Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome

Vitamin K in Chronic Kidney Disease

(2019) Mario Cozzolino et al.   Nutrients

Effect of vitamin K2 on type 2 diabetes mellitus: A review

(2018) Yan Li et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

(2018) Tao Gong et al.   TRENDS IN IMMUNOLOGY

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect

(2018) Donika Ivanova et al.   Redox Biology

Control of Inflammasome Activation by Phosphorylation

(2018) Tao Gong et al.   TRENDS IN BIOCHEMICAL SCIENCES

GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics

(2018) Tiantian Tang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammation in gout: mechanisms and therapeutic targets

(2017) Alexander K. So et al.   Nature Reviews Rheumatology

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

(2016) Leanne Mortimer et al.   NATURE IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease

(2014) Jan K. Nowak et al.   Scientific Reports

Vitamin K Deficiency Is Associated with Incident Knee Osteoarthritis

(2013) Devyani Misra et al.   AMERICAN JOURNAL OF MEDICINE

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

Menadione (Vitamin K3) Is a Catabolic Product of Oral Phylloquinone (Vitamin K1) in the Intestine and a Circulating Precursor of Tissue Menaquinone-4 (Vitamin K2) in Rats

(2013) Yoshihisa Hirota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-κB activation

(2010) S. Tanaka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation

(2010) Yusuke Ohsaki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vitamin K deficiency bleeding (VKDB) in early infancy

(2008) Martin J. Shearer   BLOOD REVIEWS

High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease

(2008) A. Kuwabara et al.   OSTEOPOROSIS INTERNATIONAL