γ‐Secretase cleavage of the Alzheimer risk factor TREM 2 is determined by its intrinsic structural dynamics

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage

(2019) Alexander Götz et al.   BIOPHYSICAL JOURNAL

Structure and Function of the γ-Secretase Complex

(2019) Michael S. Wolfe   BIOCHEMISTRY

Beyond detergent micelles: The advantages and applications of non-micellar and lipid-based membrane mimetics for solution-state NMR

(2019) Kai Klöpfer et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

(2018) Mia C. Brown et al.   BIOPHYSICAL JOURNAL

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural basis of Notch recognition by human γ-secretase

(2018) Guanghui Yang et al.   NATURE

Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR

(2017) Franz Hagn et al.   Nature Protocols

Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains

(2017) Catherine L. Deatherage et al.   Science Advances

Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ

(2016) Marty A. Fernandez et al.   BIOCHEMISTRY

Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

(2016) Akio Fukumori et al.   EMBO JOURNAL

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

(2016) Teng Jiang et al.   NEUROBIOLOGY OF AGING

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

(2015) Li Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases

(2015) Daniel Fleck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

(2015) David M. Bolduc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of microglial survival and proliferation in health and diseases

(2015) Tyler K. Ulland et al.   SEMINARS IN IMMUNOLOGY

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Side-Chain to Main-Chain Hydrogen Bonding Controls the Intrinsic Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix

(2014) Christina Scharnagl et al.   BIOPHYSICAL JOURNAL

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

A fast growing spectrum of biological functions of γ-secretase in development and disease

(2013) Nathalie Jurisch-Yaksi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above-Average Backbone Dynamics

(2013) Oxana Pester et al.   CHEMBIOCHEM

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimized Phospholipid Bilayer Nanodiscs Facilitate High-Resolution Structure Determination of Membrane Proteins

(2013) Franz Hagn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap scheduling

(2012) Sven G. Hyberts et al.   JOURNAL OF BIOMOLECULAR NMR

The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase

(2012) Oxana Pester et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

relaxGUI: a new software for fast and simple NMR relaxation data analysis and calculation of ps-ns and μs motion of proteins

(2011) Michael Bieri et al.   JOURNAL OF BIOMOLECULAR NMR

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites

(2010) Praveen K. Madala et al.   CHEMICAL REVIEWS

Poisson-Gap Sampling and Forward Maximum Entropy Reconstruction for Enhancing the Resolution and Sensitivity of Protein NMR Data

(2010) Sven G. Hyberts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structural basis for intramembrane assembly of an activating immunoreceptor complex

(2010) Matthew E Call et al.   NATURE IMMUNOLOGY

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY