The Collision of Meta-Inflammation and SARS-CoV-2 Pandemic Infection

SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics

(2020) Qing Cao et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

(2020) Furong Liu et al.   Clinical Gastroenterology and Hepatology

The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic

(2020)   EUROPEAN JOURNAL OF HUMAN GENETICS

Association between age and clinical characteristics and outcomes of COVID-19

(2020) Yang Liu et al.   EUROPEAN RESPIRATORY JOURNAL

Pathophysiology of COVID-19: Why Children Fare Better than Adults?

(2020) Nitin Dhochak et al.   INDIAN JOURNAL OF PEDIATRICS

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair

(2020) Frank M. Davis et al.   JOURNAL OF IMMUNOLOGY

Prevention of COVID-19 in Older Adults: A Brief Guidance from the International Association for Gerontology and Geriatrics (IAGG) Asia/Oceania Region

(2020) Jagadish K. Chhetri et al.   Journal of Nutrition Health & Aging

Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis

(2020) Tu-Hsuan Chang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

(2020) Matthew J Cummings et al.   LANCET

Obesity could shift severe COVID-19 disease to younger ages

(2020) David A Kass et al.   LANCET

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Endocrine and metabolic link to coronavirus infection

(2020) Stefan R. Bornstein et al.   Nature Reviews Endocrinology

Clinical Characteristics of Covid-19 in New York City

(2020) Parag Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Morbid Obesity as an Independent Risk Factor for COVID‐19 Mortality in Hospitalized Patients Younger than 50

(2020) Eyal Klang et al.   Obesity

The role of adipocytes and adipocyte‐like cells in the severity of COVID‐19 infections

(2020) Ilja L. Kruglikov et al.   Obesity

Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?

(2020) Paul MacDaragh Ryan et al.   Obesity

Obesity is associated with worse outcomes in COVID‐19: Analysis of Early Data From New York City

(2020) Kaveh Hajifathalian et al.   Obesity

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 ( DPP4 ) in disease severity?

(2020) Margaret F. Bassendine et al.   Journal of Diabetes

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

The Perfect Storm: Coronavirus (Covid-19) Pandemic Meets Overfat Pandemic

(2020) Philip B. Maffetone et al.   Frontiers in Public Health

Association of Initial Viral Load in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients with Outcome and Symptoms

(2020) Kimon V. Argyropoulos et al.   AMERICAN JOURNAL OF PATHOLOGY

Diabetic ketoacidosis precipitated by Covid-19 in a patient with newly diagnosed diabetes mellitus

(2020) Ying Jie Chee et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York

(2020) Leonidas Palaiodimos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

New-Onset Diabetes in Covid-19

(2020) Francesco Rubino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020

(2020) Marie E. Killerby et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit

(2020) Geehan Suleyman et al.   JAMA Network Open

Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair

(2020) Frank M. Davis et al.   JCI Insight

Short-term consumption of a high-fat diet increases host susceptibility to Listeria monocytogenes infection

(2019) Vanessa Las Heras et al.   Microbiome

The obesity transition: stages of the global epidemic

(2019) Lindsay M Jaacks et al.   Lancet Diabetes & Endocrinology

Obesity worsens the outcome of influenza virus infection associated with impaired type I interferon induction in mice

(2019) Ho Namkoong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Body Habitus and Risk of Mortality in Pediatric Sepsis and Septic Shock: A Retrospective Cohort Study

(2019) Patrick A. Ross et al.   JOURNAL OF PEDIATRICS

Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution

(2019) Rebekah Honce et al.   Frontiers in Immunology

Metabolically healthy obesity: facts and fantasies

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

(2019) Lavanya Vishvanath et al.   JOURNAL OF CLINICAL INVESTIGATION

Perturbation of the Monocyte Compartment in Human Obesity

(2019) Kathleen Friedrich et al.   Frontiers in Immunology

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems

(2018) Shihab Kochumon et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Risk of Infection in Type 1 and Type 2 Diabetes Compared With the General Population: A Matched Cohort Study

(2018) Iain M. Carey et al.   DIABETES CARE

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

(2018) Lily Boutens et al.   DIABETOLOGIA

Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts

(2018) Lorena Tuchscherr et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+adipose tissue macrophage production in obese mice

(2018) Cameron Griffin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders

(2018) Marialetizia Rastelli et al.   Obesity

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

(2018) Ailing Liu et al.   Nature Communications

Overweight or obese BMI is associated with earlier, but not later survival after common acute illnesses

(2018) Hallie C. Prescott et al.   BMC Geriatrics

Outcomes and Resource Use Among Overweight and Obese Children With Sepsis in the Pediatric Intensive Care Unit

(2018) Laura S. Peterson et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Sex differences in obesity, lipid metabolism, and inflammation—A role for the sex chromosomes?

