Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Omega-3 Fatty Acid and its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy

(2020) Ayana Suzumura et al.   DIABETES

Melatonin attenuates vascular calcification by activating autophagy via an AMPK/mTOR/ULK1 signaling pathway

(2020) Wei Ren Chen et al.   EXPERIMENTAL CELL RESEARCH

Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR‐141‐mediated NLRP3 inflammasome and TGF‐β1/Smads signaling in diabetic cardiomyopathy

(2020) Hui Che et al.   FASEB JOURNAL

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

(2020) Zhigang Liu et al.   Nature Communications

Diabetic encephalopathy causes the imbalance of neural activities between hippocampal glutamatergic neurons and GABAergic neurons in mice

(2020) Chun Wang et al.   BRAIN RESEARCH

Tissue Plasminogen Activator Promotes TXNIP-NLRP3 Inflammasome Activation after Hyperglycemic Stroke in Mice

(2020) Saifudeen Ismael et al.   MOLECULAR NEUROBIOLOGY

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

(2020) Catherine R. Lammert et al.   NATURE

Melatonin: new insights on its therapeutic properties in diabetic complications

(2020) Mohammad Hossein Pourhanifeh et al.   Diabetology & Metabolic Syndrome

LncRNA-MIAT-Mediated miR-214-3p Silencing Is Responsible for IL-17 Production and Cardiac Fibrosis in Diabetic Cardiomyopathy

(2020) Yanqing Qi et al.   Frontiers in Cell and Developmental Biology

Blood-based analysis of 84 microRNAs identifies molecules deregulated in individuals with type-2 diabetes, risk factors for the disease or metabolic syndrome

(2020) Margaritis Avgeris et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The role of melatonin in targeting cell signaling pathways in neurodegeneration

(2019) Mayuri Shukla et al.   Annals of the New York Academy of Sciences

miR-22 and miR-214 targeting BCL9L inhibit proliferation, metastasis, and epithelial-mesenchymal transition by down-regulating Wnt signaling in colon cancer

(2019) Ruifang Sun et al.   FASEB JOURNAL

Type 2 diabetes induced oxidative brain injury involves altered cerebellar neuronal integrity and elemental distribution, and exacerbated Nrf2 expression: therapeutic potential of raffia palm (Raphia hookeri) wine

(2019) Ochuko L. Erukainure et al.   METABOLIC BRAIN DISEASE

Melatonin: Clinical Perspectives in Neurodegeneration

(2019) Daniel P. Cardinali   Frontiers in Endocrinology

Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time

(2019) Ronald McCarthy et al.   Frontiers in Endocrinology

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

(2019) Xuebin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin: A review of its potential functions and effects on neurological diseases

(2019) M. Gunata et al.   REVUE NEUROLOGIQUE

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Amentoflavone suppresses amyloid β1–42 neurotoxicity in Alzheimer's disease through the inhibition of pyroptosis

(2019) Ningning Zhao et al.   LIFE SCIENCES

Morphological and Pathological Characteristics of Brain in Diabetic Encephalopathy

(2018) Rui Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

(2018) Jie Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain atrophy in middle-aged subjects with Type 2 diabetes mellitus, with and without microvascular complications

(2018) Fang Fang et al.   Journal of Diabetes

Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy

(2018) Susan B. Gurley et al.   DIABETES

Evidence for Cortical Neuronal Loss in Male Type 2 Diabetic Goto-Kakizaki Rats

(2018) Shafaat Hussain et al.   JOURNAL OF ALZHEIMERS DISEASE

MiR-214 is an important regulator of the musculoskeletal metabolism and disease

(2018) Youqiang Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

(2018) Fan Yang et al.   Cell Death & Disease

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus

(2017) Nicole T. Milne et al.   Brain and Behavior

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment

(2016) Jih-Ing Chuang et al.   JOURNAL OF PINEAL RESEARCH

MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion

(2016) Hui Che et al.   MOLECULAR NEUROBIOLOGY

MiR-214-3p attenuates cognition defects via the inhibition of autophagy in SAMP8 mouse model of sporadic Alzheimer's disease

(2016) Yueqi Zhang et al.   NEUROTOXICOLOGY

Diabetic Cardiomyopathy: Catabolism Driving Metabolism

(2015) Z. V. Wang et al.   CIRCULATION

Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

(2015) Jieling Yang et al.   CURRENT OPINION IN IMMUNOLOGY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis

(2015) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy

(2014) María Muriach et al.   Oxidative Medicine and Cellular Longevity

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosis

(2011) William H. Hoffman et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Cell “Self-Eating” (Autophagy) Mechanism in Alzheimer's Disease

(2010) Sarah F. Funderburk et al.   MOUNT SINAI JOURNAL OF MEDICINE

A look inside the diabetic brain: Contributors to diabetes-induced brain aging

(2008) Shayna A. Wrighten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells

(2008) Patthara Kongsuphol et al.   JOURNAL OF PINEAL RESEARCH

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

(2007) A. Rami et al.   NEUROBIOLOGY OF DISEASE