DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases?

Acute sources of mitochondrial NAD+ during respiratory chain dysfunction

(2020) Christos Chinopoulos   EXPERIMENTAL NEUROLOGY

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

(2019) Denise van Marion et al.   Drug Design Development and Therapy

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

(2019) Deli Zhang et al.   Nature Communications

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations

(2019) Suet Nee Chen et al.   CIRCULATION RESEARCH

Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissue

(2019) Denise M.S. van Marion et al.   HEART RHYTHM

NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival

(2019) Michael M. Murata et al.   MOLECULAR BIOLOGY OF THE CELL

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(2019) Marc-André Maheu-Cadotte et al.   AMERICAN JOURNAL OF NURSING

Peripartum cardiomyopathy: basic mechanisms and hope for new therapies

(2019) Melanie Ricke-Hoch et al.   CARDIOVASCULAR RESEARCH

Sex Differences in Atrial Fibrillation

(2018) Jason G. Andrade et al.   CANADIAN JOURNAL OF CARDIOLOGY

Microtubule cytoskeleton regulates Connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene

(2018) Coline Macquart et al.   HUMAN MOLECULAR GENETICS

Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation

(2018) Nicolas Vignier et al.   HUMAN MOLECULAR GENETICS

Amelioration of desmin network defects by αB-crystallin overexpression confers cardioprotection in a mouse model of dilated cardiomyopathy caused by LMNA gene mutation

(2018) Zoi Galata et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

(2017) Hugh Calkins et al.   EUROPACE

Proteostasis in cardiac health and disease

(2017) Robert H. Henning et al.   Nature Reviews Cardiology

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

(2017) Mark Robson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lamin A/C -Related Cardiac DiseaseCLINICAL PERSPECTIVE

(2017) Edgar T. Hoorntje et al.   Circulation-Cardiovascular Genetics

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

(2017) Nicolas Diguet et al.   CIRCULATION

A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus

(2017) Alice Barateau et al.   PLoS One

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

Olaparib does not cause clinically relevant QT/QTc interval prolongation in patients with advanced solid tumours: results from two phase I studies

(2016) Helen Swaisland et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Common variation in atrial fibrillation: navigating the path from genetic association to mechanism

(2016) Nathan R. Tucker et al.   CARDIOVASCULAR RESEARCH

The DNA damage-induced cell death response: a roadmap to kill cancer cells

(2016) Sonja Matt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers

(2016) Saurabh Kumar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Wytyczne ESC dotyczące leczenia migotania przedsionków w 2016 roku, opracowane we współpracy z EACTS

(2016) Paulus Kirchhof et al.   Kardiologia Polska

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies

(2016) James S. Ware et al.   NEW ENGLAND JOURNAL OF MEDICINE

Your Father and Grandfather’s Atrial Fibrillation: A Review of the Genetics of the Most Common Pathologic Cardiac Dysrhythmia

(2015) Joseph A Palatinus et al.   CURRENT GENOMICS

Epidemiology of Acquired Valvular Heart Disease

(2014) Bernard Iung et al.   CANADIAN JOURNAL OF CARDIOLOGY

Nucleosomes Suppress the Formation of Double-strand DNA Breaks during Attempted Base Excision Repair of Clustered Oxidative Damages

(2014) Wendy J. Cannan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathophysiology and epidemiology of peripartum cardiomyopathy

(2014) Denise Hilfiker-Kleiner et al.   Nature Reviews Cardiology

Epidemiology of atrial fibrillation: European perspective

(2014) Massimo Zoni-Berisso et al.   Clinical Epidemiology

Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation

(2013) Deli Zhang et al.   CIRCULATION

Poly(ADP-ribose): PARadigms and PARadoxes

(2013) Alexander Bürkle et al.   MOLECULAR ASPECTS OF MEDICINE

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Dilated cardiomyopathy: the complexity of a diverse genetic architecture

(2013) Ray E. Hershberger et al.   Nature Reviews Cardiology

Inherited Cardiomyopathies

(2011) Hugh Watkins et al.   NEW ENGLAND JOURNAL OF MEDICINE

The burden of atrial fibrillation in the Netherlands

(2011) H. E. Heemstra et al.   Netherlands Heart Journal

Desmin-related myopathy

(2010) KY van Spaendonck-Zwarts et al.   CLINICAL GENETICS

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the ADP-Ribosylation Sites in the PARP-1 Automodification Domain: Analysis and Implications

(2009) Zhihua Tao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative stress induces degradation of mitochondrial DNA

(2009) Inna Shokolenko et al.   NUCLEIC ACIDS RESEARCH

Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia

(2008) M. Sakabe et al.   CARDIOVASCULAR RESEARCH

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

(2007) Paul et al.   Frontiers in Bioscience-Landmark