Review
Oncology
Yalei Zhang, Ye Li, Kun Chen, Ling Qian, Peng Wang
Summary: Oncolytic viruses (OVs) are emerging as a promising therapeutic agent to overcome the immunosuppressive tumor microenvironment (TME) and enhance the efficacy of immunotherapy. Strategies involving OVs include serving as a cancer vaccine, expressing proinflammatory factors and immune checkpoint inhibitors, and regulating nonimmune stromal constituents. Optimization of preclinical models and achieving systemic delivery of OVs are crucial for the successful clinical translation in the future.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Wenhao Luo, Yawen Wang, Taiping Zhang
Summary: Pancreatic cancer is a growing global burden and remains one of the most lethal cancers of the gastrointestinal tract, resistant to traditional treatments. Oncolytic virus therapy, as a promising new treatment option, can selectively replicate in tumor cells and activate tumor-specific T-cells. However, its mono-therapeutic efficacy is controversial, especially for advanced patients, highlighting the need for combination therapies to improve outcomes and prevent recurrence.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Masahiro Kagabu, Naoto Yoshino, Kazuyuki Murakami, Hideki Kawamura, Yutaka Sasaki, Yasushi Muraki, Tsukasa Baba
Summary: In this study, the therapeutic potential of a triple-mutated oncolytic herpes virus (T-01) combined with an immune checkpoint inhibitor was evaluated for HPV-related cervical cancer in a murine model. The combination therapy showed comparable efficacy to anti-PD-L1 antibody alone when administered intratumorally or subcutaneously, and did not have a significant antitumor effect on the non-T-01-injected side. The combination therapy increased the number of tumor specific T-cells and had a cytotoxic effect on stimulated T-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Masmudur M. Rahman, Grant McFadden
Summary: Oncolytic viruses (OVs) are a novel cancer treatment modality that selectively target and kill cancer cells while sparing normal ones. Engineered OVs show great potential in clinical trials, but combination therapies with other treatments may further improve their efficacy.
Article
Immunology
Mathieu J. F. Crupi, Zaid Taha, Thijs J. A. Janssen, Julia Petryk, Stephen Boulton, Nouf Alluqmani, Anna Jirovec, Omar Kassas, Sarwat T. Khan, Sydney Vallati, Emily Lee, Ben Zhen Huang, Michael Huh, Larissa Pikor, Xiaohong He, Ricardo Marius, Bradley Austin, Jessie Duong, Adrian Pelin, Serge Neault, Taha Azad, Caroline J. Breitbach, David F. Stojdl, Michael F. Burgess, Scott McComb, Rebecca Auer, Jean-Simon Diallo, Carolina S. Ilkow, John Cameron Bell
Summary: This study proposes a novel combination strategy for the treatment of colorectal cancers using oncolytic vaccinia virus to enhance immune-payload delivery and boost T cell responses within tumors. TCEs targeting CEACAM5 and CD3 stimulate robust activation of CD4 and CD8-positive T cells in in vitro co-culture models with colorectal cancer cells, and lead to regression of colorectal tumors in syngeneic and xenograft mouse models.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ramazan Rezaei, Hadi Esmaeili Gouvarchin Ghaleh, Mahdieh Farzanehpour, Ruhollah Dorostkar, Reza Ranjbar, Masoumeh Bolandian, Majid Mirzaei Nodooshan, Akbar Ghorbani Alvanegh
Summary: CAR T-cell therapy has shown success in hematologic malignancies but faces obstacles in solid tumors, which oncolytic virotherapy can help overcome by synergizing with CAR T-cell application and enhancing therapeutic effects. Researchers can use oncolytic virotherapy to engineer viruses that selectively deliver specific therapeutic agents to the tumor environment.
CANCER GENE THERAPY
(2022)
Review
Medical Laboratory Technology
Noraini Abd-Aziz, Chit Laa Poh
Summary: Oncolytic virotherapy is a therapeutic approach that utilizes replication-competent viruses to selectively kill cancer cells, but it faces limitations such as viral delivery, tumor penetration, and antiviral immune responses. Strategies to overcome these limitations are crucial for its effective application in preclinical and clinical trials.
TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Seyed-Mahmood Seyed-Khorrami, Arezou Azadi, Nasrin Rastegarvand, Ala Habibian, Hoorieh Soleimanjahi, Marek J. Los
Summary: Immunotherapy and virotherapy have emerged as new methods for cancer treatment, with better specificity and outcomes. Applying these strategies in the treatment of malignancies is of great significance, based on advances in understanding cancer cell biology and oncolytic viruses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Oncology
Bart Spiesschaert, Katharina Angerer, John Park, Guido Wollmann
Summary: Combinations of oncolytic viruses with specific small molecule compounds can help overcome limitations in their ability to replicate and kill tumors in clinical settings. This review focuses on mechanisms by which small molecules can synergize with oncolytic viruses to enhance viral replication, tumor cell killing, and antitumor immune responses.
Review
Hematology
Xuejin Gao, Jile Liu, Rui Sun, Jingkun Zhang, Xinping Cao, Yi Zhang, Mingfeng Zhao
Summary: The combination of CAR-T cell therapy and oncolytic virus therapy has been shown to be beneficial in the treatment of hematological malignancies, improving the treatment effect and complementing the disadvantages of individual therapies.
ANNALS OF HEMATOLOGY
(2023)
Review
Immunology
Maryam Sadri, Alireza Najafi, Ali Rahimi, Nafiseh Behranvand, Mohammad Hossein Kazemi, Hossein Khorramdelazad, Reza Falak
Summary: Researchers have explored novel strategies for cancer treatment in the past few decades, particularly using oncolytic viruses (OVs) alone or in combination with other anticancer therapies. However, the immunosuppressive tumor microenvironment (TME) poses a significant challenge for virotherapy. In this review, the authors discuss the dual effect of hypoxia on different types of OVs and propose strategies to optimize therapeutic methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Virology
Zhijian Huang, Hongen Guo, Lin Lin, Shixiong Li, Yong Yang, Yuanyuan Han, Weiwei Huang, Jialiang Yang
Summary: Oncolytic viruses (OVs) are a promising and safe measure for cancer treatment as they selectively kill tumor cells and activate the immune system. Genetically engineered OVs expressing immune regulatory factors have been developed to enhance antitumor effects. In addition, combined therapies of OVs with other immunotherapies have shown clinical potential. A comprehensive review examining the mechanisms of tumor clearance by OVs and strategies to enhance their effects is needed. This study provides a review on immune regulatory factors in OVs and their combined therapies, facilitating the broader application of OV in cancer treatment.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Shyambabu Chaurasiya, Hannah Valencia, Zhifang Zhang, Sang-In Kim, Annie Yang, Jianming Lu, Yanghee Woo, Susanne G. Warner, Nicholas J. Ede, Yuman Fong
Summary: Researchers have modified the CF33 virus to selectively replicate and image tumors in cancer cells by adding the hNIS reporter gene. The CF33-hNIS virus efficiently kills liver cancer cells and exhibits characteristics of immunogenic cell death. In a liver cancer mouse model, a single dose of the CF33-hNIS virus showed antitumor efficacy and significantly increased survival. Additionally, low doses of the virus allowed for noninvasive PET imaging of tumors. In conclusion, CF33-hNIS is safe and effective in controlling tumor xenografts and facilitates noninvasive tumor imaging.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Oncology
Guosong Wang, Jiali Cao, Mengxuan Gui, Pengfei Huang, Liang Zhang, Ruoyao Qi, Ruiqi Chen, Lina Lin, Qiangyuan Han, Yanhua Lin, Tian Chen, Peiqing He, Jian Ma, Rao Fu, Junping Hong, Qian Wu, Hai Yu, Junyu Chen, Chenghao Huang, Tianying Zhang, Quan Yuan, Jun Zhang, Yixin Chen, Ningshao Xia
Summary: A live-attenuated swine pseudorabies virus (PRV-LAV) was identified as a promising oncolytic agent with broad-spectrum antitumor activity. PRV-LAV infects cancer cells via the NRP1/EGFR signaling pathway and induces cancer cell apoptosis by inducing endoplasmic reticulum (ER) stress. Furthermore, PRV-LAV can reprogram the tumor microenvironment, increase immune cell infiltration, and restore CD8+ T cell function against cancer. Combination of PRV-LAV with immune checkpoint inhibitors (ICIs) showed a significant synergistic effect.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Immunology
Mahdie Jafari, Maryam Kadkhodazadeh, Mina Bahrololoumi Shapourabadi, Nasser Hashemi Goradel, Mohammad Ali Shokrgozar, Arash Arashkia, Shahriyar Abdoli, Zahra Sharifzadeh
Summary: Despite the approval of new drugs and targeted therapies, most cancer types remain difficult to treat due to tumor heterogeneity, immune system evasion, and the complex interaction between the tumor microenvironment and immune cells. Oncolytic virus (OV) immunotherapy, which uses viruses to selectively replicate within cancer cells and activate the immune system, has shown promising results. However, challenges such as off-target side effects and non-specific uptake limit its effectiveness as monotherapy. Combining OV with other biotherapeutic agents, such as antibodies and CAR-T cells, has been proposed to enhance the anti-tumor activities of OV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pin Wan, Qi Zhang, Weiyong Liu, Yaling Jia, Sha Ai, Tianci Wang, Wenbiao Wang, Pan Pan, Ge Yang, Qi Xiang, Siyu Huang, Qingyu Yang, Wei Zhang, Fang Liu, Qiuping Tan, Wen Zhang, Kailang Wu, Yingle Liu, Jianguo Wu
Article
Oncology
Franziska M. Ippen, Christopher A. Alvarez-Breckenridge, Benjamin M. Kuter, Alexandria L. Fink, Ivanna Bihun, Matthew Lastrapes, Tristan Penson, Stephen P. Schmidt, Gregory R. Wojtkiewicz, Jianfang Ning, Megha Subramanian, Anita Giobbie-Hurder, Maria Martinez-Lage, Scott L. Carter, Daniel P. Cahill, Hiroaki Wakimoto, Priscilla K. Brastianos
CLINICAL CANCER RESEARCH
(2019)
Article
Virology
Pan Pan, Qi Zhang, Weiyong Liu, Wenbiao Wang, Zizhao Lao, Wei Zhang, Miaomiao Shen, Pin Wan, Feng Xiao, Fang Liu, Wen Zhang, Quiping Tan, Xiaohong Liu, Kailang Wu, Yingle Liu, Geng Li, Jianguo Wu
JOURNAL OF VIROLOGY
(2019)
Article
Oncology
Fumi Higuchi, Hiroaki Nagashima, Jianfang Ning, Mara V. A. Koerner, Hiroaki Wakimoto, Daniel P. Cahill
CLINICAL CANCER RESEARCH
(2020)
Article
Geosciences, Multidisciplinary
Fan Chen, Li Chen, Wei Zhang, Jing Yuan, Kanghe Zhang
Summary: Through analyzing the effective discharges and their variations after the construction of the Three Gorges Dam on the Yangtze River, it was found that different sites exhibit bimodal effective discharge curves, with the increase in unsaturation degrees of pre-dam effective discharges leading to an increase in effective discharges, while flow regulation resulted in a decrease. Additionally, in the middle and lower reaches of the river, the bankfull discharge exceeds the effective discharge.
FRONTIERS OF EARTH SCIENCE
(2022)
Article
Neurosciences
Ziang Gao, Xixiang Chen, Rong Xiang, Wei Zhang, Lu Tan, Wenjun Fan, Peiqiang Liu, Hao Lv, Yu Xu
Summary: This study used resting-state functional magnetic resonance imaging to discover functional changes in brain activity in patients with allergic rhinitis, including hypoactivity in the precuneus and hyperactivity in the anterior cingulate cortex. These changes were significantly correlated with symptom scores and quality of life measures. Further investigation into brain activity in allergic rhinitis patients may provide new insights for clinical interventions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Cheng Jiang, Jiechun Zhang, Huiwen Xie, Huiting Guan, Rui Li, Caixia Chen, Hongzhen Dong, You Zhou, Wei Zhang
Summary: Research findings demonstrate that baicalein may serve as a new clinical therapeutic strategy in ALI by restoring mitochondrial function, suppressing inflammatory responses, and reducing the severity of lung injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Letter
Immunology
Wei Zhang, Linfen Huang, Gang Ye, Qibin Geng, Nwando Ikeogu, Morgan Harris, Gayathri Dileepan, Kristina Burrack, Lanying Du, Anne Frosch, Fang Li
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhiyi Han, Wenxing Feng, Rui Hu, Qinyu Ge, Xinfeng Sun, Wenfeng Ma, Wei Zhang, Shaomin Xu, Bolin Zhan, Lai Zhang, Qun Li, Xiaozhou Zhou
Summary: This study investigated the differential expression and potential diagnostic biomarkers of circRNAs in hepatocellular carcinoma (HCC), identifying several DE-circRNAs and constructing a regulatory network. The results suggest multiple circRNAs may serve as potential biomarkers for HCC and provide insights into potential therapeutic targets for HCC.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Virology
Qibin Geng, Ke Shi, Gang Ye, Wei Zhang, Hideki Aihara, Fang Li
Summary: The omicron variant of SARS-CoV-2, which is highly contagious and fast-spreading, shows enhanced binding to the receptor ACE2 in the respiratory tracts. The mutations in the omicron spike protein cause structural rearrangements at the RBD/ACE2 interface, leading to increased ACE2 binding. This study provides insights into the tissue tropism and receptor recognition of the omicron variant.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Juan Shi, Jian Zheng, Wanbo Tai, Abhishek K. Verma, Xiujuan Zhang, Qibin Geng, Gang Wang, Xiaoqing Guan, Moffat M. Malisheni, Abby E. Odle, Wei Zhang, Fang Li, Stanley Perlman, Lanying Du
Summary: This study identified a non-neutralizing epitope on the receptor-binding domain (RBD) of SARS-CoV-2 spike protein and developed a mutant RBD vaccine with enhanced neutralizing activity against multiple variants, including Delta and Omicron strains. The mutant vaccine also improved the protective efficacy of the prototypic RBD vaccine against SARS-CoV-2 infection.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Wei Zhang, Ke Shi, Qibin Geng, Gang Ye, Hideki Aihara, Fang Li
Summary: The omicron variant's RBD showed adaptation to mouse ACE2 before infecting humans, as confirmed by crystal structure analysis. (Animal experimentation)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Wei Zhang, Ke Shi, Qibin Geng, Morgan Herbst, Michael Wang, Linfen Huang, Fan Bu, Bin Liu, Hideki Aihara, Fang Li
Summary: Understanding the evolutionary strategies of the SARS-CoV-2 omicron variant is crucial for comprehending the COVID-19 pandemic and preventing future coronavirus pandemics. In this study, the crystal structures of the receptor-binding domains (RBDs) from different omicron subvariants were determined, revealing how individual RBD residues evolved structurally in omicron subvariants and adapted to human ACE2. The findings suggest that both non-human animals and immune evasion may have played a role in driving omicron evolution at different stages of the pandemic.
JOURNAL OF VIROLOGY
(2023)