Article
Biotechnology & Applied Microbiology
Qiao Gu, Wenjie Hou, Lijuan Shi, Zonghao Zhu, Huan Liu, Xiaozhou He
Summary: This study reveals that circMCTP2 promotes the progression of bladder carcinoma by regulating the expression of miR-498 and MDM2. These findings offer a new strategy for the early diagnosis and treatment of bladder carcinoma.
Article
Dentistry, Oral Surgery & Medicine
Shujuan Yan, Meng Wang
Summary: This study identified the regulatory axis of HCG11/miR-1297/EphA2 in SACC, which may provide novel therapeutic targets for SACC.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Article
Oncology
Liping Luo, Pingping Miao, Yao Ming, Jie Tao, Hongchun Shen
Summary: In this study, it was found that the expression of circZFR was upregulated in bladder cancer patients and positively correlated with patient survival rates. Inhibiting circZFR expression suppressed the proliferation, migration, and invasion of BCa cells. Additionally, circZFR was shown to promote BCa progression by upregulating WNT5A expression through sponging miR-545 and miR-1270.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yuxi Ou, Xiyu Dai, Xinan Chen, Yiling Chen, Siqi Wu, Quan Zhou, Chen Yang, Haowen Jiang
Summary: This study demonstrated that the circAFAP1/miR-374b-3p/VEGFA axis plays a critical role in the progression and development of ccRCC, which may serve as novel biomarkers and therapeutic targets.
CELL DEATH DISCOVERY
(2022)
Article
Multidisciplinary Sciences
Yiqing Guo, Hua Zheng, Jie Yin, Huaming Wang
Summary: Recent evidence shows that circ-ITCH exerts an inhibitory effect on the progression of papillary thyroid cancer by affecting the circ-ITCH/miR-22-3p/CBL axis. The A allele in rs4911154 is associated with shorter doubling time of thyroid nodules and decreased CBL expression, contributing to increased malignancy.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Wenqi Chen, Yuehua Li, Jing Zhong, Gebo Wen
Summary: The study elucidated that circ-PRKCI may promote the viability, invasion and migration of HCC cells by sponging miR-1294 and miR-186-5p to upregulate FOXK1 expression levels.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Marwa Matboli, Mohmed Kamal Hassan, Mahmoud A. Ali, Mohamed Tarek Mansour, Waheba Elsayed, Reham Atteya, Hebatallah Said Aly, Mahmoud El Meteini, Hesham Elghazaly, Sherif El-Khamisy, Sara H. A. Agwa
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death in Egypt. This study reveals a novel axis involving hsa-circ-0000221, miR-661, and PTPN11 mRNA in HCC pathogenesis, suggesting a tumor-suppressive role of hsa-circ-0000221 through miR-661 inhibition and subsequent PTPN11 mRNA increase. The findings highlight the potential use of circRNAs as molecular biomarkers in cancer research.
Article
Oncology
Eisuke Tomiyama, Kazutoshi Fujita, Kyosuke Matsuzaki, Ryohei Narumi, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yoko Koh, Makoto Matsushita, Yujiro Hayashi, Mamoru Hashimoto, Eri Banno, Taigo Kato, Koji Hatano, Atsunari Kawashima, Motohide Uemura, Ryo Ukekawa, Tetsuya Takao, Shingo Takada, Hirotsugu Uemura, Jun Adachi, Takeshi Tomonaga, Norio Nonomura
Summary: In this study, a potential diagnostic biomarker for bladder cancer was identified and evaluated by analyzing cancer-specific proteins secreted in urinary extracellular vesicles (uEVs). An enzyme-linked immunosorbent assay (ELISA) was developed to quantify the uEV protein biomarker, leading to a non-invasive early clinical diagnosis of bladder cancer. The study also revealed the functional role of Ephrin type-A receptor 2 (EphA2) in bladder cancer progression.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Xuan Guo, Ziying Wang, Xue Deng, Yantong Lu, Xuhui Huang, Juze Lin, Xiaohe Lan, Qiao Su, Changjun Wang
Summary: This article investigates the role and biological function of circular RNA (circRNA) in the occurrence of hepatocellular carcinoma (HCC). The study found that circITCH is downregulated in HCC cells and regulates proliferation, invasion, and apoptosis of HCC through interaction with miR-184. Additionally, circITCH may serve as a potential prognostic marker and therapeutic target for HCC.
Article
Cell Biology
Ganghua Yang, Qinhong Xu, Yong Wan, Lei Zhang, Lin Wang, Fandi Meng
Summary: This study demonstrated the crucial role of circ-CSPP1 in hepatocellular carcinoma (HCC) by regulating the expression of miR-493-5p and HMGB1, thereby suppressing HCC development both in vitro and in vivo.
CELLULAR SIGNALLING
(2021)
Article
Medicine, Research & Experimental
Xiwu Ouyang, Lemeng Feng, Lei Yao, Yao Xiao, Xianyu Hu, Gewen Zhang, Guodong Liu, Zhiming Wang
Summary: The study highlights the oncogenic role of TR4 in the development of papillary thyroid cancer (PTC), driving PTC progression by promoting cell invasion and migration. The TR4/circFLNA/miR-149-5p/MMP9 signaling axis plays a central role in cell invasion and migration of PTC cells, suggesting that targeting this pathway may be an alternative option for metastatic PTC patients.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Pathology
Elahe Abdollahi, Hossein Mozdarani
Summary: Assessing the radiosensitivity of cells can help select appropriate treatment regimens and minimize adverse effects in breast cancer patients. The study found that circ-HIPK3 and circ-PVT1 may serve as promising biomarkers for predicting breast cancer and cellular radiosensitivity.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Zongze He, Meixiong Cheng, Junting Hu, Lingtong Liu, Ping Liu, Longyi Chen, Deqian Cao, Jian Tang
Summary: ADM expression is upregulated in TMZ-resistant glioma samples. Knocking down ADM enhances the suppressive effects of TMZ on glioma cell viability, promotes cell apoptosis, and inhibits mitochondrial membrane potential. Moreover, ADM knockdown also enhances TMZ effects on Bax/Bcl-2, Akt phosphorylation, and Erk1/2 phosphorylation. miR-1297 directly targets ADM and inhibits ADM expression. miR-1297 overexpression exerts similar effects to ADM knockdown on TMZ-treated glioma cells. Inhibition of miR-1297 attenuates TMZ treatment on glioma cells, and ADM knockdown partially attenuates the effects of miR-1297 inhibition on TMZ-treated glioma cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qian Zhou, Chengang Lei, Fenghe Cui, Hao Chen, Xianzhao Cao
Summary: circ-ATIC promotes the proliferation and invasion of ESCC by regulating the miR-1294/PBX3 axis. The study found that circ-ATIC and its host gene ATIC were significantly increased in ESCC tissues and cells. Knocking down circ-ATIC reduced the proliferation and invasion ability of ESCC cells and inhibited the EMT process. It was also discovered that circ-ATIC can bind to miR-1294 and serve as a sponge RNA, resulting in the upregulation of PBX3.
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The study revealed that miR-1297 can inhibit proliferation and tumor growth in osteosarcoma by directly targeting CCND2. Overexpression of miR-1297 significantly suppressed CCND2 protein expression and resulted in similar phenotypic effects as CCND2 downregulation. Therefore, miR-1297 may represent a novel therapeutic target for osteosarcoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pathology
Jingrong Qian, Hongxue Meng, Bowen Lv, Jie Wang, Yingying Lu, Wenhui Li, Shu Zhao
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Pharmacology & Pharmacy
Siqi Wang, Yan Gao, Zhao Liu, Chunyu Yang, Na An, Hongxue Meng, Mei Yan, Guofan Qu, Chongshen Guo
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Oncology
Rintaro Ohe, Hong-Xue Meng, Akane Yamada, Naing Ye Aung, Takanobu Kabasawa, Yuka Tamura, Aya Utsunomiya, Nobuyuki Tamazawa, Ichiro Kawamura, Takumi Kitaoka, Kazushi Suzuki, Ryo Yanagiya, Tomomi Toubai, Kenichi Ishizawa, Mitsunori Yamakawa
HEMATOLOGICAL ONCOLOGY
(2020)
Review
Pathology
Xinxin Yang, Anchao Zhu, Hongxue Meng
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Oncology
Xinxin Yang, Qi You, Guodong Yao, Jingshu Geng, Rong Ma, Hongxue Meng
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Xin Gu, Hongxue Meng, Jia Wang, Ruitao Wang, Muyang Cao, Siyu Liu, Hui Chen, Yangyang Xu
Summary: In renal cell carcinoma, the expression of galectin-3 and HIF-1α is significantly elevated, and hypoxia can further promote their expression. HIF-1α plays a critical role in the regulation of galectin-3 in RCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yun-jing Hou, Xin-xin Yang, Rui-qi Liu, Di Zhao, Chen-xu Guo, An-chao Zhu, Mei-na Wen, Zhao Liu, Guo-fan Qu, Hong-xue Meng
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Genetics & Heredity
Xinxin Yang, Yunjing Hou, Jiashi Geng, Jingshu Geng, Hongxue Meng
FRONTIERS IN GENETICS
(2020)
Article
Oncology
Linlu Tian, Hongxue Meng, Xiao Dong, Xinlei Li, Zilin Shi, Hulun Li, Lie Zhang, Yue Yang, Ruijie Liu, Chunying Pei, Bo Li, Hongwei Xu, Rui Li
Summary: Studies have shown that overexpression of IRGM is associated with human melanoma progression and poor patient survival. Specifically, IRGMb is responsible for this correlation, and the mechanism by which IRGM promotes melanoma cell survival is mainly through autophagy.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Erliang Guo, Lunhua Guo, Changming An, Cong Zhang, Kaibin Song, Guohui Wang, Chunbin Duan, Xiwei Zhang, Xianguang Yang, Zhennan Yuan, Junnan Guo, Ji Sun, Hongxue Meng, Rui Chang, Xiaomei Li, Cheng Xiu, Xionghui Mao, Susheng Miao
Article
Pathology
Anchao Zhu, Xinxin Yang, Lijing Bai, Yunjing Hou, Chenxu Guo, Di Zhao, Meina Wen, Ping Jiang, Yuyan Liu, Ying Huang, Chen Li, Hongxue Meng
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Cell Biology
Huining Li, Xinxin Yang, Guodong Yao, Yanxiang Zhang, Yangyang Xu, Yan Cao, Xushu An, Haibo Li, Hui Chen, Jingshu Geng, Dawei Yuan, Xiaoming Jin, Hongxue Meng
HISTOLOGY AND HISTOPATHOLOGY
(2020)
Article
Oncology
Jingrong Qian, Hongxue Meng, Bowen Lv, Jie Wang, Yingying Lu, Liju Su, Shu Zhao, Wenhu Li
Article
Pharmacology & Pharmacy
Hong-xue Meng, Xin-xin Yang, Rui-qi Liu, Jun-jie Bao, Yun-jing Hou, Ji Sun, Su-sheng Miao, Guo-fan Qu
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2020)