Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells

Cellular sources of IL-6 and associations with clinical phenotypes and outcomes in PAH

(2020) Catherine E. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

(2019) Ly Tu et al.   CIRCULATION RESEARCH

BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

(2019) Christian Hiepen et al.   PLOS BIOLOGY

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension

(2018) Toshio Suzuki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

(2018) Yuichi Tamura et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family

(2018) Nina Rol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Blood Outgrowth and Proliferation of Endothelial Colony Forming Cells are Related to Markers of Disease Severity in Patients with Pulmonary Arterial Hypertension

(2018) Josien Smits et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

(2018) Gonzalo Sánchez-Duffhues et al.   JOURNAL OF PATHOLOGY

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2

(2017) Claudia-Gabriela Mitrofan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

(2017) Josephine Pickworth et al.   Pulmonary Circulation

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage

(2016) Robert Szulcek et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial-to-Mesenchymal Transition

(2016) Kurt R. Stenmark et al.   CIRCULATION

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target SlugCLINICAL PERSPECTIVE

(2016) Rachel K. Hopper et al.   CIRCULATION

BMP signaling in vascular biology and dysfunction

(2016) Amaya García de Vinuesa et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium

(2016) Sarah L. Appleby et al.   JOURNAL OF IMMUNOLOGY

Impact of selective anti-BMP9 treatment on tumor cells and tumor angiogenesis

(2016) Verena Brand et al.   Molecular Oncology

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Novel homozygous BMP9 nonsense mutation causes pulmonary arterial hypertension: a case report

(2016) Guoliang Wang et al.   BMC Pulmonary Medicine

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

(2015) Nazzareno Galiè et al.   EUROPEAN HEART JOURNAL

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Targeting BMP signalling in cardiovascular disease and anaemia

(2015) Nicholas W. Morrell et al.   Nature Reviews Cardiology

BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus

(2015) Sandrine Levet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

Inhibition of Overactive Transforming Growth Factor–β Signaling by Prostacyclin Analogs in Pulmonary Arterial Hypertension

(2013) Takeshi Ogo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Changing Demographics, Epidemiology, and Survival of Incident Pulmonary Arterial Hypertension

(2012) Yi Ling et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of endothelial-mesenchymal transition in development and pathological process

(2012) Feng Lin et al.   IUBMB LIFE

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension

(2009) N. Selimovic et al.   EUROPEAN RESPIRATORY JOURNAL

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH