G‐Quadruplexes act as sequence‐dependent protein chaperones

Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes

(2020) Sreejana Ray et al.   ACS Chemical Biology

Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates

(2020) Johan Aarum et al.   EMBO REPORTS

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

(2019) Jacob R. Mann et al.   NEURON

Assembly of Proteins by Free RNA during the Early Phase of Proteostasis Stress

(2019) Marion Alriquet et al.   JOURNAL OF PROTEOME RESEARCH

The nucleolus functions as a phase-separated protein quality control compartment

(2019) F. Frottin et al.   SCIENCE

RNA structure drives interaction with proteins

(2019) Natalia Sanchez de Groot et al.   Nature Communications

DNA Facilitates Oligomerization and Prevents Aggregation via DNA Networks

(2019) Theodore J. Litberg et al.   BIOPHYSICAL JOURNAL

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Fluorescence-based tools to probe G-quadruplexes in cell-free and cellular environments

(2018) Sudeshna Manna et al.   RSC Advances

Quantitative Evaluation of Toxic Polyglycine Biosynthesis and Aggregation in Cell Models Expressing Expanded CGG Repeats

(2018) Magdalena Derbis et al.   Frontiers in Genetics

C9orf72-mediated ALS and FTD: multiple pathways to disease

(2018) Rubika Balendra et al.   Nature Reviews Neurology

Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop

(2018) Elena Butovskaya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter

(2018) Anjali Sengar et al.   NUCLEIC ACIDS RESEARCH

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

(2017) Tariq Afroz et al.   Nature Communications

Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress

(2016) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noninvasive monitoring of environmental toxicity through green fluorescent protein expressing Escherichia coli

(2016) Young Hoon Song et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING

Visualizing chaperone-assisted protein folding

(2016) Scott Horowitz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Do nucleic acids moonlight as molecular chaperones?

(2016) Brianne E. Docter et al.   NUCLEIC ACIDS RESEARCH

Visualizing chaperone-assisted protein folding

(2016) Scott Horowitz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

(2016) Erin G Conlon et al.   eLife

A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis

(2015) Martin Haslbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

Fragile X mental retardation protein interactions with a G quadruplex structure in the 3′-untranslated region of NR2B mRNA

(2015) Snezana Stefanovic et al.   Molecular BioSystems

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

(2015) Nikita Vasilyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

M1 RNA is important for the in-cell solubility of its cognate C5 protein: Implications for RNA-mediated protein folding

(2015) Ahyun Son et al.   RNA Biology

FMRP interacts with G-quadruplex structures in the 3’-UTR of its dendritic target Shank1 mRNA

(2015) Yang Zhang et al.   RNA Biology

N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes

(2014) Navin C. Sabharwal et al.   FEBS Journal

Polyphosphate Is a Primordial Chaperone

(2014) Michael J. Gray et al.   MOLECULAR CELL

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules

(2014) Ouissame Bounedjah et al.   NUCLEIC ACIDS RESEARCH

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Extended Stokes Shift in Fluorescent Proteins: Chromophore–Protein Interactions in a Near-Infrared TagRFP675 Variant

(2013) Kiryl D. Piatkevich et al.   Scientific Reports

On the aggregation properties of FMRP - a link with the FXTAS syndrome?

(2011) Ljiljana Sjekloća et al.   FEBS Journal

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Autism spectrum disorder in fragile X syndrome: A longitudinal evaluation

(2009) R. Nick Hernandez et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Green fluorescent protein: structure, folding and chromophore maturation

(2009) Timothy D. Craggs   CHEMICAL SOCIETY REVIEWS

Arrangements of human telomere DNA quadruplex in physiologically relevant K + solutions

(2009) D. Renčiuk et al.   NUCLEIC ACIDS RESEARCH

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding

(2008) J. Winter et al.   CELL

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

(2008) Gary J. Bassell et al.   NEURON