Twenty years of research on HPV vaccines based on genetically modified lactic acid bacteria: an overview on the gut-vagina axis

Multiple HPV 16 infection with two strains: a possible marker of neoplastic progression

(2020) Maria Teresa Bruno et al.   BMC CANCER

Lactic Acid Bacteria as a Live Delivery System for the in situ Production of Nanobodies in the Human Gastrointestinal Tract

(2019) Beatriz del Rio et al.   Frontiers in Microbiology

Extracellular overproduction of E7 oncoprotein of Iranian human papillomavirus type 16 by genetically engineered Lactococcus lactis

(2019) Amir Hossein Mohseni et al.   BMC BIOTECHNOLOGY

Oral Administration of Poly-Gamma-Glutamic Acid Significantly Enhances the Antitumor Effect of HPV16 E7-Expressing Lactobacillus casei in a TC-1 Mouse Model

(2019) Eunjin Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The first clinical use of a recombinant Lactococcus lactis expressing human papillomavirus type 16 E7 oncogene oral vaccine: A phase I safety and immunogenicity trial in healthy women volunteers

(2019) Amir Hossein Mohseni et al.   MOLECULAR CANCER THERAPEUTICS

Phase 1 Safety and Immunogenicity Trial of Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E6 Oncoprotein Vaccine

(2019) Sedigheh Taghinezhad-S et al.   Molecular Therapy-Methods & Clinical Development

Optimization of human papillomavirus (HPV) type 16 E7-expressing lactobacillus-based vaccine for induction of mucosal E7-specific IFNγ-producing cells

(2018) Atsushi Komatsu et al.   VACCINE

Oral immunization with recombinant Lactococcus lactis NZ9000 expressing human papillomavirus type 16 E7 antigen and evaluation of its immune effects in female C57BL/6 mice

(2018) Amir Hossein Mohseni et al.   JOURNAL OF MEDICAL VIROLOGY

Extracellular overproduction of recombinant Iranian HPV-16 E6 oncoprotein in Lactococcus lactis using the NICE system

(2018) Sedigheh Taghinezhad-S et al.   Future Virology

Protection against human papillomavirus type 16-induced tumors in C57BL/6 mice by mucosal vaccination with Lactococcus lactis NZ9000 expressing E6 oncoprotein

(2018) Sedigheh Taghinezhad-S et al.   MICROBIAL PATHOGENESIS

Codon optimization of Iranian human papillomavirus Type 16 E6 oncogene for Lactococcus lactis subsp. cremoris MG1363

(2017) Sedigheh Taghinezhad-S et al.   Future Virology

Efficient production and optimization of E7 oncoprotein from Iranian human papillomavirus type 16 in Lactococcus lactis using nisin-controlled gene expression (NICE) system

(2017) Amir Hossein Mohseni et al.   MICROBIAL PATHOGENESIS

Expanded strain coverage for a highly successful public health tool: Prophylactic 9-valent human papillomavirus vaccine

(2017) Zhigang Zhang et al.   Human Vaccines & Immunotherapeutics

A plant protein signal sequence improved humoral immune response to HPV prophylactic and therapeutic DNA vaccines

(2017) Silvia Massa et al.   Human Vaccines & Immunotherapeutics

Use of Wild Type or Recombinant Lactic Acid Bacteria as an Alternative Treatment for Gastrointestinal Inflammatory Diseases: A Focus on Inflammatory Bowel Diseases and Mucositis

(2017) Rodrigo D. De Oliveira Carvalho et al.   Frontiers in Microbiology

Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study

(2017) Amir Hossein Mohseni et al.   Probiotics and Antimicrobial Proteins

Chimeric L2-Based Virus-Like Particle (VLP) Vaccines Targeting Cutaneous Human Papillomaviruses (HPV)

(2017) Bettina Huber et al.   PLoS One

Lactic acid bacteria as mucosal delivery vehicles: a realistic therapeutic option

