Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation

Antisense Transcription in Loci Associated to Hereditary Neurodegenerative Diseases

(2019) Silvia Zucchelli et al.   MOLECULAR NEUROBIOLOGY

SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2019) Stefano Espinoza et al.   MOLECULAR THERAPY

The Role of Non-coding RNAs in Oncology

(2019) Frank J. Slack et al.   CELL

SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia

(2019) Carlotta Bon et al.   NUCLEIC ACIDS RESEARCH

mRNA structure regulates protein expression through changes in functional half-life

(2019) David M. Mauger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells

(2018) Emanuele Sasso et al.   mAbs

Identification of functional features of synthetic SINEUPs, antisense lncRNAs that specifically enhance protein translation

(2018) Hazuki Takahashi et al.   PLoS One

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

(2018) Lukas Trixl et al.   Wiley Interdisciplinary Reviews-RNA

SOX9: A genomic view of tissue specific expression and action

(2017) Aleisha Symon et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

(2017) Yuri V. Svitkin et al.   NUCLEIC ACIDS RESEARCH

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides

(2017) Jeffrey K. Bailey et al.   NUCLEIC ACIDS RESEARCH

The Yin and Yang of nucleic acid-based therapy in the brain

(2017) Stefano Gustincich et al.   PROGRESS IN NEUROBIOLOGY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Synthetic long non-coding RNAs [SINEUPs] rescue defective gene expression in vivo

(2016) Alessia Indrieri et al.   Scientific Reports

Identification of antisense long noncoding RNAs that function as SINEUPs in human cells

(2016) Aleks Schein et al.   Scientific Reports

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Engineering mammalian cell factories with SINEUP noncoding RNAs to improve translation of secreted proteins

(2015) Laura Patrucco et al.   GENE

N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

(2015) Oliwia Andries et al.   JOURNAL OF CONTROLLED RELEASE

SINEUPs: A new class of natural and synthetic antisense long non-coding RNAs that activate translation

(2015) S Zucchelli et al.   RNA Biology

SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells

(2015) Silvia Zucchelli et al.   Frontiers in Cellular Neuroscience

Widespread genome transcription: New possibilities for RNA therapies

(2014) Hazuki Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reprogramming human fibroblasts to pluripotency using modified mRNA

(2013) Pankaj K Mandal et al.   Nature Protocols

The contribution of pseudouridine to stabilities and structure of RNAs

(2013) Elzbieta Kierzek et al.   NUCLEIC ACIDS RESEARCH

Long non-coding RNAs as targets for cytosine methylation

(2013) Thomas Amort et al.   RNA Biology

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

(2013) Shobbir Hussain et al.   Cell Reports

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

(2012) Claudia Carrieri et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Nucleotide modifications in three functionally important regions of the Saccharomyces cerevisiae ribosome affect translation accuracy

(2009) Agnès Baudin-Baillieu et al.   NUCLEIC ACIDS RESEARCH

Identification of human haploinsufficient genes and their genomic proximity to segmental duplications

(2008) Vinh T Dang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS