ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells

ROR1 associates unfavorable prognosis and promotes lymphoma growth in DLBCL by affecting PI3K/Akt/mTOR signaling pathway

(2019) Yuan Mao et al.   BIOFACTORS

Diffuse Large B cell Lymphoma: 2019 update on diagnosis, risk-stratification and treatment

(2019) Yang Liu et al.   AMERICAN JOURNAL OF HEMATOLOGY

Novel ROR1 Inhibitor ARI-1 Suppresses the Development of Non-Small Cell Lung Cancer

(2019) Xuesha Liu et al.   CANCER LETTERS

Prognostic value of receptor tyrosine kinase-like orphan receptor (ROR) family in cancer: A meta-analysis

(2019) Ramy R. Saleh et al.   CANCER TREATMENT REVIEWS

Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity

(2019) Norman Fultang et al.   PLoS One

Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia

(2018) Michael Y. Choi et al.   Cell Stem Cell

First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells

(2018) M. Hojjat-Farsangi et al.   LEUKEMIA

A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib

(2018) Amir Hossein Daneshmanesh et al.   PLoS One

Lnc-ing ROR1–HER3 and Hippo signalling in metastasis

(2017) Wei Zhuo et al.   NATURE CELL BIOLOGY

Lymphoma classification update: B-cell non-Hodgkin lymphomas

(2017) Manli Jiang et al.   Expert Review of Hematology

An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors

(2017) Satyen Harish Gohil et al.   OncoImmunology

Significance of stromal-1 and stromal-2 signatures and biologic prognostic model in diffuse large B-cell lymphoma

(2017) Asmaa Gaber Abdou et al.   Cancer Biology & Medicine

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

(2016) B. Cui et al.   BLOOD

Targeting ROR1 inhibits the self-renewal and invasive ability of glioblastoma stem cells

(2016) Eun-Hwa Jung et al.   CELL BIOCHEMISTRY AND FUNCTION

Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues

(2016) Ashwini Balakrishnan et al.   CLINICAL CANCER RESEARCH

Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia

(2015) P. Janovska et al.   CLINICAL CANCER RESEARCH

Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

(2015) Jian Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas

(2015) Xin Huang et al.   PLoS One

Small-Molecule Inhibitors of the Receptor Tyrosine Kinases: Promising Tools for Targeted Cancer Therapies

(2014) Mohammad Hojjat-Farsangi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy

(2014) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The receptor tyrosine kinase ROR1 – An oncofetal antigen for targeted cancer therapy

(2014) Mohammad Hojjat-Farsangi et al.   SEMINARS IN CANCER BIOLOGY

Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia

(2013) E. ten Hacken et al.   BLOOD

Targeting ROR1 Inhibits Epithelial-Mesenchymal Transition and Metastasis

(2013) B. Cui et al.   CANCER RESEARCH

The Tyrosine Kinase Receptor ROR1 Is Constitutively Phosphorylated in Chronic Lymphocytic Leukemia (CLL) Cells

(2013) Mohammad Hojjat-Farsangi et al.   PLoS One

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

(2012) Vincent T. Bicocca et al.   CANCER CELL

NKX2-1/TITF1/TTF-1-Induced ROR1 Is Required to Sustain EGFR Survival Signaling in Lung Adenocarcinoma

(2012) Tomoya Yamaguchi et al.   CANCER CELL

Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies

(2012) Amir Hossein Daneshmanesh et al.   LEUKEMIA & LYMPHOMA

ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor-Cell Growth

(2012) Suping Zhang et al.   PLoS One

Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells

(2010) Aniruddha Choudhury et al.   BRITISH JOURNAL OF HAEMATOLOGY

Differential expression of CKS-1B in typical and blastoid variants of mantle cell lymphoma

(2010) Nalan Akyurek et al.   HUMAN PATHOLOGY

Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy

(2008) Amir H. DaneshManesh et al.   INTERNATIONAL JOURNAL OF CANCER

Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A

(2008) Akira Nomachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

(2008) T. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA