Review
Biochemistry & Molecular Biology
Huixia Liu, Yujuan Li, Jing Xiong
Summary: The kidney maintains a relatively stable level of oxygen partial pressure through a complex interplay of various factors. Hypoxia is a key factor in the pathogenesis of acute kidney injury and chronic kidney disease, as well as in the development of renal cancer.
Review
Endocrinology & Metabolism
Xuejiao Wei, Yue Hou, Mengtuan Long, Lili Jiang, Yujun Du
Summary: Renal fibrosis is caused by renal tissue damage and repair response disorders, leading to chronic renal failure if not effectively blocked. HIF-1α plays an important role in renal fibrosis and glucose metabolism by regulating the expression of proteins related to aerobic glycolysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmao Chen, Suet Mien Tan, Siew Cheng Wong
Summary: A large number of neutrophils infiltrate tumors and contribute to the inflammatory tumor microenvironment. The metabolic status of these neutrophils and their role in tumor progression were investigated in a mouse model of pancreatic ductal adenocarcinoma (PDAC). Tumor-infiltrating neutrophils showed enhanced glycolytic activity compared to neutrophils from the bone marrow and blood of the same mouse. Deletion of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in neutrophils reduced tumor burden and improved survival in the mouse model, indicating a potential target for metabolic modulation in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yun Zhang, Guo-Xin Zhang, Li-Shuang Che, Shu-Han Shi, Yue-Ting Li
Summary: The expression of miR-212 was significantly increased in patients with renal interstitial fibrosis and UUO mice, and it was found to promote the progression of renal interstitial fibrosis by targeting HIF1AN.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ji Young Kim, Eun Jung Lee, Yuri Ahn, Sujin Park, Yu Jeong Bae, Tae Gyun Kim, Sang Ho Oh
Summary: The study demonstrates that CTSL is a novel target gene of HIF-1 alpha and plays a role in melanosome degradation in melanocytes through lysosomal activity during autophagosome-lysosome fusion. Under autophagy-inducing starvation conditions, the expression of HIF-1 alpha and CTSL is upregulated in melan-a cells. Inhibition of conversion of pro-CTSL to mature CTSL leads to accumulation of certain proteins due to decreased lysosomal activity in the autophagic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Niya L. Morris, David N. Michael, Kathryn M. Crotty, Sarah S. Chang, Samantha M. Yeligar
Summary: This study investigated the effects of alcohol on the metabolism of alveolar macrophages, revealing that chronic alcohol exposure leads to a shift towards glycolysis in alveolar macrophages, resulting in reduced phagocytic capacity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sara da Silva-Ferreira, Claudio Duarte-Oliveira, Daniela Antunes, Catarina Barbosa-Matos, Ana Mendes-Frias, Egidio Torrado, Sandra Costa, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho
Summary: Chronic pulmonary aspergillosis is a devastating disease with increasing prevalence worldwide. The characteristic inflammation limits the effectiveness of antifungal therapies. The study shows that hypoxia-inducible factor 1 alpha (HIF-1 alpha) plays a central role in regulating neutrophil function and fungal infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Lijuan Hu, Xiaoqing Xu, Xijuan Chen, Shuai Qiu, Qiuju Li, Dapeng Zhang, Feng Wang
Summary: In this study, it was investigated whether EGCG can decrease HIF-1α expression in pancreatic cancer cells. The results showed that EGCG reduced both the production and stability of HIF-1α, leading to decreased cell growth and tumor development. This study revealed the mechanism of EGCG inhibition in pancreatic cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Cell Biology
Shuai Li, Jingyuan Zhao, Yan Xi, Jiaqi Ren, Yanna Zhu, Yan Lu, Deshi Dong
Summary: This study investigated the molecular mechanism of Dl-3-n-butylphthalide and found that it exhibited a neuroprotective effect on stroke by promoting ubiquitination and degradation of hypoxia inducible factor-1a and inhibiting cell apoptosis.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biology
Milica Mandic, Kaitlyn Flear, Pearl Qiu, Yihang K. Pan, Steve F. Perry, Kathleen M. Gilmour
Summary: HIF-1α is important for hypoxic survival in zebrafish, particularly in relation to their ability to perform aquatic surface respiration (ASR). When zebrafish are prevented from accessing the surface during severe hypoxia, their survival is significantly compromised. However, when they are allowed to access the surface, there is no difference in survival between wild-type and HIF-1α knockout fish. ASR mitigates the negative effects of HIF-1α loss, with knockouts initiating ASR at a higher oxygen concentration and performing ASR for longer than wild-types.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Wenpeng Cao, Shan Lei, Zhirui Zeng, Chaolun Xiao, Baofei Sun, Peng Xie, Yumei Li, Daopeng Luo, Wenfeng Yu
Summary: This study identified TRAA2A as an important hypoxia-associated gene in pancreatic cancer, which is associated with tumor progression and metastasis. TRAA2A is regulated by hypoxia-inducible factor HIF1 alpha and promotes the proliferation and motility of pancreatic cancer cells via activation of the AKT pathway. Therefore, TRAA2A may serve as a novel molecular target for investigating the hypoxic response of pancreatic cancer cells.
