Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 232, Issue 11, Pages 2931-2937Publisher
WILEY
DOI: 10.1002/jcp.25798
Keywords
desmoplastic reaction; pancreatic cancer; pancreatic stellate cells; stroma
Categories
Funding
- Mashhad University of Medical Sciences
Ask authors/readers for more resources
Desmoplasia or abundant fibrotic stroma is a typical property of most malignancies, which has a great effect on tumorigenesis, angiogenesis, and resistance to therapy. The activated stroma cells comprises several cell types including endothelial cells, nerve cells, inflammatory/macrophages cells, stellate cells, and extracellular matrix. In other word, the interactions of cancer-stroma modulate tumorigenesis, therapy resistance, and poor delivery of drugs. Therefore, targeting the tumor stroma in combination with conventional chemotherapeutic agents could provide a promising approach in the treatment of pancreatic cancer. This review summarizes the current knowledge about pancreatic stellate cells, targeting stroma compartments with particular emphasis on preclinical, and clinical trials on targeting of stroma as an option in pancreatic cancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available