(2018) Temeka Zore et al.   Molecular Metabolism

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

(2018) Angli Xue et al.   Nature Communications

Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses

(2018) Joe-Ann S. Moser et al.   Influenza and Other Respiratory Viruses

Cytokine, chemokine and cytokine receptor changes are associated with metabolic improvements after bariatric surgery

(2018) Risa M Wolf et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice

(2018) Lynn M. Frydrych et al.   JOURNAL OF IMMUNOLOGY

Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction

(2017) Kristien E. Bouter et al.   GASTROENTEROLOGY

Increased risk of influenza among vaccinated adults who are obese

(2017) S D Neidich et al.   INTERNATIONAL JOURNAL OF OBESITY

The initiation of metabolic inflammation in childhood obesity

(2017) Kanakadurga Singer et al.   JOURNAL OF CLINICAL INVESTIGATION

The impact of obesity and timely antiviral administration on severe influenza outcomes among hospitalized adults

(2017) Hannah E. Segaloff et al.   JOURNAL OF MEDICAL VIROLOGY

The role of increased body mass index in outcomes of sepsis: a systematic review and meta-analysis

(2017) Sicong Wang et al.   BMC Anesthesiology

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

Prostaglandin E2 As a Modulator of Viral Infections

(2017) Willem J. Sander et al.   Frontiers in Physiology

The Intestinal Immune System in Obesity and Insulin Resistance

(2016) Daniel A. Winer et al.   Cell Metabolism

Obesity Exacerbates Sepsis-Induced Oxidative Damage in Organs

(2016) Fabricia Petronilho et al.   INFLAMMATION

Impaired Recognition ofMycobacterium tuberculosisby Alveolar Macrophages From Diabetic Mice

(2016) Nuria Martinez et al.   JOURNAL OF INFECTIOUS DISEASES

Metabolic Syndrome and Risk of Cervical Human Papillomavirus Incident and Persistent Infection

(2016) Xin Huang et al.   MEDICINE

Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice

(2016) Nuria Martinez et al.   MICROBES AND INFECTION

The Role of Obesity in Sepsis Outcome among Critically Ill Patients: A Retrospective Cohort Analysis

(2016) Matthaios Papadimitriou-Olivgeris et al.   Biomed Research International

Influence of Obesity Diagnosis With Organ Dysfunction, Mortality, and Resource Use Among Children Hospitalized With Infection in the United States

(2016) Nidhi Maley et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Increased airway glucose increases airway bacterial load in hyperglycaemia

(2016) Simren K. Gill et al.   Scientific Reports

Endotoxins are associated with visceral fat mass in type 1 diabetes

(2016) Mariann I. Lassenius et al.   Scientific Reports

Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity

(2015) Kanakadurga Singer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of obesity on sepsis mortality: A systematic review

(2015) Vrinda Trivedi et al.   JOURNAL OF CRITICAL CARE

Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice

(2015) J. Justin Milner et al.   JOURNAL OF IMMUNOLOGY

CREB pathway links PGE2 signaling with macrophage polarization

(2015) Bing Luan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Obesity and 1-Year Outcomes in Older Americans With Severe Sepsis*

(2014) Hallie C. Prescott et al.   CRITICAL CARE MEDICINE

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

(2014) Kanakadurga Singer et al.   Molecular Metabolism

Effect of Lipopolysaccharide on Inflammation and Insulin Action in Human Muscle

(2013) Hanyu Liang et al.   PLoS One

Sex Differences in the Response to Viral Infections: TLR8 and TLR9 Ligand Stimulation Induce Higher IL10 Production in Males

(2012) Maria Gabriella Torcia et al.   PLoS One

Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue

(2012) Ulrika S. Pettersson et al.   PLoS One

Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus

(2011) Judith D. Easterbrook et al.   Influenza and Other Respiratory Viruses

Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications

(2011) Hideo Nakarai et al.   Innate Immunity

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways

(2011) Alejandro A. Pezzulo et al.   PLoS One

Diabetic Mice Display a Delayed Adaptive Immune Response to Mycobacterium tuberculosis

(2010) T. Vallerskog et al.   JOURNAL OF IMMUNOLOGY

Morbid Obesity as a Risk Factor for Hospitalization and Death Due to 2009 Pandemic Influenza A(H1N1) Disease

(2010) Oliver W. Morgan et al.   PLoS One

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

(2009) Jin-Kui Yang et al.   ACTA DIABETOLOGICA

Mice Chronically Fed High-Fat Diet Have Increased Mortality and Disturbed Immune Response in Sepsis

(2009) Louise Strandberg et al.   PLoS One

Mechanisms of macrophage activation in obesity-induced insulin resistance

(2008) Justin I Odegaard et al.   Nature clinical practice. Endocrinology & metabolism