenport, Tobias Scheithauer, Alessia Dunst, Frauke Sophie Bahr, Marie Dorda, Lutz Wiehlmann, Doan Duy Hai Tran
Summary: Downregulation of multiple tumor suppressor genes is crucial in cancer formation, with epigenetic modifications playing a significant role. Using nanopore sequencing technology, the study identified potential TSGs in HCC and demonstrated the tumor suppressor function of GCK in inhibiting HCC cell proliferation through lactate accumulation-induced energy crisis. These findings offer valuable insights for further understanding tumorigenesis in human cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Article
Biochemistry & Molecular Biology
Yang Li, Min Liu, Shuting Yang, Ashley M. Fuller, T. S. Karin Eisinger-Mathason, Shuying Yang
Summary: This study identifies RGS12 as a novel tumor suppressor in osteosarcoma through inhibiting the YAP-TEAD1-Ezrin signaling pathway and provides evidence that targeting RGS12 may be a therapeutic strategy for osteosarcoma.
Article
Oncology
Weiyang Cai, Wenming Bao, Shengwei Chen, Yan Yang, Yanyan Li
Summary: This study investigated the correlation between metabolism and immunity in the progression of pancreatic cancer through retrospective analysis and bioinformatics approaches. It revealed the importance of metabolism-related genes in evaluating the prognosis of PDAC patients and highlighted the key role of immune-related signaling pathways in tumor development.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Zhihua Ye, Yingyu Yang, Ying Wei, Lamei Li, Xinyi Wang, Junkai Zhang
Summary: This study identified PCDH1 as a new prognostic marker in pancreatic ductal adenocarcinoma (PDAC) patients. PCDH1 expression was upregulated in PDAC tissues and was associated with tumor invasion depth and lymph node metastasis. Mechanistically, PCDH1 enhanced p65 nuclear localization by interacting with KPNB1, activating the NF-kappa B signaling pathway and promoting PDAC progression.
CELL DEATH & DISEASE
(2022)
Editorial Material
Oncology
Samuel J. S. Rubin, Raoul S. Sojwal, John Gubatan, Stephan Rogalla
Summary: This review discusses the pro- and anticancer immune responses in the tumor immune microenvironment of pancreatic ductal adenocarcinoma (PDAC) and explores their potential for the development of novel therapeutic approaches.
Review
Biochemistry & Molecular Biology
Yuanyuan Wei, Ahmad Taha Khalaf, Cao Rui, Samiah Yasmin Abdul Kadir, Jamaludin Zainol, Zahraa Oglah
Summary: Integral membrane proteins, called TRP channels, act as cellular sensors in various systems, and their sequence similarity classifies them into nine subfamilies, providing a wide range of physiological functions. Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer. Despite the difficulty in studying human tissue samples, recent research has made progress in understanding the molecular mechanisms of TRP channel disturbance. This review summarizes the current understanding of TRP channels' role in the development and progression of pancreatic ductal carcinoma, aiming to identify potential therapeutic interventions.
Article
Oncology
Sophia G. Kisling, Pranita Atri, Ashu Shah, Jesse L. Cox, Sunandini Sharma, Lynette M. Smith, Dario Ghersi, Surinder K. Batra
Summary: By analyzing the transcriptomic profiles, we identified gene signals associated with short-term and long-term survival in patients with pancreatic ductal adenocarcinoma (PDAC). These gene signals are regulated by a master regulator gene, HOXA10. These findings may contribute to improving the prognosis of PDAC patients and revealing the molecular interactions involved.
CLINICAL CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Changpeng Cui, Qingji Huo, Xue Xiong, Kexin Li, Melissa L. Fishel, Baiyan Li, Hiroki Yokota
Summary: This research identified an anticancer peptide P04 derived from aldolase A (ALDOA) which showed efficient anti-PDAC activities. P04 interacted with epidermal growth factor receptor (EGFR) and downregulated oncoproteins such as Snail and Src. Furthermore, P04 had no inhibitory effect on mesenchymal stem cells (MSCs). The study also demonstrated the potential of converting peripheral blood mononuclear cells (PBMCs) into induced tumor-suppressing cells (iTSCs) through mechanical vibration.
Article
Oncology
Gennaro Nappo, Domenico Borzomati, Alessandro Zerbi, Paola Spaggiari, Ugo Boggi, Daniela Campani, Slawomir Mrowiec, Lukasz Liszka, Alessandro Coppola, Michela Amato, Tommasangelo Petitti, Fabio Vistoli, Marco Montorsi, Giuseppe Perrone, Roberto Coppola, Damiano Caputo
Summary: There is no clear evidence on the most effective method of pathological analysis and clearance definition for defining R1 resection after PD. The 1 mm clearance is the most effective factor in determining the R1 rate after PD, but the pathological method is crucial in accurately evaluating its prognostic role.
Article
Oncology
Laura Crocetti, Paola Scalise, Elena Bozzi, Daniela Campani, Piercarlo Rossi, Rosa Cervelli, Irene Bargellini, Davide Ghinolfi, Paolo De Simone, Roberto Cioni
Summary: This study aimed to evaluate the efficacy of Microwave (MW) ablation by correlating with histology in excised liver samples at the time of liver transplantation. The results showed a high rate of complete necrosis with MW ablation for hepatocellular carcinoma nodules, indicating its effectiveness in percutaneous treatment.
Article
Medicine, General & Internal
Rossella Bruno, Elisa Sensi, Cristiana Lupi, Mirella Giordano, Laura Bernardini, Caterina Vivaldi, Lorenzo Fornaro, Enrico Vasile, Daniela Campani, Gabriella Fontanini
Summary: PDAC is an aggressive cancer often diagnosed in advanced stages with limited treatment options. Olaparib, a PARP inhibitor, is approved for maintenance therapy in PDAC patients with BRCA1/2 mutations. Testing for BRCA1/2 mutations in pancreatic tumor tissues is feasible on small biopsies.
Article
Oncology
Francesca Zammarchi, Karin E. G. Havenith, Simon Chivers, Paul Hogg, Francois Bertelli, Peter Tyrer, Narinder Janghra, Halla W. Reinert, John A. Hartley, Patrick H. van Berkel
Summary: ADCT-601 is an antibody-drug conjugate that targets AXL and effectively kills cancer cells by releasing cytotoxin. In preclinical studies, ADCT-601 showed potent antitumor activity and outperformed other drugs in certain situations. It also demonstrated good tolerability and stability.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Maria Angela Guzzardi, Federica La Rosa, Daniela Campani, Andrea Cacciato Insilla, Vincenzo De Sena, Daniele Panetta, Maurizia Rossana Brunetto, Ferruccio Bonino, Maria Carmen Collado, Patricia Iozzo
Summary: Metabolic-associated fatty liver disease is a major chronic condition, with maternal obesity as a common risk factor. Studies have shown that a maternal high-fat diet can exacerbate the weaning reaction, leading to abnormal liver metabolism and increased susceptibility to steatohepatitis in adulthood, while gut microbiota composition and metabolic pathways after weaning also play a role in the risk of fatty liver disease later in life.
Article
Biochemistry & Molecular Biology
Sara Franceschi, Francesca Lessi, Mariangela Morelli, Michele Menicagli, Francesco Pasqualetti, Paolo Aretini, Chiara Maria Mazzanti
Summary: This study highlights the importance of SHPK in glioblastoma for tumor progression, and proposes this enzyme and the nonoxidative pentose phosphate pathway as possible therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Angela Guzzardi, Federica La Rosa, Daniela Campani, Andrea Cacciato Insilla, Monica Nannipieri, Maurizia Rossana Brunetto, Ferruccio Bonino, Patricia Iozzo
Summary: This study validated the use of PET with oral FDG administration in mice to examine the role of the gastrointestinal tract in glucose metabolism. The results showed that the GI tract can selectively suppress glucose metabolism in organs responsible for energy intake and storage, and this effect is blunted by lipid ingestion. Furthermore, modulation of gut and liver inflammation may be involved in the acute signaling of the energy status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Francesca Lessi, Sara Franceschi, Mariangela Morelli, Michele Menicagli, Francesco Pasqualetti, Orazio Santonocito, Carlo Gambacciani, Francesco Pieri, Filippo Aquila, Paolo Aretini, Chiara Maria Mazzanti
Summary: This study used fluorescent labeling and cell separation techniques to analyze glioblastoma at the single-cell level, revealing the genetic characteristics of different components within the tumor. This single-cell approach provides new insights into the understanding of glioblastoma.
