Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site

Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis

(2012) Gamma Chi et al.   BIOCHEMISTRY

Elucidation ofMycobacterium tuberculosisType II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy

(2012) Anh Thu Tran et al.   ChemMedChem

Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis

(2012) M. D. McMahon et al.   JOURNAL OF BACTERIOLOGY

Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis

(2012) C. A. Madigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

(2011) Nicholas P. West et al.   CHEMICAL COMMUNICATIONS

The TB Structural Genomics Consortium: A decade of progress

(2011) Nicholas Chim et al.   TUBERCULOSIS

Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)

(2010) Alexandra Manos-Turvey et al.   ChemMedChem

Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High-Throughput Screening

(2010) Mahalakshmi Vasan et al.   ChemMedChem

Targeting Multiple Chorismate-Utilizing Enzymes with a Single Inhibitor: Validation of a Three-Stage Design

(2010) Kristin T. Ziebart et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Escherichia coli Enterobactin-specific Isochorismate Synthase (EntC) Bound to its Reaction Product Isochorismate: Implications for the Enzyme Mechanism and Differential Activity of Chorismate-utilizing Enzymes

(2010) Sudharsan Sridharan et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues

(2010) Richard J. Payne et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes

(2009) Richard J. Payne et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Purification and characterization of anthranilate synthase component I (TrpE) from Mycobacterium tuberculosis H37Rv

(2008) Xiaohua Lin et al.   PROTEIN EXPRESSION AND PURIFICATION