Targeting immune response with therapeutic vaccines in premalignant lesions and cervical cancer: hope or reality from clinical studies

Definitive chemoradiation with full-dose gemcitabine for unresectable pancreatic cancer: A single-institution experience.

(2017) Jessica Zhou et al.   JOURNAL OF CLINICAL ONCOLOGY

Prevalence of KRAS, BRAF, NRAS, PIK3CA, and PTEN alterations in colorectal cancer: Analysis of a large international cohort of 5,900 patients.

(2017) Gargi Dan Basu et al.   JOURNAL OF CLINICAL ONCOLOGY

An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression

(2015) A E Rice et al.   CANCER GENE THERAPY

Immunotherapy: An Evolving Paradigm in the Treatment of Advanced Cervical Cancer

(2015) Ramez N. Eskander et al.   CLINICAL THERAPEUTICS

Therapeutic cancer vaccines

(2015) Cornelis J.M. Melief et al.   JOURNAL OF CLINICAL INVESTIGATION

Adoptive T-Cell Therapy Is a Promising Salvage Approach for Advanced or Recurrent Metastatic Cervical Cancer

(2015) Emese Zsiros et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic impact of postoperative morbidity after esophagectomy for esophageal cancer: Supplementary exploratory analysis of JCOG9907.

(2015) Hiroya Takeuchi et al.   JOURNAL OF CLINICAL ONCOLOGY

Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus–Targeted Tumor-Infiltrating T Cells

(2015) Sanja Stevanović et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+tumors when combined with an E6/E7 peptide vaccine

(2015) Todd Bartkowiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling pathways in HPV-associated cancers and therapeutic implications

(2015) Jiezhong Chen   REVIEWS IN MEDICAL VIROLOGY

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

A phase I dose-escalation clinical trial of a peptide-based human papillomavirus therapeutic vaccine withCandidaskin test reagent as a novel vaccine adjuvant for treating women with biopsy-proven cervical intraepithelial neoplasia 2/3

(2015) William W Greenfield et al.   OncoImmunology

DNA vaccine for cancer immunotherapy

(2015) Benjamin Yang et al.   Human Vaccines & Immunotherapeutics

Orchestrating immune check-point blockade for cancer immunotherapy in combinations

(2014) Jose Luis Perez-Gracia et al.   CURRENT OPINION IN IMMUNOLOGY

Immunologic treatments for precancerous lesions and uterine cervical cancer

(2014) Patrizia Vici et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer

(2014) Osama E Rahma et al.   Journal of Translational Medicine

Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

(2014) L. Maldonado et al.   Science Translational Medicine

Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets

(2014) Florian Wimmers et al.   Frontiers in Immunology

HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

(2013) Mariette I E van Poelgeest et al.   Journal of Translational Medicine

Immunotherapy of cancer in 2012

(2012) John M. Kirkwood et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Treatment of Established Lesions Caused by High-risk Human Papilloma Virus Using a Synthetic Vaccine

(2012) Cornelis J. M. Melief   JOURNAL OF IMMUNOTHERAPY

Regression of high-grade cervical intraepithelial neoplasia with TG4001 targeted immunotherapy

(2011) Jean-Luc Brun et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Therapeutic vaccination against human papilloma virus induced malignancies

(2011) Sjoerd H van der Burg et al.   CURRENT OPINION IN IMMUNOLOGY

Human Papillomaviruses As Therapeutic Targets in Human Cancer

(2011) Karin Hellner et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3

(2010) Margaret R.E. MCCREDIE et al.   AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Control of Cervicovaginal HPV-16 E7-Expressing Tumors by the Combination of Therapeutic HPV Vaccination and Vascular Disrupting Agents

(2010) Qi Zeng et al.   HUMAN GENE THERAPY

HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future

(2010) Luciano Mariani et al.   Journal of Translational Medicine

From Human Papillomavirus to Cervical Cancer

(2010) Mark Schiffman et al.   OBSTETRICS AND GYNECOLOGY

Currently approved prophylactic HPV vaccines

(2009) Diane M Harper   Expert Review of Vaccines

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

(2009) Paulo Cesar Maciag et al.   VACCINE

Development of an Adenoviral Vaccine Against E6 and E7 Oncoproteins to Prevent Growth of Human Papillomavirus–Positive Cancer

(2008) Dong Wook Lee et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

(2008) G. G. Kenter et al.   CLINICAL CANCER RESEARCH

A Phase I Trial of a Human Papillomavirus DNA Vaccine for HPV16+ Cervical Intraepithelial Neoplasia 2/3

(2008) C. L. Trimble et al.   CLINICAL CANCER RESEARCH

Antigen-specific immunotherapy of cervical and ovarian cancer

(2008) Chien-Fu Hung et al.   IMMUNOLOGICAL REVIEWS

Epidemiology and Natural History of Human Papillomavirus Infections and Type-Specific Implications in Cervical Neoplasia

(2008) F. Xavier Bosch et al.   VACCINE