Article
Biochemistry & Molecular Biology
Maria Angela Guzzardi, Federica La Rosa, Daniela Campani, Maria Carmen Collado, Daniel Monleon, Andrea Cacciato Insilla, Maria Tripodi, Alessandro Zega, Alessia Dattilo, Maurizia Rossana Brunetto, Margherita Maffei, Ferruccio Bonino, Patricia Iozzo
Summary: Metabolic impairments and alterations in liver and adipose depots were observed in subjects with Alzheimer's disease (AD), and the gut microbiota may play a modulating role. In a mouse model of AD, we investigated the changes in liver and white/brown adipose tissues and their associations with serum and gut metabolites and gut bacteria. The findings showed impaired lipid accumulation in liver and adipose tissues, along with disrupted gut microbiota profiles.
Article
Endocrinology & Metabolism
Lars Krogvold, Angelo Genoni, Anna Puggioni, Daniela Campani, Sarah J. Richardson, Christine S. Flaxman, Bjorn Edwin, Trond Buanes, Knut Dahl-Jorgensen, Antonio Toniolo
Summary: This study has found the presence of enterovirus genomes in the pancreas of type 1 diabetes patients, suggesting a potential link between enterovirus infection and the development of type 1 diabetes.
Review
Virology
Generoso Bevilacqua
Summary: This study summarizes the research progress on MMTV/HMTV/HBRV since its discovery in the early 20th century, demonstrating the strong association between HBRV and breast cancer and PBC. The quantity and quality of scientific evidence supporting the existence of HBRV and its pathogenic role are emphasized.
Article
Biochemistry & Molecular Biology
Elisabetta Profumo, Elisa Maggi, Marzia Arese, Claudio Di Cristofano, Bruno Salvati, Luciano Saso, Rita Businaro, Brigitta Buttari
Summary: This study reveals that neuropeptide Y (NPY) can modulate the phenotype and functions of human macrophages, promoting their transition to a reparative phenotype that has therapeutic effects on atherosclerosis. NPY reduces lipid droplet accumulation and enhances autophagosome formation in macrophages. Additionally, NPY increases the activation of the antioxidant signaling pathway in macrophages, protecting cells from further damage in the inflammatory pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Raffaele Gaeta, Mariangela Morelli, Francesca Lessi, Chiara Maria Mazzanti, Michele Menicagli, Rodolfo Capanna, Lorenzo Andreani, Luca Coccoli, Paolo Aretini, Alessandro Franchi
Summary: This study aims to identify gene alterations in high-grade osteosarcoma (OS) patients using whole exome sequencing (WES) to find new potential prognostic biomarkers and therapeutic targets. Mutations in ARID1A, CREBBP, BRCA2 and RAD50 genes were found to be significantly correlated with poor response to neoadjuvant therapy and negatively influenced the progression-free survival time. Moreover, higher tumor mutational burden values were associated with worse prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Francesca Lessi, Mariangela Morelli, Sara Franceschi, Paolo Aretini, Michele Menicagli, Andrea Marranci, Francesco Pasqualetti, Carlo Gambacciani, Francesco Pieri, Gianluca Grimod, Vanna Zucchi, Samanta Cupini, Anna Luisa Di Stefano, Orazio Santo Santonocito, Chiara Maria Mazzanti
Summary: Circulating tumor cells (CTCs) are a vital factor in tumor recurrence and distant metastases. In this research, we aimed to improve the detection of CTCs in glioblastoma (GBM) and assess their genetic background compared to the primary tumor and its recurrence, confirming their origin from the parental tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ilaria Proietti, Luca Filippi, Ersilia Tolino, Nicoletta Bernardini, Francesca Svara, Federica Trovato, Claudio Di Cristofano, Vincenzo Petrozza, Oreste Bagni, Andrea Vizzaccaro, Nevena Skroza, Concetta Potenza
Summary: This study describes a successful treatment of a patient with BSC. The efficacy of Cemiplimab against BSC and other histopathological subtypes of BCC has not been fully elucidated, and the role of sequential or combination therapy with Cemiplimab and HHI in the management of BSC needs further investigation.
