Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 10, Issue 8, Pages 2175-2187Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/hv.29269
Keywords
mucosal vaccines; cancer vaccines; mucosal adjuvants; resident memory T cells; homing molecules; immunization routes; mucosal imprinting
Categories
Funding
- Fondation ARC pour la recherche contre le cancer
- Agence Nationale de la Recherche (ANR)
- Site integre de recherche integre en cancerologie (SIRIC-Carpem)
- Institut National contre le Cancer (INCA)
- Labex d'immuno-oncologie
- Ligue contre le cancer
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Labex immuno-oncology
- Canceropole-region Ile-de-France
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The mucosal immune system displays several adaptations reflecting the exposure to the external environment. The efficient induction of mucosal immune responses also requires specific approaches, such as the use of appropriate administration routes and specific adjuvants and/or delivery systems. In contrast to vaccines delivered via parenteral routes, experimental, and clinical evidences demonstrated that mucosal vaccines can efficiently induce local immune responses to pathogens or tumors located at mucosal sites as well as systemic response. At least in part, such features can be explained by the compartmentalization of mucosal B and T cell populations that play important roles in the modulation of local immune responses. In the present review, we discuss molecular and cellular features of the mucosal immune system as well as novel immunization approaches that may lead to the development of innovative and efficient vaccines targeting pathogens and tumors at different mucosal sites.
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