Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

Corrigendum: Blood-Based DNA Methylation Biomarkers for Type 2 Diabetes: Potential for Clinical Applications

(2019) Tarryn Willmer et al.   Frontiers in Endocrinology

Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury

(2019) Wei Liu et al.   CHINESE MEDICAL JOURNAL

Enforced lysosomal biogenesis rescues erythromycin- and clindamycin-induced mitochondria-mediated cell death in human cells

(2019) Paresh Prajapati et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A

(2019) Ying Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Autophagy in Kidney Disease

(2019) Mary E. Choi   Annual Review of Physiology

Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury

(2019) Jian-xing Liu et al.   LIFE SCIENCES

Taurine is an amino acid with the ability to activate autophagy in adipocytes

(2018) Hiroki Kaneko et al.   AMINO ACIDS

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model

(2018) Yutaro Otsuka et al.   Cell Communication and Signaling

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

(2018) Juha M. T. Hyttinen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

(2018) Xingchen Zhao et al.   JOURNAL OF PATHOLOGY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury

(2018) Jack L. Martin et al.   PEDIATRIC NEPHROLOGY

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease

(2018) Angela S. Brijmohan et al.   Frontiers in Pharmacology

Acute Kidney Injury

(2018) Ashley Farrar   NURSING CLINICS OF NORTH AMERICA

P53 in kidney injury and repair: Mechanism and therapeutic potentials

(2018) Chengyuan Tang et al.   PHARMACOLOGY & THERAPEUTICS

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets

(2017) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A

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Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features

(2017) Kentaro Inamura   Cancers

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway

(2016) Valentina Bouché et al.   Autophagy

Modeling Alveolar Soft Part Sarcoma Unveils Novel Mechanisms of Metastasis

(2016) Miwa Tanaka et al.   CANCER RESEARCH

The awesome lysosome

(2016) A. Ballabio   EMBO Molecular Medicine

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

(2016) Laura R. Rega et al.   KIDNEY INTERNATIONAL

Turn up the lysosome

(2016) Paul Saftig et al.   NATURE CELL BIOLOGY

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

Cystinosis: a review

(2016) Mohamed A. Elmonem et al.   Orphanet Journal of Rare Diseases

Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury

(2016) Aleksandra Kezic et al.   Oxidative Medicine and Cellular Longevity

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis

(2015) G. Napolitano et al.   EMBO Molecular Medicine

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy

(2015) Wei Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling

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International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology

(2015) Ravindra L Mehta et al.   LANCET

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Increased glucocerebrosidase expression and activity in preeclamptic placenta

(2015) J.M. Jebbink et al.   PLACENTA

Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein

(2015) Kiri Kilpatrick et al.   PLoS One

Pathophysiology of ischaemic acute kidney injury

(2015) Nigel Suren Kanagasundaram   ANNALS OF CLINICAL BIOCHEMISTRY

Endo-Lysosomal Dysfunction in Human Proximal Tubular Epithelial Cells Deficient for Lysosomal Cystine Transporter Cystinosin

(2015) Ekaterina A. Ivanova et al.   PLoS One

Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury

(2014) C. Quoilin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis

(2014) José A. Martina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Abnormal mitochondrial fusion–fission balance contributes to the progression of experimental sepsis

(2014) A. S. Gonzalez et al.   FREE RADICAL RESEARCH

The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

(2014) Marta Moskot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Intracellular Clusterin Attenuates Cell Death in Nephropathic Cystinosis

(2014) P. Sansanwal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The global implications of diabetes and cancer

(2014) Yuankai Shi et al.   LANCET

Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice

(2014) Tangli Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers

(2014) Eric C. Kauffman et al.   Nature Reviews Urology

Autophagy in Acute Kidney Injury and Repair

(2014) Liyu He et al.   NEPHRON CLINICAL PRACTICE

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function

(2013) Fitsum Guebre-Egziabher et al.   BIOCHIMIE

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The effect of renal hyperfiltration on urinary inflammatory cytokines/chemokines in patients with uncomplicated type 1 diabetes mellitus

(2013) R. Har et al.   DIABETOLOGIA

Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency

(2013) Nunzia Pastore et al.   EMBO Molecular Medicine

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

(2013) Carmine Spampanato et al.   EMBO Molecular Medicine

Dedifferentiation and aberrations of the endolysosomal compartment characterize the early stage of nephropathic cystinosis

(2013) C. Raggi et al.   HUMAN MOLECULAR GENETICS

GCN5-like Protein 1 (GCN5L1) Controls Mitochondrial Content through Coordinated Regulation of Mitochondrial Biogenesis and Mitophagy

(2013) Iain Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of the Rab27a-Dependent Trafficking and Secretory Mechanisms Improves Lysosomal Transport, Alleviates Endoplasmic Reticulum Stress, and Reduces Lysosome Overload in Cystinosis

(2013) J. L. Johnson et al.   MOLECULAR AND CELLULAR BIOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

(2013) Li Fang et al.   PLoS One

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Lipid Nephrotoxicity: New Concept for an Old Disease

(2012) Leonard Gyebi et al.   CURRENT HYPERTENSION REPORTS

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy in proximal tubules protects against acute kidney injury

(2012) Man Jiang et al.   KIDNEY INTERNATIONAL

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

(2011) Munehiro Kitada et al.   Experimental Diabetes Research

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

Sepsis and Acute Kidney Injury

(2011) A. Zarjou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apoptosis and acute kidney injury

(2011) Andrea Havasi et al.   KIDNEY INTERNATIONAL

Cysteamine therapy: a treatment for cystinosis, not a cure

(2011) Stephanie Cherqui   KIDNEY INTERNATIONAL

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Pathogenesis of diabetic nephropathy

(2011) Zemin Cao et al.   Journal of Diabetes Investigation

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

(2010) Man Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Abnormal mitochondrial autophagy in nephropathic cystinosis

(2010) Poonam Sansanwal et al.   Autophagy

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

The RAAS in the pathogenesis and treatment of diabetic nephropathy

(2010) Piero Ruggenenti et al.   Nature Reviews Nephrology

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes

(2009) Shigeyki Nada et al.   EMBO JOURNAL

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

The cell cycle and acute kidney injury

(2009) Peter M. Price et al.   KIDNEY INTERNATIONAL

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

(2009) Nigel A. Calcutt et al.   NATURE REVIEWS DRUG DISCOVERY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Participation of autophagy in renal ischemia/reperfusion injury

(2008) Chigure Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

(2008) Sudharsan Periyasamy-Thandavan et al.   KIDNEY INTERNATIONAL

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

Inflammation in Acute Kidney Injury

(2008) Gilbert R. Kinsey et al.   NEPHRON EXPERIMENTAL NEPHROLOGY