Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors

Hydrogen Peroxide–Releasing Hydrogels for Enhanced Endothelial Cell Activities and Neovascularization

(2018) Yunki Lee et al.   ACS Applied Materials & Interfaces

Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis

(2018) Tatsuya Osaki et al.   BIOMATERIALS

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma

(2018) Woojin M. Han et al.   Science Advances

Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling

(2018) Mayank Verma et al.   Cell Stem Cell

Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

(2017) Samad Ahadian et al.   Advanced Healthcare Materials

HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert

(2017) Joseph T. Rodgers et al.   Cell Reports

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

(2017) Claire Latroche et al.   Stem Cell Reports

The Fountain of Youth: A tale of parabiosis, stem cells, and rejuvenation

(2017) Massimo Conese et al.   Open Medicine

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease

(2016) Albert E. Almada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting

(2016) Claire C. Maesner et al.   Skeletal Muscle

Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units

(2016) S. G. M. Uzel et al.   Science Advances

A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions

(2015) E. E. Zahavi et al.   JOURNAL OF CELL SCIENCE

The central role of muscle stem cells in regenerative failure with aging

(2015) Helen M Blau et al.   NATURE MEDICINE

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sarcopenia and mortality among a population-based sample of community-dwelling older adults

(2015) Justin C. Brown et al.   Journal of Cachexia Sarcopenia and Muscle

Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model

(2014) Indranil Sinha et al.   CELL AND TISSUE RESEARCH

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Stem cell aging: mechanisms, regulators and therapeutic opportunities

(2014) Juhyun Oh et al.   NATURE MEDICINE

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

(2014) Christian Elabd et al.   Nature Communications

Three-dimensional neuron–muscle constructs with neuromuscular junctions

(2013) Yuya Morimoto et al.   BIOMATERIALS

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

Pax7 is critical for the normal function of satellite cells in adult skeletal muscle

(2013) J. von Maltzahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ forming gelatin-based tissue adhesives and their phenolic content-driven properties

(2013) Yunki Lee et al.   Journal of Materials Chemistry B

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

(2012) Irina M. Conboy et al.   CELL CYCLE

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

The Stem Cell Niche in Regenerative Medicine

(2012) Amy J. Wagers   Cell Stem Cell

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system

(2011) Xiufang Guo et al.   BIOMATERIALS

An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration

(2011) C. Lepper et al.   DEVELOPMENT

Emerging models and paradigms for stem cell ageing

(2011) D. Leanne Jones et al.   NATURE CELL BIOLOGY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices

(2010) Kiana Aran et al.   LAB ON A CHIP

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

(2009) Youngmok C. Jang et al.   FASEB JOURNAL

Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles

(2008) Massimiliano Cerletti et al.   CELL