(2016) Miao Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Targeting immune response with therapeutic vaccines in premalignant lesions and cervical cancer: hope or reality from clinical studies

(2016) P Vici et al.   Expert Review of Vaccines

Oral Immunization with a RecombinantLactococcus lactis–Expressing HIV-1 Antigen on Group AStreptococcusPilus Induces Strong Mucosal Immunity in the Gut

(2015) Venkateswarlu Chamcha et al.   JOURNAL OF IMMUNOLOGY

Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients

(2014) Kei Kawana et al.   VACCINE

Enhancement of Ad-CRT/E7-Mediated Antitumor Effect by Preimmunization with L. lactis Expressing HPV-16 E7

(2014) Blanca R. Rangel-Colmenero et al.   VIRAL IMMUNOLOGY

Mucosal vaccines

(2014) Mevyn Nizard et al.   Human Vaccines & Immunotherapeutics

Intranasal immunization with recombinant Lactococci carrying human papillomavirus E7 protein and mouse interleukin-12 DNA induces E7-specific antitumor effects in C57BL/6 mice

(2013) YIJIE LI et al.   Oncology Letters

Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface

(2012) Pedro Ribelles et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antiviral activity of Bifidobacterium adolescentisSPM1005-A on human papillomavirus type 16

(2012) Min-Kyeong Cha et al.   BMC Medicine

Lactic acid bacteria: a promising alternative for recombinant protein production

(2012) Elena García-Fruitós   Microbial Cell Factories

Immunization against Leishmania major Infection Using LACK- and IL-12-Expressing Lactococcus lactis Induces Delay in Footpad Swelling

(2012) Felix Hugentobler et al.   PLoS One

Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner

(2012) Ayumi Taguchi et al.   VACCINE

Oral administration of HPV-16 L2 displayed on Lactobacillus casei induces systematic and mucosal cross-neutralizing effects in Balb/c mice

(2012) Sun-Woo Yoon et al.   VACCINE

Evaluation of Oral Immunization with Recombinant Avian Influenza Virus HA1 Displayed on the Lactococcus lactis Surface and Combined with the Mucosal Adjuvant Cholera Toxin Subunit B

(2011) Han Lei et al.   Clinical and Vaccine Immunology

Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines

(2011) Luis G Bermúdez-Humarán et al.   Microbial Cell Factories

Lactococcus lactis-based vaccines from laboratory bench to human use: An overview

(2011) Mohammed Bahey-El-Din   VACCINE

A review of prophylactic human papillomavirus vaccines: Recommendations and monitoring in the US

(2010) Eileen F. Dunne et al.   CANCER

Human papillomavirus type 16 E6-specific antitumor immunity is induced by oral administration of HPV16 E6-expressing Lactobacillus casei in C57BL/6 mice

(2010) Tae-Young Lee et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunology of gut mucosal vaccines

(2010) Marcela F. Pasetti et al.   IMMUNOLOGICAL REVIEWS

Perspectives for Preventive and Therapeutic HPV Vaccines

(2010) Ken Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Efficient secretion of a modified E7 protein from human papilloma virus type-16 by Lactococcus lactis

(2010) D. Quistián-Martínez et al.   LETTERS IN APPLIED MICROBIOLOGY

Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7

(2010) Katsuyuki Adachi et al.   VACCINE

Human papilloma viruses and cancer in the post-vaccine era

(2009) E. Galani et al.   CLINICAL MICROBIOLOGY AND INFECTION

Role of β7 Integrins in Intestinal Lymphocyte Homing and Retention

(2009) G. Gorfu et al.   CURRENT MOLECULAR MEDICINE

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

(2009) Paulo Cesar Maciag et al.   VACCINE

Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease

(2008) B. del Rio et al.   Clinical and Vaccine Immunology

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

(2008) Jerry M. Wells et al.   NATURE REVIEWS MICROBIOLOGY

Innate inflammatory responses to the Gram-positive bacterium Lactococcus lactis

(2008) Karen K. Yam et al.   VACCINE