Review
Oncology
Huan Chen, Jing Chen, Huixin Yuan, Xiuhui Li, Weihua Li
Summary: Hypoxia-induced high expression of HIF-1 alpha is associated with invasion and metastasis in HCC. Modulating HIF-1 alpha can reduce drug resistance and improve prognosis, making it a potential critical target for inhibiting HCC metastasis in the future.
Review
Oncology
Liyun Yong, Shasha Tang, Haixin Yu, Hongyi Zhang, Yi Zhang, Yuan Wan, Fengfeng Cai
Summary: Breast cancer is the most common cancer in women, and drug resistance is a persistent clinical challenge. Hypoxia-inducible Factor-1 Alpha (HIF-1α) plays a crucial role in regulating cellular response to hypoxia and is closely associated with multidrug resistance in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Patrick K. Tamukong, Paige Kuhlmann, Sungyong You, Shengchen Su, Yanping Wang, Samantha Yoon, Jun Gong, Robert A. Figlin, Jessica L. Janes, Stephen J. Freedland, Susan Halabi, Eric J. Small, Brian I. Rini, Hyung L. Kim
Summary: This study evaluated genes within the HIF pathway as predictors of survival in metastatic ccRCC patients, identifying key factors associated with patient survival and disease progression among multiple genes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pathology
Jingrong Qian, Hongxue Meng, Bowen Lv, Jie Wang, Yingying Lu, Wenhui Li, Shu Zhao
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Pharmacology & Pharmacy
Siqi Wang, Yan Gao, Zhao Liu, Chunyu Yang, Na An, Hongxue Meng, Mei Yan, Guofan Qu, Chongshen Guo
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Oncology
Rintaro Ohe, Hong-Xue Meng, Akane Yamada, Naing Ye Aung, Takanobu Kabasawa, Yuka Tamura, Aya Utsunomiya, Nobuyuki Tamazawa, Ichiro Kawamura, Takumi Kitaoka, Kazushi Suzuki, Ryo Yanagiya, Tomomi Toubai, Kenichi Ishizawa, Mitsunori Yamakawa
HEMATOLOGICAL ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Guorui Peng, Hongxue Meng, Hongxin Pan, Wentao Wang
Summary: The study found that circ 001418 can promote cell growth and metastasis of bladder carcinoma through miR-1297 and EphA2. Over-expression of circ 001418 can also suppress the expression of FADD protein, thereby driving the progression of bladder cancer.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Review
Pathology
Xinxin Yang, Anchao Zhu, Hongxue Meng
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Oncology
Xinxin Yang, Qi You, Guodong Yao, Jingshu Geng, Rong Ma, Hongxue Meng
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Genetics & Heredity
Xinxin Yang, Yunjing Hou, Jiashi Geng, Jingshu Geng, Hongxue Meng
FRONTIERS IN GENETICS
(2020)
Article
Oncology
Linlu Tian, Hongxue Meng, Xiao Dong, Xinlei Li, Zilin Shi, Hulun Li, Lie Zhang, Yue Yang, Ruijie Liu, Chunying Pei, Bo Li, Hongwei Xu, Rui Li
Summary: Studies have shown that overexpression of IRGM is associated with human melanoma progression and poor patient survival. Specifically, IRGMb is responsible for this correlation, and the mechanism by which IRGM promotes melanoma cell survival is mainly through autophagy.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Erliang Guo, Lunhua Guo, Changming An, Cong Zhang, Kaibin Song, Guohui Wang, Chunbin Duan, Xiwei Zhang, Xianguang Yang, Zhennan Yuan, Junnan Guo, Ji Sun, Hongxue Meng, Rui Chang, Xiaomei Li, Cheng Xiu, Xionghui Mao, Susheng Miao
Article
Pathology
Anchao Zhu, Xinxin Yang, Lijing Bai, Yunjing Hou, Chenxu Guo, Di Zhao, Meina Wen, Ping Jiang, Yuyan Liu, Ying Huang, Chen Li, Hongxue Meng
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Cell Biology
Huining Li, Xinxin Yang, Guodong Yao, Yanxiang Zhang, Yangyang Xu, Yan Cao, Xushu An, Haibo Li, Hui Chen, Jingshu Geng, Dawei Yuan, Xiaoming Jin, Hongxue Meng
HISTOLOGY AND HISTOPATHOLOGY
(2020)
Article
Cell Biology
Rintaro Ohe, Naing Ye Aung, Yuka Tamura, Takanobu Kabasawa, Aya Utsunomiya, Nobuyuki Tamazawa, Takumi Kitaoka, Hong-Xue Meng, Kenichi Shibata, Mitsunori Yamakawa
HISTOLOGY AND HISTOPATHOLOGY
(2020)
Article
Oncology
Jingrong Qian, Hongxue Meng, Bowen Lv, Jie Wang, Yingying Lu, Liju Su, Shu Zhao, Wenhu Li
Article
Pharmacology & Pharmacy
Hong-xue Meng, Xin-xin Yang, Rui-qi Liu, Jun-jie Bao, Yun-jing Hou, Ji Sun, Su-sheng Miao, Guo-fan Qu
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2020)