The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease

Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase

(2020) Karolina Michalska et al.   PROTEIN SCIENCE

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis

(2019) Dereje Abate Negatu et al.   mBio

Mycobacterium tuberculosis infection of host cells in space and time

(2019) Claudio Bussi et al.   FEMS MICROBIOLOGY REVIEWS

Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

(2019) Harrisham Kaur et al.   Frontiers in Neuroscience

Arginine-deprivation–induced oxidative damage sterilizes Mycobacterium tuberculosis

(2018) Sangeeta Tiwari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bedaquiline and delamanid in the treatment of multidrug‐resistant tuberculosis: Promising but challenging

(2018) Yang Li et al.   DRUG DEVELOPMENT RESEARCH

Mechanism of Fluorinated Anthranilate-Induced Growth Inhibition in Mycobacterium tuberculosis

(2018) M. Nurul Islam et al.   ACS Infectious Diseases

Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol

(2017) Xiao-Kang Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

(2017) Dylan Dodd et al.   NATURE

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase

(2017) Samantha Wellington et al.   Nature Chemical Biology

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control ofMycobacterium tuberculosis

(2017) Uma S. Gautam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

(2017) Igor Cervenka et al.   SCIENCE

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

(2017) Katherine A. Abrahams et al.   Scientific Reports

The ins and outs of theMycobacterium tuberculosis-containing vacuole

(2016) David G. Russell   CELLULAR MICROBIOLOGY

Highl-Trp affinity of indoleamine 2,3-dioxygenase 1 is attributed to two residues located in the distal heme pocket

(2016) Hajime J. Yuasa   FEBS Journal

Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site

(2015) Tammie V. M. Cookson et al.   BIOCHEMISTRY

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

(2015) Anne Lenaerts et al.   IMMUNOLOGICAL REVIEWS

Essential roles of methionine andS-adenosylmethionine in the autarkic lifestyle ofMycobacterium tuberculosis

(2015) Michael Berney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

(2015) Ghader Bashiri et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase fromMycobacterium tuberculosis

(2014) Tammie V. M. Cookson et al.   BIOCHEMICAL JOURNAL

Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis inMycobacterium tuberculosis

(2014) Genevieve L. Evans et al.   CHEMBIOCHEM

The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition

(2013) Alina Castell et al.   BIOCHEMISTRY

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

Feast or famine: the host-pathogen battle over amino acids

(2013) Yanjia J. Zhang et al.   CELLULAR MICROBIOLOGY

Indoleamine 2,3-dioxygenase in the pathogenesis of tuberculous pleurisy

(2013) Y. Suzuki et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis

(2012) Gamma Chi et al.   BIOCHEMISTRY

Serum Indoleamine 2,3-Dioxygenase Activity Predicts Prognosis of Pulmonary Tuberculosis

(2012) Yuzo Suzuki et al.   Clinical and Vaccine Immunology

Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site

(2012) Alexandra Manos-Turvey et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase fromMycobacterium tuberculosisby active site metamorphosis

(2011) Anne V. Due et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)

(2010) Alexandra Manos-Turvey et al.   ChemMedChem

Indoleamine 2,3-Dioxygenase 1 Is a Lung-Specific Innate Immune Defense Mechanism That Inhibits Growth of Francisella tularensis Tryptophan Auxotrophs

(2010) K. Peng et al.   INFECTION AND IMMUNITY

Characterization of the putative tryptophan synthase β-subunit from Mycobacterium tuberculosis

(2009) Hongbo Shen et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis

(2009) Clarissa M. Czekster et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host

(2008) T ZELANTE et al.   MICROBES AND INFECTION