A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib
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Title
A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib
Authors
Keywords
Apoptosis, Phosphorylation, Cytotoxicity, Pancreatic cancer, Carcinomas, Small molecules, Lung and intrathoracic tumors, Tyrosine kinases
Journal
PLoS One
Volume 13, Issue 6, Pages e0198038
Publisher
Public Library of Science (PLoS)
Online
2018-06-02
DOI
10.1371/journal.pone.0198038
References
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- (2013) M. Malvezzi et al. ANNALS OF ONCOLOGY
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- (2012) Tomoya Yamaguchi et al. CANCER CELL
- Enhancement of the Antiproliferative Activity of Gemcitabine by Modulation of c-Met Pathway in Pancreatic Cancer
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- (2010) Aniruddha Choudhury et al. BRITISH JOURNAL OF HAEMATOLOGY
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- (2009) D. L. Wheeler et al. ONCOLOGIST
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- (2008) Amir H. DaneshManesh et al. INTERNATIONAL JOURNAL OF CANCER
- Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
- (2008) T. Fukuda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ror receptor tyrosine kinases: orphans no more
- (2008) Jennifer L. Green et al. TRENDS IN CELL BIOLOGY
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